DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Drc3

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_083320.1	Gene:	Drc3 / 74665	MGIID:	1921915	Length:	523	Species:	Mus musculus

Alignment Length:	711	Identity:	129/711 - (18%)
Similarity:	235/711 - (33%)	Gaps:	258/711 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESGEEKHVLNLSKQK--LKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRM 67
            |.|.::....|:||:  |.|        .:..|.||...:.:|||:..:..::.|.|..|.:.|:
Mouse    24 EQGPQEEAGQLAKQEGILFK--------DVLSLQLDFQNILRIDNLWQFENLKKLQLNNNIIERI 80

  Fly    68 YGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGS 132
            .|:..|..|..|:||||.|.:||||...::|..|:|..|.|..::.|:..|.|:.|:|.:|.|.:
Mouse    81 EGLTNLIHLVWLDLSFNNIEAIEGLDTLVNLEDLSLSNNRISKVDSLDALVKLQVLSLGNNQISN 145

  Fly   133 ISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIA 197
            :.::.|||..                 .|    |.||:||.|.:::..|
Mouse   146 MMNIIYLRRF-----------------PC----LRTLSLAGNPVSEAEE---------------- 173

  Fly   198 DNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAK 262
                           |:.|:..:...|.|:|...||                .|.|   :....|
Mouse   174 ---------------YKMFIYAYLSDLVYLDFRRVD----------------EQMR---EMAKMK 204

  Fly   263 YLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSPSSHRKKPTSRIQSP 327
            :..|:..|      ...:.:|::.|.:.|..|.:|:|..|
Mouse   205 HQYSIDEL------KHREAQLQMKLEEEQAKQEKLEEHKM------------------------- 238

  Fly   328 RFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSLAGSGMSS 392
                         :.|...:|....:|:.|::...|     .:|.:..::...|.:.  ...:..
Mouse   239 -------------AFVEHLNGPFLFDSMYSEDVEGN-----KLSYLPGVRELLEAYK--DKFVII 283

  Fly   393 SVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAAVAQRVT 457
            .:....|...:...|.:..:.:|:                    .:.|.::.
Mouse   284 CLNIFEYGLNQQEKRKVELDTFNE--------------------CIQEAILE------------- 315

  Fly   458 VTALNPQLHKTKINK-NKDNKLNLPRVRSPQLKRNQSPTSSPRRMANKCSADNMQAPEKLQQSAV 521
                |....|.|:.| .:.:.|||..:      |.::..|:..:...:|
Mouse   316 ----NQDQGKLKVAKFEEKHLLNLNAI------REETDLSNIEKKLTEC---------------- 354

  Fly   522 LADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQQVDNNLNCQDRLIEHVTESSAVT 586
                    |:..||..|              ...:.:.||.:|::..:|..:|   ::|:...:.
Mouse   355 --------TESIGELFN--------------TLMILEMQLVEQLEETINIFER---NITDLVGLF 394

  Fly   587 IQKMWRGYHTRKKTNKDIAERLQRRRTQEYIEQLGKDMLLTKAQLENERKIQQLQMQAINALWKK 651
            |:.:                       |..|.|.        ..|||....:.|:: |||.| :|
Mouse   395 IENV-----------------------QSLIAQC--------RDLENHHHEKLLEI-AINTL-EK 426

  Fly   652 VSTMEVD---PKGIPAA-AEQGEDSNGGGSGH----LSLDQNSAAVVNDLAKRCTMLTDQV 704
            :...|:|   |..:.|. .::....|..|:.|    |.:|.....:|..:...|..|.|::
Mouse   427 ILKGEMDEDLPDDVRALFVDKDTIVNAVGASHDIHLLKIDNREDELVTGINSWCAHLVDKI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	5/21 (24%)
		leucine-rich repeat	32..53	CDD:275380	6/20 (30%)
		LRR_RI	<49..189	CDD:238064	40/139 (29%)
		LRR_4	76..115	CDD:289563	16/38 (42%)
		leucine-rich repeat	76..97	CDD:275380	11/20 (55%)
		LRR_8	97..152	CDD:290566	15/54 (28%)
		LRR_4	97..137	CDD:289563	12/39 (31%)
		leucine-rich repeat	98..119	CDD:275380	6/20 (30%)
		leucine-rich repeat	120..141	CDD:275380	7/20 (35%)
		LRR_8	140..200	CDD:290566	9/59 (15%)
		leucine-rich repeat	142..165	CDD:275380	1/22 (5%)
		leucine-rich repeat	166..190	CDD:275380	7/23 (30%)
		IQ	581..599	CDD:197470	1/17 (6%)
Drc3	NP_083320.1	LRR 1	44..65		6/20 (30%)
		leucine-rich repeat	47..66	CDD:275378	6/18 (33%)
		PPP1R42	53..200	CDD:411060	52/217 (24%)
		LRR 2	66..87		5/20 (25%)
		leucine-rich repeat	67..88	CDD:275378	6/20 (30%)
		LRR 3	88..109		11/20 (55%)
		leucine-rich repeat	89..110	CDD:275378	11/20 (55%)
		LRR 4	110..131		6/20 (30%)
		leucine-rich repeat	111..132	CDD:275378	6/20 (30%)
		LRR 5	132..153		6/20 (30%)
		leucine-rich repeat	133..157	CDD:275378	8/40 (20%)
		leucine-rich repeat	158..169	CDD:275378	6/10 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910