DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cep97 and drc3

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_021327254.1	Gene:	drc3 / 777619	ZFINID:	ZDB-GENE-061103-349	Length:	514	Species:	Danio rerio

Alignment Length:	270	Identity:	72/270 - (26%)
Similarity:	117/270 - (43%)	Gaps:	66/270 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGDESGEEKHVLNLSKQKLKKVPKQDDA--------HSIRQLILDENELQKIDNIDSYLKIETL 57
            |||.:  ||..|::  :|.|::..::...        ..:.:|.||...:.||.::.|:..:..|
Zfish     2 MSGQQ--EEPGVID--EQMLQRAVEEQQTRYTEGIQLEEVLELRLDYRNILKIYHLWSFSSLTKL 62

  Fly    58 SLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLEC 122
            .|..|.:.|:.|:..|..|..|:||||.|..||||:..:.|:.|:|..|.|..||:|:|...|:.
Zfish    63 QLDNNAIERIEGLENLTNLTWLDLSFNKIEVIEGLQTLVKLQDLSLFNNRISVIENLDTLQRLQV 127

  Fly   123 LNLADNSIGSISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSH 187
            |:|.:|||..:.::.|||..:                     ||.||.||.|.|.:.:.
Zfish   128 LSLGNNSIAQLENVIYLRRFQ---------------------SLRTLNLAGNPICEEDR------ 165

  Fly   188 LSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVD--PIESLKAEWLYSQGRGR 250
                                     |:.||..:...|.|:|..::|  ..|:..|::.|:....|
Zfish   166 -------------------------YKTFVSAYLPELVYLDYRLLDEQTRETANAKYQYAIEEMR 205

  Fly   251 QFRVGEQQGL 260
            |..:.|||.:
Zfish   206 QNEMQEQQAM 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	3/27 (11%)
		leucine-rich repeat	32..53	CDD:275380	6/20 (30%)
		LRR_RI	<49..189	CDD:238064	44/139 (32%)
		LRR_4	76..115	CDD:289563	18/38 (47%)
		leucine-rich repeat	76..97	CDD:275380	11/20 (55%)
		LRR_8	97..152	CDD:290566	18/54 (33%)
		LRR_4	97..137	CDD:289563	15/39 (38%)
		leucine-rich repeat	98..119	CDD:275380	9/20 (45%)
		leucine-rich repeat	120..141	CDD:275380	8/20 (40%)
		LRR_8	140..200	CDD:290566	9/59 (15%)
		leucine-rich repeat	142..165	CDD:275380	0/22 (0%)
		leucine-rich repeat	166..190	CDD:275380	7/23 (30%)
		IQ	581..599	CDD:197470
drc3	XP_021327254.1	leucine-rich repeat	39..58	CDD:275380	6/18 (33%)
		leucine-rich repeat	59..80	CDD:275378	6/20 (30%)
		LRR_9	61..198	CDD:317038	52/188 (28%)
		leucine-rich repeat	81..102	CDD:275378	11/20 (55%)
		leucine-rich repeat	103..124	CDD:275378	9/20 (45%)
		leucine-rich repeat	125..149	CDD:275378	9/44 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910