DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Lrriq1

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_011241894.1	Gene:	Lrriq1 / 74978	MGIID:	1922228	Length:	1717	Species:	Mus musculus

Alignment Length:	816	Identity:	166/816 - (20%)
Similarity:	295/816 - (36%)	Gaps:	230/816 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESGEEKHVLNLSKQKLKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYG 69
            |:.|...|:.|:...|..:...|...:::.|.|..|::.:|..::|...::.|::..|||:...|
Mouse   871 ENLENLSVVLLNNNLLTSIHGFDGCTNLQSLELSHNKITRISGLESLKYLQELTVDHNQLISTKG 935

  Fly    70 VCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSIS 134
            :|....:..|:.|.|.:..|:|:..|..|:::.|:||.::....|..:|.|..|:|.||||.|:.
Mouse   936 LCEAPTIVYLDCSHNHLTGIDGIGNCGLLQIIKLQGNYLREPPSLRNHVLLRELHLDDNSISSVE 1000

  Fly   135 DMS--YLRNLKELYLHGNRLT------HLRQCDKCLPTSLETLTLAKNSINDL-NEICTLSHLSN 190
            .:|  :|..|:.|.:..|.|.      ||        .|||.|.::.|.::|| |.:|..:...:
Mouse  1001 GLSSCWLPLLQYLSISQNSLATIVPLFHL--------VSLEKLDVSNNCLSDLTNVMCWFNACYS 1057

  Fly   191 LLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVG 255
            |..:.:..||.:..||      :|..:|....:|:.::|   |.:.|      |:..|
Mouse  1058 LRELCLTGNPVLQEIN------WRDSILKTLPALRVLNG---DMLNS------YANDR------- 1100

  Fly   256 EQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSPSSHRKKP 320
                               :|....:.||.:|:..|:   ||||         .:..|..:..:.
Mouse  1101 -------------------IEEHYHQDLRCLLALCQY---QLQE---------FNLLPEKYITQK 1134

  Fly   321 TSRIQSPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSL 385
            ...:......|||  |...:.|..|:....::     :.|..|.:.:   |..|..||..: ||.
Mouse  1135 RDILTLHAVDRLS--QYYKDLMKLSHECRRAH-----EQGDVNTTER---SAAETNKNHPD-FSN 1188

  Fly   386 AGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPA 450
            ..|.:.:.......||.|:.....:|||. |..|...|.....|...::     |.||:
Mouse  1189 TDSALQNKTLHAQTNSCEADSPATSPNPL-DTVFRPSTSHCEELRGRNQ-----EKLMA------ 1241

  Fly   451 AVAQRVTVTALNPQLHK---TKINKNKDNK---LNLPRVRSPQLKRNQSPTSSPRRMAN------ 503
                           ||   ::|:...:::   :.:....||....:.:..|||.:.|.
Mouse  1242 ---------------HKSEQSRISSRSNSRASFIEMKMADSPMSNHHNAERSSPTKAAMVIQAQW 1291

  Fly   504 ---------KCSAD-NMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQ 558
                     .|||: :....|.||...:                             ..|...::
Mouse  1292 RSYIAHRQINCSAEMHPTTTEPLQDPLI-----------------------------NNQTTSNE 1327

  Fly   559 EQLKQQVDNNLNCQDRLIEHVTESSAVTIQKMWRGYHTRKK---TNKDIAERLQRRRTQEYIEQL 620
            |:.|..:|         |:...|.:|:.||.:|:|:..|||   ..|.|.:   ....:||.|..
Mouse  1328 ERRKTNMD---------IQEQREKAALHIQAVWKGFILRKKLATARKAIKD---EESGEEYEEID 1380

  Fly   621 GKDMLLTKAQLENERKIQQLQMQAINALWKKVSTMEVDPKGIPAAAEQGEDSNGGGSGHLSLDQN 685
            .:|....:..||.:              |..:.:.....:.:|.            |..|...:|
Mouse  1381 LEDFEFDEDALEKD--------------WPALDSTGFPSQTLPL------------SNQLPWPKN 1419

  Fly   686 SAAVVNDLAKRCTMLTDQVQMLQSSIGTIVNCLTMVCNLPQDAIKKQAEIIDCSSTQTDLIAVHT 750
            |..:.:|.    |..|..|:..|:          .:||..::.:..:...:..|.:::.::: .|
Mouse  1420 SRTLRHDE----TSPTIPVRPAQA----------WLCNEKENVMSSEYTQLSSSRSESGILS-WT 1469

  Fly   751 PQIEDLTNFPFTKTRPSTLALESKHEAALACPKIDE 786
            |.         :||....|....|.|      ||.|
Mouse  1470 PD---------SKTSRKNLLQSEKEE------KISE 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	4/19 (21%)
		leucine-rich repeat	32..53	CDD:275380	5/20 (25%)
		LRR_RI	<49..189	CDD:238064	44/148 (30%)
		LRR_4	76..115	CDD:289563	10/38 (26%)
		leucine-rich repeat	76..97	CDD:275380	6/20 (30%)
		LRR_8	97..152	CDD:290566	19/56 (34%)
		LRR_4	97..137	CDD:289563	14/39 (36%)
		leucine-rich repeat	98..119	CDD:275380	5/20 (25%)
		leucine-rich repeat	120..141	CDD:275380	10/22 (45%)
		LRR_8	140..200	CDD:290566	16/66 (24%)
		leucine-rich repeat	142..165	CDD:275380	6/28 (21%)
		leucine-rich repeat	166..190	CDD:275380	8/24 (33%)
		IQ	581..599	CDD:197470	7/17 (41%)
Lrriq1	XP_011241894.1	PTZ00121	<173..657	CDD:173412
		internalin_A	808..>1056	CDD:380193	54/192 (28%)
		leucine-rich repeat	833..854	CDD:275380
		leucine-rich repeat	855..875	CDD:275380	1/3 (33%)
		leucine-rich repeat	876..897	CDD:275380	4/20 (20%)
		leucine-rich repeat	898..919	CDD:275380	5/20 (25%)
		leucine-rich repeat	920..941	CDD:275380	6/20 (30%)
		leucine-rich repeat	942..963	CDD:275380	6/20 (30%)
		leucine-rich repeat	964..982	CDD:275380	5/17 (29%)
		leucine-rich repeat	986..1009	CDD:275380	10/22 (45%)
		leucine-rich repeat	1010..1031	CDD:275380	6/28 (21%)
		leucine-rich repeat	1058..1084	CDD:275380	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910