Protein Alignment Cep97 and DRC3

DIOPT Version :10

• Sequence 1: NP_608811.2
• Gene: Cep97 / 33610
• FlyBaseID: FBgn0031575
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_011522320.1
• Gene: DRC3 / 83450
• HGNCID: 25384
• Length: 562
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 90/443 - (20%)
• Similarity: 152/443 - (34%)
• Gaps: 148/443 - (33%)

  Fly   103 PKHKKILSAPINLG-----EMAATQEIANDDIQSIWVVQRDDSLKVDSKKL---------EKAEA 153
            |::...||....||     .::||:::.:........|....:||...|.|         .:|:.
Human   671 PQNVTKLSVKDRLGFVSKPSVSATEKVLSTSTGLTKTVYNPAALKAAQKTLLVSTSAVDNNEAQK 735

  Fly   154 KRQQKLEKRQEVKAAAAATAATAPVLQ--TATASQVISKKDNKMESKGTNRSMDIRIDNFDVSFG 216
            |:|:.|:.:|:|:      .....:|:  ..|...:||    |:|...|.:|.|
Human   736 KKQEALKLQQDVR------KRKQEILEKHIETQKMLIS----KLEKNKTMKSED----------- 779

  Fly   217 DKTLLQNADLLLASGRRYGFVGRNGLGKTTLLKMISGKQLQIPSHISVLHVEQEVVGDDTTALDS 281
                                       |..::|.:.    .:..:|:.|..|.:..........|
Human   780 ---------------------------KAEIMKTLE----VLTKNITKLKDEVKAASPGRCLPKS 813

  Fly   282 VLEVDTVRTELLQRERDLNAQIAAGSTDANLGNELSEVYNQLQTIEADKAPARASIILNGLGFTK 346
            :.....::.|||..|.||..::.||..    ..||...|.:|| :||    |:..|:.:|.|  :
Human   814 IKTKTQMQKELLDTELDLYKKMQAGEE----VTELRRKYTELQ-LEA----AKRGILSSGRG--R 867

  Fly   347 EMQARATRTFSGGWRMRLALARALFSKPELLLLDEPTNMLDIKAIIWLENYLQNWPTTLLVVSHD 411
            .:.:|......|..|.| ...|.:   |...::|.....|:|.|.                ...|
Human   868 GIHSRGRGAVHGRGRGR-GRGRGV---PGHAVVDHRPRALEISAF----------------TESD 912

  Fly   412 RNFLDTVPTDILY------------LHSMRIETFKGNYEQFDKTRTER-----HKAQRREYEAQL 459
            |.  |.:|....|            ||:  :.||        |||.|.     |.|:.:..:.:|
Human   913 RE--DLLPHFAQYGEIEDCQIDDSSLHA--VITF--------KTRAEAEAAAVHGARFKGQDLKL 965

  Fly   460 AHRNHVQEFIDRFRYNANRAASVQSKIKMLEKLPELKPVEKEIEVTLKFPEVE 512
            |....|           ...::|:::        |::|.|:|| :.|.|.|.|
Human   966 AWNKPV-----------TNISAVETE--------EVEPDEEEI-IPLSFHEFE 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		PPP1R42	13..229	CDD:455733	27/141 (19%)
		leucine-rich repeat	32..53	CDD:275380
		leucine-rich repeat	76..97	CDD:275380
		leucine-rich repeat	98..119	CDD:275380	5/20 (25%)
		leucine-rich repeat	120..141	CDD:275380	3/20 (15%)
		leucine-rich repeat	142..165	CDD:275380	8/31 (26%)
		leucine-rich repeat	166..190	CDD:275380	3/25 (12%)
		IQ	581..599	CDD:197470
DRC3	XP_011522320.1	PPP1R42	75..>208	CDD:455733
		leucine-rich repeat	87..108	CDD:275378
		leucine-rich repeat	109..130	CDD:275378
		leucine-rich repeat	131..152	CDD:275378
		leucine-rich repeat	153..177	CDD:275378
		leucine-rich repeat	178..189	CDD:275378