DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cep97 and CFAP410

DIOPT Version :9

Sequence 1:NP_608811.2 Gene:Cep97 / 33610 FlyBaseID:FBgn0031575 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_001258370.1 Gene:CFAP410 / 755 HGNCID:1260 Length:375 Species:Homo sapiens


Alignment Length:534 Identity:100/534 - (18%)
Similarity:163/534 - (30%) Gaps:183/534 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLE 121
            :.|.|..:|.......||.:|:||              |        .|:.:..|.......:||
Human     1 MKLTRKMVLTRAKASELHSVRKLN--------------C--------WGSRLTDISICQEMPSLE 43

  Fly   122 CLNLADNSIGSISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLS 186
            .:.|:.|||.::..:|..:.|.||||..||                        |..|.|:..|.
Human    44 VITLSVNSISTLEPVSRCQRLSELYLRRNR------------------------IPSLAELFYLK 84

  Fly   187 HLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQ 251
            .|..|..:.:|:|||.    ......||..||.....|:.:|...|...|..:|     ...|.:
Human    85 GLPRLRVLWLAENPCC----GTSPHRYRMTVLRTLPRLQKLDNQAVTEEELSRA-----LSEGEE 140

  Fly   252 FRVG-EQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSPSS 315
            .... |::|.......:|            ..|..:.|.|:..:..|..|      ..|:.:...
Human   141 ITAAPEREGTGHGGPKLC------------CTLSSLSSAAETGRDPLDSE------EEATGAQDE 187

  Fly   316 HRKKPTSRIQSPRFS----------RLSGRQGSPESMVNSYHGNSSNNSIVSDNGST------NH 364
            ...||.||.|.|..|          |:||  |...:...|.|......::..::|::      .|
Human   188 RGLKPPSRGQFPSLSARDASSSHRGRVSG--GPLGAAAASAHCTHCTETVGREHGASQGPVGREH 250

  Fly   365 SLQMSISLIENIKNDGEGFSLAGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPL 429
            .....:          |.....||.:..||                    |..|.:::.|.|..|
Human   251 GASQGL----------EELCPRGSCVCGSV--------------------NAHTRVTRAPHGAVL 285

  Fly   430 AAASKMVPVPETLM-------SPDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQ 487
            |        |:.|:       .|..|.|                    ..|:.:...:|..| ||
Human   286 A--------PQPLLLSWSVECGPGPCWA--------------------EGNRSHVEEVPHTR-PQ 321

  Fly   488 LKRNQSPTSSPRRMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQK 552
                          |....:|:...|..|....:|.           .:::.|.|.|:::....:
Human   322 --------------AGLLCSDSPSVPNVLTAILLLL-----------RELDAEGLEAVQQTVGSR 361

  Fly   553 QQQMHQEQLKQQVD 566
            .|.:..|::::..:
Human   362 LQALRGEEVQEHAE 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cep97NP_608811.2 leucine-rich repeat 11..31 CDD:275380
leucine-rich repeat 32..53 CDD:275380
LRR_RI <49..189 CDD:238064 29/131 (22%)
LRR_4 76..115 CDD:289563 6/38 (16%)
leucine-rich repeat 76..97 CDD:275380 4/20 (20%)
LRR_8 97..152 CDD:290566 15/54 (28%)
LRR_4 97..137 CDD:289563 8/39 (21%)
leucine-rich repeat 98..119 CDD:275380 2/20 (10%)
leucine-rich repeat 120..141 CDD:275380 7/20 (35%)
LRR_8 140..200 CDD:290566 14/59 (24%)
leucine-rich repeat 142..165 CDD:275380 7/22 (32%)
leucine-rich repeat 166..190 CDD:275380 5/23 (22%)
IQ 581..599 CDD:197470
CFAP410NP_001258370.1 LRR_8 19..74 CDD:290566 20/100 (20%)
LRR_4 19..59 CDD:289563 12/61 (20%)
LRR 1 19..40 6/42 (14%)
LRR_4 40..80 CDD:289563 16/63 (25%)
LRR 2 41..62 7/20 (35%)
leucine-rich repeat 42..63 CDD:275382 7/20 (35%)
LRR 3 63..84 10/44 (23%)
leucine-rich repeat 64..87 CDD:275382 11/46 (24%)
leucine-rich repeat 89..117 CDD:275382 9/31 (29%)
LRRcap 104..122 CDD:197729 5/17 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..156 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.