DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and Fmn1

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	NP_034360.2	Gene:	Fmn1 / 14260	MGIID:	101815	Length:	1466	Species:	Mus musculus

Alignment Length:	1534	Identity:	392/1534 - (25%)
Similarity:	596/1534 - (38%)	Gaps:	449/1534 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RRGSRVRVLSRLMGQKRIR--------EAF-LHSPKLGSSSEVN---------LQGAGNGSSDWI 89
            ||..|.|.....:.|||.|        .|| :...::.|||.::         |:..||
Mouse   160 RRSGRRRESPEELRQKRTRRKGRGCQESAFQMGKDQVCSSSSLSFRARPNLRLLEERGN------ 218

  Fly    90 AAETEVEHGQLDCSAE-----PADFHDVVSLDCTDSLEYHN---CSSD---ECCYASNDTLTERQ 143
                .|..|.|..|..     ||:.......|    |.:.|   .|.|   |...:.:.:.||..
Mouse   219 ----LVPRGTLTSSLRRRESCPANILRTPDAD----LAFGNSGRTSEDTDLEGPLSPDSSPTEVG 275

  Fly   144 NRELQQRQRQHHHHHHHIHNAHESH-HHYPYDR--------RSLCTSCSSND--------SLFTD 191
            :.::..:.:..|.......|..||| .|...:|        :||..:||...        ...:.
Mouse   276 DADVGGQLKSSHQQEPPQPNVSESHGKHAGAERWSSRTRKSKSLERTCSKKPVSKVVAKIQEPSA 340

  Fly   192 PVDELIISKH---------------------YLNTAAKE---HNNPKAKRDRPLSEISVTSVDTL 232
            ||..::.:.|                     :|.....|   |::.:.:.::|    .:.|:.:.
Mouse   341 PVKRIVRAHHDGKGRVAYGPETQTEFIPKADFLTLPGGETETHSSGRLEEEQP----GIKSLRSS 401

  Fly   233 SPNTAKAVLE-----------LQKRCRADKL--------ACLSL-TRVTYLSIANDLQEVEEPDR 277
            :|..|....|           |:|...::||        ...|| ||.|:     ...|.....:
Mouse   402 APERASITKEPASTEAAVNKVLRKVIESEKLDEATEGKRLGFSLNTRATH-----TFPETRSQRK 461

  Fly   278 AS--------ILHDTDLLVAPNSPAESSPDEELMALQLGKKLAQVLG-----SGAGSPLTPGTME 329
            |.        :|.|....|.|:|| :...||:....|:...|..|..     |.|...|:| ...
Mouse   462 AGLPQSGHKFLLLDLPHTVGPDSP-QPKCDEKKPTPQVPTALGMVFNNSSPQSSAHKRLSP-VPS 524

  Fly   330 PCAAGSGSPL------------ANGE-LFNVSKAKKVELQNLSSRFTAAVTQTPPGVTSSTPNES 381
            |.:....||.            :.|| :||...::|   .::||.|.:|.|..|...|..|
Mouse   525 PLSPRCPSPQQHHRILLLPPLPSEGEVVFNEYPSRK---NDVSSGFPSADTLEPSSTTKVT---- 582

  Fly   382 GVTGPAGPLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAASENVEDDTAPLPLPPPPPGFGT 446
                              ||:.....|.::|||.:.|:..|......|..||| |....|||..:
Mouse   583 ------------------ETKGASPTSLRASQTWLVSEEASEKGLGPEKITAP-PQHQLPPGIAS 628

  Fly   447 PTTPLLSSNVLKKVASFTVEKSSAGNNSSNPPNLCPTSDETTLLATPCSSSLTVATLPPEIAVGA 511
            ...|                              |....|.|....|
Mouse   629 EGFP------------------------------CDNFKEQTAKDLP------------------ 645

  Fly   512 AAGGVAGGAGSRRGSSYVP-----EKLSFAAYEKFEGQMLIKWLISTMQSNPKSSSGDANQELFN 571
                      ::.|..:||     ....|..:|:.|                |:|    ..||:
Mouse   646 ----------NKDGGVWVPGYRAGPPCPFLLHEEKE----------------KTS----RSELY- 679

  Fly   572 TLALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTSLPLTPGKLDKVAAWPFSSTP 636
                                   ||  .:|        .:.||.....|||:|.  |.||...|.
Mouse   680 -----------------------LD--LNP--------DQSPTEQDDRTPGRLQ--AVWPPPKTK 709

  Fly   637 S-----GIRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLLNCTTLAEVHAV 696
            .     |::..|            |...|.|........:..:|||...:.:..:   :...||:
Mouse   710 DTEEKVGLKYTE------------AEYQAAILHLKREHKEEIETLQAQFELKTFH---IRGEHAL 759

  Fly   697 VN-ELLSSVDEPPRRPSKRCVNLTELLNASEATVYEYNKTGAEGC-VKSFTDAETQTESE----D 755
            |. .|..:::...::..||.....|:.:...:|        .:.| .|:|.:...||:.|    .
Mouse   760 VTARLEEAIENLKQQLGKRREGCEEMRDVCIST--------DDDCSPKAFRNVCIQTDRETFLKP 816

  Fly   756 CEGTCKCGQSS-----------TKVSDNESAKE-----------DGEKPHAVAPPPPPPPPPLHA 798
            |:...|..:||           |::|.::.:|:           .....|.::||.||.||||..
Mouse   817 CDAESKATRSSQIVPKKLTISLTQLSPSKDSKDIHAPFQTREGTSSSSQHKISPPAPPTPPPLPP 881

  Fly   799 FVAPPPPP-PP-----PPPPP-PPLANYGAPPPPPPP-----PPGSGSAPPPPPPAPIEG----- 846
            .:.||||| ||     ||.|| ||:.....|||||||     ||..|..||||||.|:..
Mouse   882 PLIPPPPPLPPGLGPLPPAPPIPPVCPVSPPPPPPPPPPTPVPPSDGPPPPPPPPPPLPNVLALP 946

  Fly   847 GGGIPPPPPPMSASPSKTTISPAPLPDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPP 911
            ..|.||||||    |....::|.|.|..:.|.....:...||.|:.|..||:|||||||
Mouse   947 NSGGPPPPPP----PPPPGLAPPPPPGLSFGLSSSSSQYPRKPAIEPSCPMKPLYWTRI------ 1001

  Fly   912 APRPPSVANSTDSTENSGSSPDEPPAANGADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSR- 975
                    ...|.::               ||.||       :|..:||..:.:..||..|||:
Mouse  1002 --------QINDKSQ---------------DAAPT-------LWDSLEEPHIRDTSEFEYLFSKD 1036

  Fly   976 ---QAIAPVSKPKELKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEAL 1037
               |...|:|:..|.|.|..|.||:||.:||:.|||:..|||:...:|:.||:.:|.|||.||.|
Mouse  1037 TTQQKKKPLSEAYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFTVDDSVVDLETL 1101

  Fly  1038 QHMSNIQATEDELQRIKE----AAGGDIP-LDHPEQFLLDISLISMASERISCIVFQAEFEESVT 1097
            ..:...:|.||||.:|::    :...|:. ||.|||||.:::.|...:||..||:|:|.|.|.:|
Mouse  1102 AALYENRAQEDELTKIRKYYETSKEEDLKLLDKPEQFLHELAQIPNFAERAQCIIFRAVFSEGIT 1166

  Fly  1098 LLFRKLETVSQLSQQLIESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKES 1162
            .|.||:|.|::.|:.|:..:.:|.:.::||..|||||||||.||||||::|:||.|||||||:::
Mouse  1167 SLHRKVEIVTRASKGLLHMKSVKDILALILAFGNYMNGGNRTRGQADGYSLEILPKLKDVKSRDN 1231

  Fly  1163 HTTLLHFIVRTYI-------------AQRRKE--------GVHP-----LEIR---------LPI 1192
            ...|:.::|:.|:             :.|.|:        .|||     ||::         .|:
Mouse  1232 GMNLVDYVVKYYLRYYDQCKHHDQEASCRGKDLFSLYFHIAVHPQRKSGLELKQEAGTDKSVFPL 1296

  Fly  1193 PEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEFVEGADKSM 1257
            |||.|...|:|:.||::.:.:..|.::....::....|...|..|.::|||.|:|||.:.|.|..
Mouse  1297 PEPQDFFLASQVKFEDLLKDLRKLKRQLEASEQQMKLVCKESPREYLQPFKDKLEEFFKKAKKEH 1361

  Fly  1258 AKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFKDIWKKEITSLLNE 1322
            ......|:..:..|..|:.::...||...   .:.||...|..|..|.:|||.|||:|..::..|
Mouse  1362 KMEESHLENAQKSFETTVGYFGMKPKTGE---KEVTPSYVFMVWFEFCSDFKTIWKRESKNISKE 1423

  Fly  1323 LMK--KSKQAQIESRRNVSTKVEKSGRISLKERMLMRRS 1359
            .:|  ::..:::.|.:.|.|| :.:...|||||:..:.:
Mouse  1424 RLKMAQASVSKLTSEKKVETK-KINPTASLKERLRQKEA 1461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	161/470 (34%)
Fmn1	NP_034360.2	Microtubule-binding	1..624		107/514 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..192		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..329		23/108 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..413		7/39 (18%)
		Mediates interaction with alpha-catenin	458..842		103/548 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..534		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..598		14/63 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..713		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..897		18/56 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	913..989		31/79 (39%)
		FH2	984..1417	CDD:214697	161/471 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1446..1466		5/16 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2132
eggNOG	1	0.900	-	-		E1_KOG1922
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002764
OrthoInspector	1	1.000	-	-		otm43174
orthoMCL	1	0.900	-	-		OOG6_104364
Panther	1	1.100	-	-	LDO	PTHR13037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4961
SonicParanoid	1	1.000	-	-		X2588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.840