DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Lrrc9

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_006516438.1	Gene:	Lrrc9 / 78257	MGIID:	1925507	Length:	1457	Species:	Mus musculus

Alignment Length:	596	Identity:	122/596 - (20%)
Similarity:	207/596 - (34%)	Gaps:	210/596 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YLKIETLSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLN 115
            |.||..|:|....|..:..:.:|..|:..:.|.|.:..:|||:.|::|..|.|:||.|..||.:.
Mouse   877 YSKITALNLDGQHLFEITNLEKLENLKWASFSNNNLSKMEGLESCVNLEELTLDGNCISKIEGIT 941

  Fly   116 TNVNLECLNLADNSIGSISDMSY--LRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSIND 178
            ....|..|::.:|.:..:...::  |.:|..|.|..||:|.|....|..  :|..|.::.|.|..
Mouse   942 RLTKLSRLSMNNNLLTGLEKHTFDNLLHLHSLSLENNRITSLSALQKTF--TLIELYISNNYIAV 1004

  Fly   179 LNEICTLSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWL 243
            ..||..|..|.||:.:.:..|  :.:.|.   .:||.||:.....||.:||..::..|:..|:.|
Mouse  1005 NQEIYNLKGLCNLVILDMYGN--IIIWNQ---ENYRFFVIFHLPELKALDGVSIETSETETAKDL 1064

  Fly   244 YSQGRGRQFRVGEQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSS 308
            :. ||.....:.|:||.:.::                               |:||.   |..||
Mouse  1065 FG-GRLTSDMIAERQGHSNFI-------------------------------QMQEL---NWTSS 1094

  Fly   309 ASTS----PSSHRKKPTSRIQSPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMS 369
            |..:    |..|.:                         |..:.|..||::.|.:|
Mouse  1095 AIRTVDLIPVDHFR-------------------------NVSNVNLQNNNLTSFSG--------- 1125

  Fly   370 ISLIENIKNDGEGFSLAGSGMSSSVTTKTYNSTESTPRNITPNPY--NDQTFISQTPSGGPLAAA 432
            :..:.|:|                |....||..||....:.|..:  :.|....:.||.|
Mouse  1126 LIYLPNVK----------------VLCLNYNHIESIMPRLKPQTHLSSRQLLYQKVPSSG----- 1169

  Fly   433 SKMVPVPETLMSPDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSS 497
                               ..|:.|          :|:|::.....|||.:
Mouse  1170 -------------------YGQQGT----------SKLNRDSVGSENLPPI-------------- 1191

  Fly   498 PRRMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLK 562
                        ||:.|.|..        |::...:..|:.:.:||.::.:..|..:....|.|
Mouse  1192 ------------MQSLEVLHL--------GYNGICNLVQLQLNRLRNLKFLFLQGNEISQVEGL- 1235

  Fly   563 QQVDNNLNCQDRLIE---------------------HVTES---------SAVTIQKMWRGYHTR 597
               ||.:..|:.:::                     |:.|:         |.|.::|::.||
Mouse  1236 ---DNLIVLQELVVDHNRIRAFNDTAFSKPSSLLMLHLEENRLRELSKLQSLVKLEKLFLGY--- 1294

  Fly   598 KKTNK--DIAE 606
               ||  ||.|
Mouse  1295 ---NKIQDITE 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		leucine-rich repeat	32..53	CDD:275380	1/1 (100%)
		LRR_RI	<49..189	CDD:238064	41/139 (29%)
		LRR_4	76..115	CDD:289563	15/38 (39%)
		leucine-rich repeat	76..97	CDD:275380	7/20 (35%)
		LRR_8	97..152	CDD:290566	16/56 (29%)
		LRR_4	97..137	CDD:289563	11/39 (28%)
		leucine-rich repeat	98..119	CDD:275380	8/20 (40%)
		leucine-rich repeat	120..141	CDD:275380	4/22 (18%)
		LRR_8	140..200	CDD:290566	18/59 (31%)
		leucine-rich repeat	142..165	CDD:275380	8/22 (36%)
		leucine-rich repeat	166..190	CDD:275380	8/23 (35%)
		IQ	581..599	CDD:197470	6/26 (23%)
Lrrc9	XP_006516438.1	internalin_A	<32..>264	CDD:380193
		leucine-rich repeat	47..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380
		leucine-rich repeat	100..121	CDD:275380
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..166	CDD:275380
		leucine-rich repeat	167..191	CDD:275380
		leucine-rich repeat	192..223	CDD:275380
		internalin_A	685..>959	CDD:380193	25/81 (31%)
		leucine-rich repeat	689..708	CDD:275380
		leucine-rich repeat	709..730	CDD:275380
		leucine-rich repeat	731..752	CDD:275380
		leucine-rich repeat	753..779	CDD:275380
		leucine-rich repeat	780..806	CDD:275380
		leucine-rich repeat	807..865	CDD:275380
		leucine-rich repeat	866..901	CDD:275380	7/23 (30%)
		internalin_A	879..>1262	CDD:380193	109/546 (20%)
		leucine-rich repeat	902..923	CDD:275380	7/20 (35%)
		leucine-rich repeat	924..945	CDD:275380	8/20 (40%)
		leucine-rich repeat	946..969	CDD:275380	4/22 (18%)
		leucine-rich repeat	992..1016	CDD:275380	8/23 (35%)
		leucine-rich repeat	1017..1044	CDD:275380	7/31 (23%)
		leucine-rich repeat	1132..1157	CDD:275380	7/40 (18%)
		leucine-rich repeat	1158..1194	CDD:275380	12/95 (13%)
		leucine-rich repeat	1195..1218	CDD:275380	5/30 (17%)
		leucine-rich repeat	1219..1240	CDD:275380	5/24 (21%)
		LRR_9	<1227..1366	CDD:373143	17/86 (20%)
		leucine-rich repeat	1241..1264	CDD:275380	1/22 (5%)
		leucine-rich repeat	1265..1286	CDD:275380	3/20 (15%)
		leucine-rich repeat	1287..1311	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910