DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment capu and Fmn2

DIOPT Version :9

Sequence 1:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster
Sequence 2:	XP_038947361.1	Gene:	Fmn2 / 100360457	RGDID:	2322099	Length:	1588	Species:	Rattus norvegicus

Alignment Length:	1738	Identity:	430/1738 - (24%)
Similarity:	631/1738 - (36%)	Gaps:	568/1738 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RAANVDEKSPPGGASLVRMGITGGGGAGEVGVALSERRGSRVRVLSRLMGQKRI---------RE 62
            |.|...:|:.....:|.:.| .||||:||.....| :..||..|.|.|..:|.:         ||
  Rat    31 RDAETTKKASGSKKALGKHG-KGGGGSGETSKKKS-KSDSRASVFSNLRIRKNLGKGKGAGDSRE 93

  Fly    63 AFLHSPKL------------GSSSEVNLQGAGNGSSDWIAAET-EVEH----------------- 97
            ..|.|..|            ..:.:::|.....|.||...|:. ||.|
  Rat    94 DVLDSQALPIGELDSAHSIVTKTPDLSLSAEETGLSDTECADPFEVIHPGGSRPAEAGVGIQAIA 158

  Fly    98 GQLDCSAEPADFHDVVSLDCTDSLEYHNCSSDECCYASNDTLTE-RQNRELQQRQRQHHHHHHHI 161
            ..|:.:|...|.....|...||...:|:.:..|      |.|:: :|...|||:|:|
  Rat   159 EDLETAAGAQDGQRTSSGSDTDIYSFHSATEQE------DLLSDIQQAIRLQQQQQQ-------- 209

  Fly   162 HNAHESHHHYPYDRRSLCTSCSSN-----DSLFTDPVDELIISKHYLNTAAKEHNNPKAKRDRPL 221
                         ::.|....|..     .::...|...|.:.:..|.|::      :||:|
  Rat   210 -------------QQKLLLQDSEEPAAPPTAISPQPGAFLGLDQFLLGTSS------EAKKD--- 252

  Fly   222 SEISVTSVDTLSPNTAKAVLELQKRCRADKLACLSLTRVTYLSIANDLQEVEEPDRASILHD--T 284
             .:....|....|.|.|:::..........||.                  |.|..|: .|.  |
  Rat   253 -TVQAPPVRPDLPETTKSLVPEHPPSSGSHLAS------------------ETPGYAT-AHSAVT 297

  Fly   285 DLLVAPNSPAESSPDEELMALQLGKKLAQVLGSGAGSPLTPGTMEPCA------AGSGSPLANGE 343
            |.|   :|||.:.|  |:.....|:..|.|..:|.|.     |.|.|.      |..|||   ||
  Rat   298 DTL---SSPAFTFP--EVPEAGPGEGAAGVPPAGTGD-----TDEECEEDAFEDAPRGSP---GE 349

  Fly   344 LFNVSKAKKVELQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAGPLGATTSSPSLETQSTVIIS 408
            .:      ..|::..|.|    :.:.|         |.|:.||..|  |..|.|.....|.....
  Rat   350 EW------APEVEEASQR----LEEEP---------EEGMRGPIIP--AVASLPGSPAPSPRCFK 393

  Fly   409 FKSSQTP--VQSQTNSAASENVEDDTAPLPLP-----PPPPGFGTPTTPLLSSNVLKKVASFTVE 466
            .....||  :::.|...:|.|.....:|...|     |.|....:|.|.|.|:....|  ...:|
  Rat   394 PYPLITPCYIKTTTRQLSSPNHSPSQSPNQSPRIKKRPDPSVSRSPRTALASAATPAK--KHRLE 456

  Fly   467 KSSAGNNSSNPPNLCPTSDETTLLA--TP-CSSSLTVATLPPEIAVGAAAGGVAGG----AGSRR 524
            ....|       .|..::|.|..|.  || ...|:.:      :..||.|....||    |....
  Rat   457 GGLVG-------GLSRSADWTEELGARTPGAGGSVHL------LGRGATADDSGGGSPVLAAKAP 508

  Fly   525 GSSYVPEKLSFAAYEKFEGQMLIKWLISTMQSNPKSSSGDANQELFNTLALQFCNNLKYVGVLKQ 589
            |:....:...    ..|.|:.|::.|.|..::.|...            |.:||:.:..:|:|..
  Rat   509 GAPATADGFQ----NVFTGRTLLEKLFSQQENGPPEE------------AEKFCSRIIAMGLLLP 557

  Fly   590 IS-------NEHLDCGFSPY---EMYQWTHTEQPTTSLPLTPGKLDK--VAAWPFSSTP------ 636
            .|       |::.....:|:   ::|.|....|||.|:..:.|:..:  .:.|..|..|
  Rat   558 FSDCFREPCNQNAGSSSAPFDQDQLYTWAAVSQPTHSMDYSEGQFPRREPSTWRPSKLPDEEPSP 622

  Fly   637 --------SGIRALESASLASLGAGGVAGSLATIATASTASSDNQ--KTLQQILKK--------- 682
                    |.|  |||....|   .||...:..:.:...|:...|  :|::.:..|
  Rat   623 KDIDTEPQSSI--LESPKKCS---NGVQQEVFDVKSEGQATVIQQLEQTIEDLRTKIAALEKQYP 682

  Fly   683 -------RLLN-CTTLAEV-------HAVV---------NELLSSVDE--------PPRRP---- 711
                   ||.| .|..|:|       |..|         ..:.:|..|        ||:.|
  Rat   683 SLDLEGPRLENGLTASADVSLDALGLHGKVAHPPRTLEAKSIQTSPTEEDRILTLPPPKAPPEGL 747

  Fly   712 ---------------------SKRCVNLTELLNASEATVYEYNKTGAEGCVKSFTD--------- 746
                                 :|.|..::.:::....:|    :..|:..::|.:.
  Rat   748 PGPPAAESGESALLTSSSGPQTKFCSEISLIVSPRRISV----QLDAQPAMQSTSQLPPPPSLLG 808

  Fly   747 -------------AETQTESE-----DCEGTCK--------CGQSS------------------- 766
                         .|.:|..|     ..|.:|.        |.:||
  Rat   809 ADSQGQPSQPSLHPELETSHEHSVFSSFENSCNIPPAPPLPCTESSSFMPGLGTAIPPPPCLSDI 873

  Fly   767 ---------------TKVSDNESAKEDGEKPHAVAP--PPPPPPPPLHAFVAPPPP--------- 805
                           |.:...:......:.|....|  |||||||||.....||||
  Rat   874 TVPALPSPTAPALQLTNLQGPQMLPTPPQPPSLSGPGVPPPPPPPPLPGVGIPPPPPLPGMGIPP 938

  Fly   806 ----------------------------------------------------------------- 805

  Rat   939 PPPLPGMGIPPPPPLPGVEIPPPPPLPGGGIPPPPPLPGGGIPPPPPLPGGGIPPPPPPLPGVGI 1003

  Fly   806 ----------------------PPPPPPPPPPLANYGAPPP--------PPPPP-PGSGSAPPP- 838
                                  |||||||||||...|.|||        ||||| ||.|..|||
  Rat  1004 PPPPPLPGVGIPPPPPLPGVVIPPPPPPPPPPLPGVGIPPPPPLPGMGIPPPPPLPGVGIPPPPA 1068

  Fly   839 -----------------PPPAPIEGGGGIPPPPP------PMSASPSKTTISPA---------PL 871
                             |||||...|.||||||.      |:|:....:|:..|         ||
  Rat  1069 LPGVAIPPPPPLPGMGVPPPAPPPPGAGIPPPPQLPGSGLPLSSQDGSSTLPAAPQGCGFLFPPL 1133

  Fly   872 PDPAEGNWFHRTNTMRKSAVNPPKPMRPLYWTRIVTSAPPAPRPPSVANSTDSTENSGSSPDEPP 936
            |....|...::....||..:.|.:||:|||||||                     ...|..|..|
  Rat  1134 PTGLFGLGMNQDRVARKQPIEPCRPMKPLYWTRI---------------------QLHSKRDSSP 1177

  Fly   937 AANGADAPPTAPPATKEIWTEIEETPLDNIDEFTELFSRQAIAPVSKPKELKVKRAKS---IKVL 998
            :.               ||.:|||..:| ..||.||||:.|:....||....:.:.|:   :|:|
  Rat  1178 SL---------------IWEKIEEPSID-CHEFEELFSKTAVKERKKPISDTISKTKAKQVVKLL 1226

  Fly   999 DPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQRI---------K 1054
            ..:||:.|||:..|||:...:|:||:.::|.|||.||.||.:...:|..|||::|         |
  Rat  1227 SNKRSQAVGILMSSLHLDMKDIQHAVVNLDNSVVDLETLQALYENRAQSDELEKIEKHSRSSKDK 1291

  Fly  1055 EAAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQLIESEDL 1119
            |.|..   ||.|||||.::|||...|||:.||:||:.|.||:..:.||||.:.:|.:.|.....:
  Rat  1292 ENAKS---LDKPEQFLYELSLIPNFSERVFCILFQSTFSESICSIRRKLELLQKLCETLKNGPGV 1353

  Fly  1120 KLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQRRKEGVH 1184
            ..|..::|..|||||.||:.|||||||.||||.|||||||.::..:||.:|| :|..:...|...
  Rat  1354 MQVLGLVLAFGNYMNAGNKTRGQADGFGLDILPKLKDVKSSDNSRSLLSYIV-SYYLRNFDEDAG 1417

  Fly  1185 PLEIRLPIPEPADVERAAQMDFEEVQQQIFDLNKKFLGCKRTTAKVLAASRPEIMEPFKSKMEEF 1249
            ..:...|:.||.::.:|:||.||:.|:.:..|.|....|:....||...|..|..:|||..||:|
  Rat  1418 KEQCVFPLSEPQELFQASQMKFEDFQKDLRKLKKDLKACEVEAGKVYQVSSEEHKQPFKENMEQF 1482

  Fly  1250 VEGADKSMAKLHQ-----SLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEYWTNFTNDFK 1309
            :     |.||:.|     :|.|....||||..:|...||   |...:.:|:.||..|..|::|||
  Rat  1483 I-----SQAKIDQETQETALTETHKCFLETTAYYFMKPK---LGEKEVSPNVFFSVWHEFSSDFK 1539

  Fly  1310 DIWKKEITSLLNELMKKSKQAQIESRRNVSTKVEKSGRISLKERMLMR 1357
            |.||||...:|.|.:|::::...:.:.....||:......:|.::.|:
  Rat  1540 DSWKKENKLILQERVKEAEEVCRQKKGKSLYKVKPRHDSGIKAKISMK 1587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
capu	NP_001137784.1	FH2	888..1315	CDD:214697	165/443 (37%)
Fmn2	XP_038947361.1	PHA03247	<221..767	CDD:223021	131/644 (20%)
Fmn2	XP_038947361.1	FH2	1149..1539	CDD:396655	161/438 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002764
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104364
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2588
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.900