Protein Alignment Cep97 and CEP97

DIOPT Version :10

• Sequence 1: NP_608811.2
• Gene: Cep97 / 33610
• FlyBaseID: FBgn0031575
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_078824.2
• Gene: CEP97 / 79598
• HGNCID: 26244
• Length: 865
• Species: Homo sapiens
• Alignment Length: 913
• Identity: 269/913 - (29%)
• Similarity: 428/913 - (46%)
• Gaps: 207/913 - (22%)

  Fly     9 EKHVLNLSKQKLKK----VPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYG 69
            |..|:|.|.|.|:|    :|.:.|.|:   ||||:|::.|::|::...::..||:|.|:|:||.|
Human    14 EGSVVNWSGQGLQKLGPNLPCEADIHT---LILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMG 75

  Fly    70 VCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSIS 134
            |.:|..||.|||..|.|..:|||||.:||..|||.|||:|.:|.:|:...|:.|:|:||:|..|.
Human    76 VAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIG 140

  Fly   135 DMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADN 199
            |:|.|.:||.|.||||.:|.||.....||.||..|:||:|.|.|||||..|:.|:.|..:||.:|
Human   141 DLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNN 205

  Fly   200 PCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYL 264
            |||....|:.||||||::::||::|:.:||:|:...||||||||||||:||.:|.|:...|.:||
Human   206 PCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYL 270

  Fly   265 SSVCPLVGK-ALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSP-------SSHRKKPT 321
            ::||||... .|:...|.||..||||.:.|||||.     |.:.:...||       :|...:.:
Human   271 ATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLM-----NQSQNEELSPLVPVETRASLIPEHS 330

  Fly   322 SRIQSPRFSRLSGRQGSPESMVNSYHG-NSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSL 385
            |.:|..:.|    ::..|...|||:.| ||:::.:.:                  :||:
Human   331 SPVQDCQIS----QESEPVIQVNSWVGINSNDDQLFA------------------VKNN------ 367

  Fly   386 AGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETL--MSPDV- 447
                ..:||.|..|:..:....:|..:  .|:...|.      |::.|..:||...|  :||.|
Human   368 ----FPASVHTTRYSRNDLHLEDIQTD--EDKLNCSL------LSSESTFMPVASGLSPLSPTVE 420

  Fly   448 ----------CPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRMA 502
                      ....||.. :|..|..|:    ::|.::..|......|.|:.|::..|....:
Human   421 LRLQGINLGLEDDGVADE-SVKGLESQV----LDKEEEQPLWAANENSVQMMRSEINTEVNEK-- 478

  Fly   503 NKCSADNMQAPEKLQQSAVLADSGG----FSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQ 563
                |..:..||....||:|.|...    |....:.:|.:|:|        .:..|..::|.:.|
Human   479 ----AGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKK--------PENTQPENKETISQ 531

  Fly   564 QVDNNLNC----------QDRLIEHVTESSAVTIQKMWRGYHTR--KKTNKDIAERLQRRRTQEY 616
            .....|..          ||::.......:|..:|..|||::.|  ....||:...::.||.||:
Human   532 ATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEH 596

  Fly   617 IEQLGKDMLLTKAQLENERKIQQLQMQAINALWKKVSTME-----VDPK------GIPAAAE--- 667
            |..|..::...:.:.:.||..:.:|.:|...||.:|.:::     ||.:      .:|..:.
Human   597 IVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTLV 661

  Fly   668 --------QGEDSNGGGSGHLSLDQNSA-AVVNDLAKR------------CTMLTDQVQMLQSSI 711
                    |.::|        |.|||:. .:.:|:|.:            .:.||:||..||.|:
Human   662 PSKHPLFTQSQES--------SCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSL 718

  Fly   712 ----GTIVNCLTMVCNLPQDAIK--KQAEIIDCSSTQTD------------------LIAVHTPQ 752
                .:.....:.:.....|.::  |::::.|.|....:                  |.:|.  |
Human   719 DFEKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQ--Q 781

  Fly   753 IEDL---TNFPFTKTRPSTLALESKHEAALAC--PKIDELND---VD------------LKETQE 797
            :||.   |||. |:||.|.|     |   :||  .::|.|:|   ||            :.:|||
Human   782 LEDADERTNFD-TETRDSKL-----H---IACFPVQLDTLSDGASVDESHGISPPLQGEISQTQE 837

  Fly   798 DSE 800
            :|:
Human   838 NSK 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	8/23 (35%)
		PPP1R42	13..229	CDD:455733	101/219 (46%)
		leucine-rich repeat	32..53	CDD:275380	7/20 (35%)
		leucine-rich repeat	76..97	CDD:275380	12/20 (60%)
		leucine-rich repeat	98..119	CDD:275380	10/20 (50%)
		leucine-rich repeat	120..141	CDD:275380	10/20 (50%)
		leucine-rich repeat	142..165	CDD:275380	12/22 (55%)
		leucine-rich repeat	166..190	CDD:275380	13/23 (57%)
		IQ	581..599	CDD:197470	6/19 (32%)
CEP97	NP_078824.2	leucine-rich repeat	17..37	CDD:275380	7/19 (37%)
		LRR 1	37..58		9/23 (39%)
		leucine-rich repeat	38..59	CDD:275380	8/23 (35%)
		PPP1R42	46..242	CDD:455733	92/195 (47%)
		LRR 2	59..80		9/20 (45%)
		leucine-rich repeat	60..81	CDD:275380	10/20 (50%)
		LRR 3	81..102		12/20 (60%)
		leucine-rich repeat	82..103	CDD:275380	12/20 (60%)
		LRR 4	103..124		11/20 (55%)
		leucine-rich repeat	104..125	CDD:275380	10/20 (50%)
		LRR 5	125..146		9/20 (45%)
		leucine-rich repeat	126..147	CDD:275380	10/20 (50%)
		LRR 6	147..168		10/20 (50%)
		leucine-rich repeat	148..171	CDD:275380	12/22 (55%)
		LRR 7	171..192		12/20 (60%)
		leucine-rich repeat	172..196	CDD:275380	13/23 (57%)
		LRR 8	196..205		3/8 (38%)
		CCP110-binding	300..750		105/521 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..529		5/30 (17%)
		IQCD	555..>575	CDD:467745	5/19 (26%)
		Interaction with MPHOSPH9. /evidence=ECO:0000269|PubMed:30375385	587..865		60/273 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	715..769		6/53 (11%)