DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and Grid2ip

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_001152793.1	Gene:	Grid2ip / 170935	MGIID:	2176213	Length:	1203	Species:	Mus musculus

Alignment Length:	1313	Identity:	262/1313 - (19%)
Similarity:	434/1313 - (33%)	Gaps:	424/1313 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 HYPYDRRSLCTSCSSNDSLFTDPVDELIISKHYLNTAAKEHNNPKAKRDRPLSEISVTSVDTLSP 234
            |....|::...||..:|.|     .:.:.:|..:.||.|:.     ..::.:.|: |.::..:.|
Mouse   119 HRERRRKAQEFSCQVDDIL-----GDRLTAKEQVFTALKQF-----AAEQRVDEL-VWTLTLVLP 172

  Fly   235 NTAKA-VLE----------------------LQKRCRADKLACLSLTRVTYLSIANDLQEVEEPD 276
            :.|:. ||:                      |.|.|||.:.......|.:        :..|.|:
Mouse   173 SEAQGPVLDNLRIFIPKKHRARFDEVVSQGLLGKLCRARRAQGAQRLRRS--------RSEERPE 229

  Fly   277 RASILHDTDLLVAPNSPAESSPDEELMALQLGKKLAQVLG--SGAGSP----------------- 322
            |  :|..|....||..|.|..|          :|...:||  :|.|.|
Mouse   230 R--LLVSTRASAAPRRPDEPPP----------RKATSLLGGRTGPGGPRRTVRVYKGNKSFGFTL 282

  Fly   323 ----------LTPGT-MEPCAAGSGSPL--ANG-ELFNVSKAKKVELQNLSSRFTAAVTQTPPGV 373
                      :.||: .|..:..||..:  .|| ::.|.|..|.|.:...|......|.:
Mouse   283 RGHGPVWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVE----- 342

  Fly   374 TSSTPNESGVTGPAGPLGATTSSPSLE--TQSTVIISFK------SSQTPVQSQTNSAASENVED 430
                         .||:...:.|.||:  |:::.:.|.:      .|...||.:|.|...:::
Mouse   343 -------------EGPVPFASDSDSLDSPTRASALTSLQWVADILPSSIRVQGRTFSQQLDHL-- 392

  Fly   431 DTAPLPLPPPP-------------------------PGFGTPTTPLL------------SSNVLK 458
                  |.||.                         |...||...:|            .....:
Mouse   393 ------LTPPERYGVCRALERFFQHRNIDTLIVDVYPVLDTPAKQVLWQFLYQLLTYEEQELCQE 451

  Fly   459 KVASF------TVEKSSAGNNSSNPPNLCPTSDETTLL--ATPCSSSLTVATLP----------P 505
            |:|.|      |..:||......:.|...|.....:.|  ::.|..||....|.          |
Mouse   452 KIACFLGYTAMTEPESSLDLEPESTPEPTPEPQPRSSLRASSMCRRSLRSQGLETSLSCGPGDCP 516

  Fly   506 EIAVGAAAGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQMLIKWLISTMQSNPKSSSGDANQELF 570
            |:.:....|....|.|:....:..|:.:| |.|.:.|.::
Mouse   517 EMPLPLIPGERQAGDGTSLPETPNPKMMS-AVYAELESRL------------------------- 555

  Fly   571 NTLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTSLPLT--PGKLDKVAAWPFS 633
                     |..:.|.:..:|....    ||           |..||..|  |..|..| :||..
Mouse   556 ---------NSSFKGKIGTMSKSRA----SP-----------PVPSLVGTSGPRTLSGV-SWPSD 595

  Fly   634 STPSGIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLLNCTTLAEVHAVVN 698
                  |.|.|.....|.:||:         ||.:||::.........:.......|..:||
Mouse   596 ------RLLPSPCYDPLCSGGL---------ASPSSSESHPYASLDSSRAPSPQPGLGSIHA--- 642

  Fly   699 ELLSSVDEPP-----RRPSKRCV-----------------NLTELLNASEATV-------YEYNK 734
                  |.||     |.||:|.:                 .|:|.|....:.|       .:|.:
Mouse   643 ------DSPPSPDPIRPPSRRKLFAFSRPVRSRDTDRFLDALSEQLGPRLSIVDDFLTPENDYEE 701

  Fly   735 TGAEGCVKSFTDAETQTESEDCEGTCKCGQSST--KVSDNESAKEDGEKPHAVAPPP--PPPPPP 795
            ........||...|..:.|| |..:.:.|.|.|  .:||:            :.|||  ||||||
Mouse   702 MSFHDDQGSFVTNERSSASE-CVSSSEEGSSLTYSSISDH------------IPPPPLSPPPPPP 753

  Fly   796 LHAFVAPPP-------PPPPPPPPPPPLANYGAPPPPPPPPPGSGSAPPPPPPAPIEGGGGIPPP 853
            | .|..|.|       |..||.....||.....|.|||||||    .|||.|.||
Mouse   754 L-PFHDPKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPP----LPPPVPCAP---------- 803

  Fly   854 PPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSV 918
                              |..:.|....|:.|...|       ::.|.|.::
Mouse   804 ------------------PMLSRGVGHRRSETSHMS-------VKRLRWEQV------------- 830

  Fly   919 ANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEI-EETPLDNIDEFTELF-------SR 975
                   |||..:                      ||.:: |::..|.:.:..:..       ::
Mouse   831 -------ENSEGT----------------------IWGQLGEDSDYDKLSDMVKYLDLELHFGTQ 866

  Fly   976 QAIAPVSKPKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHM 1040
            :...||..|:..:.|..  :::|..:::.|..|:...|.:...|:...:..::...:....|..:
Mouse   867 KPPKPVPGPEPFRKKEV--VEILSHKKAYNTSILLAHLKLTPGELRQVLMSMEPRRLEPAHLAQL 929

  Fly  1041 SNIQATEDELQR---IKEAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRK 1102
            .......||.||   .:||.|   .|..|:||:|.:..:.....|:..:.|||..:|....:...
Mouse   930 LLFAPDADEEQRYQAFREAPG---RLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGS 991

  Fly  1103 LETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLL 1167
            ||.:.|.|.:|..|..|..:...:|.:|||:|.|..:..:..||.::.|.:|...|:.:..:|.|
Mouse   992 LECLRQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFL 1056

  Fly  1168 HFIVRTYIAQRRKEGVHPLEIRLPIPEPADV-ERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVL 1231
            |.:.:: ::|...|.:...:....:|..|.| :||...|..::...:.::.   :.|:
Mouse  1057 HILAKS-LSQHFPELLGFAQDLPTVPLAAKVNQRALTGDLADLHDTVSEIQ---VACQ------- 1110

  Fly  1232 AASRPEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQ 1296
             :..|...:.|...|..|:|.|..::..|.....|..:...:.:.|:....||       .|.:.
Mouse  1111 -SMAPSSEDRFAVVMASFLETAQPALRALDGLQREAMEELGKALAFFGEDSKA-------TTSEA 1167

  Fly  1297 FFEYWTNFTNDFK 1309
            ||..::.|.:.|:
Mouse  1168 FFGIFSEFMSKFE 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	83/434 (19%)
Grid2ip	NP_001152793.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820	15/89 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..270		17/74 (23%)
		PDZ_signaling	269..342	CDD:238492	13/72 (18%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	13/86 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..541		14/74 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..586		8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..656		12/62 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..821		47/156 (30%)
		FH2	812..1180	CDD:280362	84/440 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810