DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and daam-1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_503132.3	Gene:	daam-1 / 186392	WormBaseID:	WBGene00018976	Length:	987	Species:	Caenorhabditis elegans

Alignment Length:	774	Identity:	160/774 - (20%)
Similarity:	278/774 - (35%)	Gaps:	220/774 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 SLATIATASTASSDNQKT----------LQQILKKRLLNCTTLAEVHAVVNELLSSVDEPPRRPS 712
            |||...|:|..|..::.:          :.:.|..:|.:...|...|:::..|.....:....|.
Worm   326 SLAGSCTSSDISMSSETSSPIDFESVVGMAEALHIKLNHSQALPHFHSLLQHLFMVPSDDQHVPL 390

  Fly   713 KRCVNL--------------TEL-------LNASEATVYEYNKTGAEGCVKSFTDAETQTESEDC 756
            .|..:|              |::       ::.||......|....|...|   :.|...|..|.
Worm   391 WRLFDLILQHLTLQTTVNGMTDVNSPLQNHVDMSEILARLQNHCDYERIAK---ELEKAKEDMDL 452

  Fly   757 EGT-----------CKCGQSSTKVS-DNESAKEDGEKPHAVAPPPPPPPPPLHAFVAPPPPPPPP 809
            |.|           ...|::.:::| .:.||..        :|..|.|.|||    .||..||.|
Worm   453 ERTRIMELENRLADFSDGRAGSRISLASTSASS--------SPSDPCPSPPL----LPPVCPPAP 505

  Fly   810 PPPPPPLANYGAPPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPPPPPMSASPSKTTISPAPLPDP 874
            ||||||:                               ||:..||        |..:...|
Worm   506 PPPPPPI-------------------------------GGLTSPP--------KDALKNVP---- 527

  Fly   875 AEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPPAAN 939
                             .||..|:.|.|.|:               :.|.|..:
Worm   528 -----------------EPPGNMKTLNWQRL---------------TLDKTRGT----------- 549

  Fly   940 GADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSRQAIAPVSKPKEL--------KVKRAKSIK 996
                          :|..|::..:....:.|||....|.:...|.::.        :..:..:|.
Worm   550 --------------VWDGIDDEKIYKQLDLTELSGCFAASSSHKDEDTDTLYGTINRRPQQANIT 600

  Fly   997 VLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSV-VSLEALQHMSNIQATEDELQRIKEAA--- 1057
            |:||.|.:|..|:...|.:...||:.|:..:|... :..:.::.|.....|::||.:|.|:.
Worm   601 VIDPRRYQNCTIMLSKLKLSHKEIKQAMMSMDEKCKLPKDMIEQMLKFMPTKEELTQINESVQKH 665

  Fly  1058 GGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDLKLV 1122
            |....|...::::.:||.|....:|:.|:.....|.:.|..|...::.|.:.:....:::..:.:
Worm   666 GSPTVLALADRYMYEISSIPRFEQRLRCLNIIRSFHDRVEALVPFIQVVLKATSSCQQNKRFRQI 730

  Fly  1123 FSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSK-ESHTTLLHFIVRTYIAQRRKEGVHPL 1186
            .:|||.:|||:|.|.| .|.|.||.:..:.||.|||:. .:...||||:| .:|.::     :|
Worm   731 LTIILAIGNYLNFGKR-NGNAYGFEMASINKLADVKNALRNDRNLLHFLV-NFIEKK-----YP- 787

  Fly  1187 EIRLPIPEPADVERAAQMDFEEVQQQIFDLN------KKFLGCKRTTAKVLAASRPEIMEP---- 1241
            ::.....:.|.|..||:....|...:|.:|.      :|.|....:|.||   ..||.:.|
Worm   788 DLTKFKKDFATVTEAARFSQSETAAEIRNLEEALLIVRKELNLLESTTKV---ELPEHIPPENDR 849

  Fly  1242 FKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTN 1306
            |....:.|:|.|......|.:...|.::.|.:..:::.:||..     ....|::||.....|.|
Worm   850 FALVAKAFIEKATAEYHNLDKMFREMKNKFSDCAKYFCYSPSG-----GVPVPEEFFSVINKFLN 909

  Fly  1307 DFKD----IWKKEITSLLNELMKKSKQAQIESRRNVSTKVEKSGRISLKERMLMRRSKN 1361
            .|.:    :|                 |::|....:  |.:...|..|.::...||.:|
Worm   910 TFNEYHQQLW-----------------AEVEEEEKI--KRQTIARSFLAKKSTTRRKEN 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	100/453 (22%)
daam-1	NP_503132.3	Drf_GBD	39..212	CDD:368864
		Drf_FH3	216..408	CDD:368862	14/81 (17%)
		FH2	524..973	CDD:214697	109/522 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740