DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and LRRIQ1

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_011537119.1	Gene:	LRRIQ1 / 84125	HGNCID:	25708	Length:	1760	Species:	Homo sapiens

Alignment Length:	840	Identity:	161/840 - (19%)
Similarity:	286/840 - (34%)	Gaps:	272/840 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 IDSYLKIETLSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIE 112
            ::|...::.|.|..|||:...|:|....:..|:.|.|.:..:||::.|..|::|.|:||.:..:.
Human   965 LESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELP 1029

  Fly   113 HLNTNVNLECLNLADNSIGSISDMS--YLRNLKELYLHGNRLTHLRQCDKCLP----TSLETLTL 171
            .|...|.|..|:|.||||.::...|  :|..|:.:.:..|.||      |.:|    .|||.|.:
Human  1030 SLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLT------KIVPLFHFVSLEKLDV 1088

  Fly   172 AKNSINDLN------EICTLSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGF 230
            :.|.::||.      :.|...|     .:|:..||.:...|      :|..:|....:|:.::|.
Human  1089 SHNCLSDLKSAIKWFDACYSLH-----ELSLTGNPLLQETN------WRDSLLKVLPALRILNGN 1142

  Fly   231 VVDPIESLKAE---------WL----------------YSQGRGRQFRVGEQQGLAKYLSSVCPL 270
            :::.....:.|         :|                |..|:|..|.:...:.|..|.
Human  1143 ILNSNSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYF------ 1201

  Fly   271 VGKALENENDRKLRLILSKAQH-HQRQLQEEIMDNANSSASTSPSSHRKKPTSRIQSPRFSRLSG 334
                      :||.::.::.:| |:|                ...:..||..|..|
Human  1202 ----------KKLMILSTEYRHAHER----------------GDVTITKKDESEAQ--------- 1231

  Fly   335 RQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSLAGSGMSSSVTTKTY 399
                             .|.:...|         |.|.::|    |..:|.|..|...|
Human  1232 -----------------KNHLAPTN---------SDSTLQN----GVFYSCAREGEPDS------ 1260

  Fly   400 NSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAAVAQRVTVTALNPQ 464
                         |...:.::....|..||:.::                         |..|.:
Human  1261 -------------PDIPEKWMDSVSSHSPLSKSA-------------------------TCENME 1287

  Fly   465 LHKTKI---NKNKDNKL-NLPRVRSP--------QLKRNQSPTSSPRRMANKCSADNMQAPEKLQ 517
            ....:|   .|.:|:|. ::|.:|.|        .|.||.               .|::..||:.
Human  1288 GRHQEILVCQKREDSKASSIPTIRIPFKEVVMTNSLLRNH---------------QNIEPSEKIM 1337

  Fly   518 QSAVLAD---------SGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQ-QVDNNLNCQ 572
            .:.|:..         ...|||          :|..............:|..||: :.:|.:|
Human  1338 AAVVIQSYWRGYLMRRQTHFST----------RLHTAATEGLPNSSIKNQTILKKGKRENIVN-- 1390

  Fly   573 DRLIEHVTESSAVTIQKMWRGYHTRKKTNKDIAERLQRRRTQEYIEQLGKDMLLTKAQLENE--- 634
               |....|.:|:.||.:|:|:..|||....:.........:||.|...:|.:..:|.||.|
Human  1391 ---IRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDLEDFIFDEAALEEEWLA 1452

  Fly   635 ----RKIQQLQMQAINALWKKV-STMEVDPK--GIPAAAEQ----GEDSNGGGSGHLSLDQNSAA 688
                |...|..:.:....|.|: ..::.|..  .:|:...|    .:..|...|.|...:..|
Human  1453 LDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQAWLCNDKENLSSSEHTQFNSRS-- 1515

  Fly   689 VVNDLAKRCTMLTDQVQMLQSSIGTIVNCLTMVCNLPQDAIKKQAE---IIDCSSTQTDLIAVHT 750
                 ..:.:..|.:.:..:.|:            |..:..||.:|   ..|.|:.|..|
Human  1516 -----ENKTSSWTPESKTSRKSL------------LKSEKEKKISEEWGFKDISTAQQML----- 1558

  Fly   751 PQIEDLTNFPFTKTRPST--LALESKHEAALACPKIDELNDVDLKETQEDS--ENLDKDP 806
            .:.:.:.:....|...||  |||...:|..::.||..:     :.:.:.|.  |.:::||
Human  1559 KRAQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPK-----MVQPRRDGYFEGIEEDP 1613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		leucine-rich repeat	32..53	CDD:275380	1/4 (25%)
		LRR_RI	<49..189	CDD:238064	45/151 (30%)
		LRR_4	76..115	CDD:289563	11/38 (29%)
		leucine-rich repeat	76..97	CDD:275380	6/20 (30%)
		LRR_8	97..152	CDD:290566	18/56 (32%)
		LRR_4	97..137	CDD:289563	14/39 (36%)
		leucine-rich repeat	98..119	CDD:275380	6/20 (30%)
		leucine-rich repeat	120..141	CDD:275380	9/22 (41%)
		LRR_8	140..200	CDD:290566	16/69 (23%)
		leucine-rich repeat	142..165	CDD:275380	6/26 (23%)
		leucine-rich repeat	166..190	CDD:275380	8/29 (28%)
		IQ	581..599	CDD:197470	7/17 (41%)
LRRIQ1	XP_011537119.1	DUF4515	164..343	CDD:291649
		LRR_4	818..856	CDD:289563
		leucine-rich repeat	820..841	CDD:275380
		leucine-rich repeat	842..862	CDD:275380
		leucine-rich repeat	863..884	CDD:275380
		leucine-rich repeat	885..920	CDD:275380
		leucine-rich repeat	921..970	CDD:275380	1/4 (25%)
		LRR_RI	<963..1095	CDD:238064	41/135 (30%)
		leucine-rich repeat	971..992	CDD:275380	7/20 (35%)
		leucine-rich repeat	993..1014	CDD:275380	6/20 (30%)
		leucine-rich repeat	1015..1036	CDD:275380	6/20 (30%)
		LRR_8	1037..1091	CDD:290566	19/59 (32%)
		leucine-rich repeat	1037..1060	CDD:275380	9/22 (41%)
		leucine-rich repeat	1083..1108	CDD:275380	7/24 (29%)
		leucine-rich repeat	1109..1135	CDD:275380	7/36 (19%)
		IQ	1338..1354	CDD:197470	1/15 (7%)
		IQ	1394..1415	CDD:197470	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910