DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and CEP97

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_078824.2	Gene:	CEP97 / 79598	HGNCID:	26244	Length:	865	Species:	Homo sapiens

Alignment Length:	913	Identity:	269/913 - (29%)
Similarity:	428/913 - (46%)	Gaps:	207/913 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EKHVLNLSKQKLKK----VPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYG 69
            |..|:|.|.|.|:|    :|.:.|.|:   ||||:|::.|::|::...::..||:|.|:|:||.|
Human    14 EGSVVNWSGQGLQKLGPNLPCEADIHT---LILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMG 75

  Fly    70 VCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSIS 134
            |.:|..||.|||..|.|..:|||||.:||..|||.|||:|.:|.:|:...|:.|:|:||:|..|.
Human    76 VAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIG 140

  Fly   135 DMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADN 199
            |:|.|.:||.|.||||.:|.||.....||.||..|:||:|.|.|||||..|:.|:.|..:||.:|
Human   141 DLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNN 205

  Fly   200 PCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYL 264
            |||....|:.||||||::::||::|:.:||:|:...||||||||||||:||.:|.|:...|.:||
Human   206 PCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYL 270

  Fly   265 SSVCPLVGK-ALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSP-------SSHRKKPT 321
            ::||||... .|:...|.||..||||.:.|||||.     |.:.:...||       :|...:.:
Human   271 ATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLM-----NQSQNEELSPLVPVETRASLIPEHS 330

  Fly   322 SRIQSPRFSRLSGRQGSPESMVNSYHG-NSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSL 385
            |.:|..:.|    ::..|...|||:.| ||:::.:.:                  :||:
Human   331 SPVQDCQIS----QESEPVIQVNSWVGINSNDDQLFA------------------VKNN------ 367

  Fly   386 AGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETL--MSPDV- 447
                ..:||.|..|:..:....:|..:  .|:...|.      |::.|..:||...|  :||.|
Human   368 ----FPASVHTTRYSRNDLHLEDIQTD--EDKLNCSL------LSSESTFMPVASGLSPLSPTVE 420

  Fly   448 ----------CPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRMA 502
                      ....||.. :|..|..|:    ::|.::..|......|.|:.|::..|....:
Human   421 LRLQGINLGLEDDGVADE-SVKGLESQV----LDKEEEQPLWAANENSVQMMRSEINTEVNEK-- 478

  Fly   503 NKCSADNMQAPEKLQQSAVLADSGG----FSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQ 563
                |..:..||....||:|.|...    |....:.:|.:|:|        .:..|..::|.:.|
Human   479 ----AGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKK--------PENTQPENKETISQ 531

  Fly   564 QVDNNLNC----------QDRLIEHVTESSAVTIQKMWRGYHTR--KKTNKDIAERLQRRRTQEY 616
            .....|..          ||::.......:|..:|..|||::.|  ....||:...::.||.||:
Human   532 ATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEH 596

  Fly   617 IEQLGKDMLLTKAQLENERKIQQLQMQAINALWKKVSTME-----VDPK------GIPAAAE--- 667
            |..|..::...:.:.:.||..:.:|.:|...||.:|.:::     ||.:      .:|..:.
Human   597 IVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTLV 661

  Fly   668 --------QGEDSNGGGSGHLSLDQNSA-AVVNDLAKR------------CTMLTDQVQMLQSSI 711
                    |.::|        |.|||:. .:.:|:|.:            .:.||:||..||.|:
Human   662 PSKHPLFTQSQES--------SCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSL 718

  Fly   712 ----GTIVNCLTMVCNLPQDAIK--KQAEIIDCSSTQTD------------------LIAVHTPQ 752
                .:.....:.:.....|.::  |::::.|.|....:                  |.:|.  |
Human   719 DFEKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQ--Q 781

  Fly   753 IEDL---TNFPFTKTRPSTLALESKHEAALAC--PKIDELND---VD------------LKETQE 797
            :||.   |||. |:||.|.|     |   :||  .::|.|:|   ||            :.:|||
Human   782 LEDADERTNFD-TETRDSKL-----H---IACFPVQLDTLSDGASVDESHGISPPLQGEISQTQE 837

  Fly   798 DSE 800
            :|:
Human   838 NSK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	8/23 (35%)
		leucine-rich repeat	32..53	CDD:275380	7/20 (35%)
		LRR_RI	<49..189	CDD:238064	68/139 (49%)
		LRR_4	76..115	CDD:289563	22/38 (58%)
		leucine-rich repeat	76..97	CDD:275380	12/20 (60%)
		LRR_8	97..152	CDD:290566	28/54 (52%)
		LRR_4	97..137	CDD:289563	19/39 (49%)
		leucine-rich repeat	98..119	CDD:275380	10/20 (50%)
		leucine-rich repeat	120..141	CDD:275380	10/20 (50%)
		LRR_8	140..200	CDD:290566	29/59 (49%)
		leucine-rich repeat	142..165	CDD:275380	12/22 (55%)
		leucine-rich repeat	166..190	CDD:275380	13/23 (57%)
		IQ	581..599	CDD:197470	6/19 (32%)
CEP97	NP_078824.2	leucine-rich repeat	17..37	CDD:275380	7/19 (37%)
		LRR 1	37..58		9/23 (39%)
		leucine-rich repeat	38..59	CDD:275380	8/23 (35%)
		LRR 2	59..80		9/20 (45%)
		leucine-rich repeat	60..81	CDD:275380	10/20 (50%)
		LRR_8	63..114	CDD:290566	29/50 (58%)
		LRR_RI	<78..200	CDD:238064	61/121 (50%)
		LRR 3	81..102		12/20 (60%)
		leucine-rich repeat	82..103	CDD:275380	12/20 (60%)
		LRR_8	103..156	CDD:290566	26/52 (50%)
		LRR 4	103..124		11/20 (55%)
		leucine-rich repeat	104..125	CDD:275380	10/20 (50%)
		LRR_4	124..161	CDD:289563	18/36 (50%)
		LRR 5	125..146		9/20 (45%)
		leucine-rich repeat	126..147	CDD:275380	10/20 (50%)
		LRR_8	147..206	CDD:290566	29/58 (50%)
		LRR 6	147..168		10/20 (50%)
		leucine-rich repeat	148..171	CDD:275380	12/22 (55%)
		LRR 7	171..192		12/20 (60%)
		leucine-rich repeat	172..196	CDD:275380	13/23 (57%)
		LRR 8	196..205		3/8 (38%)
		CCP110-binding	300..750		105/521 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..529		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..769		6/53 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159362
Domainoid	1	1.000	63	1.000	Domainoid score	I10296
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2775
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264004at2759
OrthoFinder	1	1.000	-	-		FOG0007484
OrthoInspector	1	1.000	-	-		oto91781
orthoMCL	1	0.900	-	-		OOG6_107805
Panther	1	1.100	-	-	LDO	PTHR45973
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8601
SonicParanoid	1	1.000	-	-		X6361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930