DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and cyk-1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_741211.3	Gene:	cyk-1 / 175983	WormBaseID:	WBGene00000872	Length:	1437	Species:	Caenorhabditis elegans

Alignment Length:	900	Identity:	205/900 - (22%)
Similarity:	346/900 - (38%)	Gaps:	229/900 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 SGDANQELFNTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWT------------------ 608
            |.|..|.::..|.:    |:...||.:.||::.:           ||
Worm   455 SRDPKQGMYVLLMI----NMMINGVDRNISDDQM-----------WTEETMWQARMRLRSEAAKD 504

  Fly   609 ----HTEQPTTS---------------------LPLTPGKLDKVAAWPFSSTPSGIRALESASLA 648
                :.|:.|||                     |....|||:.|..  ...|..|...|.:|:..
Worm   505 KLHKYIEKFTTSETVNSQIRDVAQNMLTEHNADLETLMGKLENVKG--EYDTLDGCFELLAANSE 567

  Fly   649 SLGAGGVAGSLATIATASTASSDNQKTLQQILKKR----LLNCTTL---AEVHAV----VNELLS 702
            :.|...|..|:..:.|.:......:::..::::..    ||:.|.:   |:...|    |.|::.
Worm   568 ATGTETVLLSILQLMTLTNEDMSTKRSYMKLIETAISDILLHRTPIDPQADYKFVFEVPVAEIID 632

  Fly   703 SVDEPPRRPSKRCVNLTELLNASEATVYEYNKT------GAEGCVKSFTDAETQTESEDCEGTCK 761
            .:.:  ...:|:....|.....:.|...||.||      .||...|...|.:...
Worm   633 KMQD--EEMAKKVRQATSAKQEAVAMQGEYWKTLCDFQKEAEELRKHINDPKIPL---------- 685

  Fly   762 CGQSSTKVSDNESAKEDGEKPHAVAPP----PPPPP--PPLHAFVAPPPPPPP---------PPP 811
              ...||:  |.||........:..||    |||||  ||:..  .|||||||         |||
Worm   686 --PPPTKM--NLSAPSTSAGGSSALPPITGGPPPPPGLPPITG--GPPPPPPPGGLPPITGGPPP 744

  Fly   812 PPPPLANYGAPP----PPPPPPPGSGSAPPPPPPAPIEGG--GGIPPPPPPMSASPSKTTISPAP 870
            ||||   .|.||    |||||||..|..||||||.|  ||  ||.||||||...:|    ::|.
Worm   745 PPPP---GGLPPISGGPPPPPPPPGGCPPPPPPPPP--GGFKGGPPPPPPPGMFAP----MAPV- 799

  Fly   871 LPDPAEGNWFHRTNTMRKSAVNPPK-------PMRPLYWTRIVTSAPPAPRPPSVANSTDSTENS 928
            :||                 ..|||       |||...|.....:....||
Worm   800 IPD-----------------YLPPKKVPKVDGPMRKFPWGAHTINPRDIPR-------------- 833

  Fly   929 GSSPDEPPAANGADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSRQAIAPVSKPKEL------ 987
                                   :..|....|..|.:...|..|.::.|..|.:....|
Worm   834 -----------------------ESFWVGTNEEQLTSDRMFDRLRTKFATKPAANSGTLGGVLNS 875

  Fly   988 --KVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATE--- 1047
              |||.|:.|.  |.:..:.:||:..|:.:..||::.||..::..|:::..|:.:.:....|
Worm   876 KKKVKTAQVIH--DDKLLQKLGILQGSIKMSHSELKLAILEVNEKVLTVGFLEQLRSAMPVEKEL 938

  Fly  1048 -DELQRIKEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQ 1111
             |:|:.:.:|...::|  ..|||:..:..|.....|:..::|:..|.|.:..|...:.:|.:..:
Worm   939 IDKLRAVNKAQFEEMP--EGEQFVTRLLQIQGLPLRLDLVLFKMRFSEVLNELKPAMSSVMEACE 1001

  Fly  1112 QLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIA 1176
            ::..||..:....::|..||:|.|..:....|..|::.:|.:|.|.|..::..||||.::
Worm  1002 EVRASEGFRTFLKLVLATGNFMGGATKNYSSAYAFDMRMLTRLVDTKDVDNRHTLLHHLI----- 1061

  Fly  1177 QRRKEGVHPLEIRLPIPEPADVERAAQMDFEEVQQ--QIFDLN-KKFLGCKRTTAKVLAASRPEI 1238
             ...:.:.|...|..:.:......:::::.:|:::  |:.:.| ||...|.:...  :...|
Worm  1062 -EEMKRIDPRRARFALTDFHHCIESSRVNADEIRKTVQLTENNIKKLENCLKVYK--IQGER--- 1120

  Fly  1239 MEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTN 1303
             :.|..||..|.|.|.|..:.:.....:.::.:...:::|.|:.|...:       ::||.....
Worm  1121 -DLFDEKMRPFHEKAVKEFSTVSSMCGKMKNDWESLVKYYAFNDKKYPM-------EEFFADIRT 1177

  Fly  1304 FTNDFKDIWKKEITSLLNELMKKSKQAQIESRRNVSTKVEKSGRISLKERMLMRR 1358
            |:..:.:.||:    |..|...|.|:|:.|:::....:..:..|..|:||..:.|
Worm  1178 FSEQYSNAWKE----LDAEAEAKRKEAEFETQKRKQLQQSQQERKPLQERQAINR 1228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	88/448 (20%)
cyk-1	NP_741211.3	Drf_GBD	201..387	CDD:283920
		Drf_FH3	422..630	CDD:283917	34/191 (18%)
		FH2	807..1257	CDD:214697	96/485 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164541
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840