DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment capu and Fhdc1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001028473.2	Gene:	Fhdc1 / 229474	MGIID:	2684972	Length:	1149	Species:	Mus musculus

Alignment Length:	588	Identity:	149/588 - (25%)
Similarity:	227/588 - (38%)	Gaps:	138/588 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   774 SAKEDGEKPHAVAPPPPPPPPPLHAFVAPPPPPPPPPPPPPPLANYGAPPPPPPPPPGSGSAPPP 838
            |.||:|....|.|.......|.    .:||||||||||||.|.:..|..|.||         ||.
Mouse    11 SDKENGTLATAAAFMTGQTSPS----ASPPPPPPPPPPPPCPHSGEGFSPSPP---------PPL 62

  Fly   839 PPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWT 903
            |||.|  ||..|||||||             .||..:..|.:        |::...|.||..:|.
Mouse    63 PPPLP--GGPPIPPPPPP-------------GLPSVSYLNGY--------SSLGKKKRMRSFFWK 104

  Fly   904 RIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWT-EIEETPLDNID 967
            .|                          |:|.....            ..||| ..::.....||
Mouse   105 TI--------------------------PEEQVRGK------------TNIWTLAAKQQHQYQID 131

  Fly   968 EFT--ELFSRQA-IAPVSKPKELKVKRA------KSIKVLDPERSRNVGIIWRSLHVPSSEIEHA 1023
            :.|  |||.:|. .:..|.||......:      :.:.|||.:||.|:||..:........|...
Mouse   132 KKTIEELFGQQEDTSKASLPKRGGALNSSFRDAREEVTVLDAKRSMNIGIFLKQFKKSPQSIVED 196

  Fly  1024 IYHIDTSVVSLEALQHMSNIQATEDELQRIKEAAGGDI-PLDHPEQFLLDISLISMASERISCIV 1087
            ||...:.....|.|:.:..:....:|::::| |..||: .|...:.||..:..:...|.||..:|
Mouse   197 IYQGKSEHYGSETLREILKLLPESEEVKKLK-AFNGDVSKLSLADSFLHCLIQVPNYSLRIEAMV 260

  Fly  1088 FQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILG 1152
            .:.||..|.:.||:.:.|:...:::|:..|:|..:..::|..||.||.|. ..|.|.||.|..|.
Mouse   261 LKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGG-YAGNAVGFKLSSLL 324

  Fly  1153 KLKDVKSKESHTTLLHFIVRTYIAQRRKEGVHPLEIRLPIPEPADVERAAQMDFEEVQQQIFDLN 1217
            ||.|.|:.:....||||:.                      :.|..:.|..::|.|..|.:.:.:
Mouse   325 KLADTKANKPGMNLLHFVA----------------------QEAQKQDAILLNFSEKLQHVQETS 367

  Fly  1218 KKFLGCKRTTAKVLAASRPEIMEPFK------SKMEEFVEGADKSMAKLHQSLDECR-------D 1269
            :..|.........|......:.|..:      .:||:|::.|.:.:|:|.....|.:       |
Mouse   368 RLSLDITEAELHSLFVRTKSLQENIQLDQELCQQMEDFLQFAVEKLAELELWKRELQGEAHTLID 432

  Fly  1270 LFLETMRFYHFSPKACTLTLAQCTPDQFF-EYWTNFTNDFKDIWKKEITSLLNELMKKSKQAQIE 1333
            .|.|...         |:.|.:|.  |.| ::.|.|....||...:|    ..|..:..:|.::|
Mouse   433 FFCEDKE---------TMKLDECF--QIFRDFCTRFNKAVKDNHDRE----EQERKQLQRQKEME 482

  Fly  1334 SRR 1336
            .:|
Mouse   483 QKR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	102/451 (23%)
Fhdc1	NP_001028473.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..79		35/88 (40%)
		FH2	94..458	CDD:366959	98/436 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..540		5/26 (19%)
		PHA03307	524..>981	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	554..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..1149
		PHA03247	<823..1064	CDD:223021
		MTBD, microtubule-binding domain. /evidence=ECO:0000250\|UniProtKB:Q9C0D6	960..1086
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810