DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cep97 and Dnaaf1

DIOPT Version :10

Sequence 1:NP_608811.2 Gene:Cep97 / 33610 FlyBaseID:FBgn0031575 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_080924.1 Gene:Dnaaf1 / 68270 MGIID:1915520 Length:634 Species:Mus musculus


Alignment Length:646 Identity:138/646 - (21%)
Similarity:229/646 - (35%) Gaps:204/646 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SGDESGE----------EKHVLNLSKQKLKKVPKQDDAHSI-------RQLILDENELQKIDNID 49
            |||...|          |.....::||.|:|:.||   |.:       ..|.|......:|:|::
Mouse    59 SGDNGSEGFCTHSRDDREDRGPRMTKQFLQKLCKQ---HKLYVTPALNDTLYLHFKGFDRIENLE 120

  Fly    50 SYLKIETLSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHL 114
            .|..                      ||.|.|..|||..||.|:....||.|.|:.|.:..||:|
Mouse   121 EYTG----------------------LRCLWLECNGIQRIENLQAQSELRCLFLQVNLLHKIENL 163

  Fly   115 NTNVNLECLNLADNSIGSISDMSYLRNLKELYLHGNRL------THLRQCDKCLPTSLETLTLAK 173
            .....|:.|||::|.|.:|.::|.|..|..|.:..|||      .|||:|     ..|..|.|:.
Mouse   164 EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNRLETVADIEHLREC-----LRLCVLDLSH 223

  Fly   174 NSINDLNEICTLSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESL 238
            |:::|...:..|..:..|..:::..||....|.     :||..|......|.|:|...|.|.:..
Mouse   224 NALSDPEILSVLESMPCLRVLNLMGNPVTKHIP-----NYRRTVTVRLKHLTYLDDRPVFPKDRA 283

  Fly   239 KAE-WLYSQGRG---------RQFRVGEQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHH 293
            .|| |    .||         ||:...|.:.:...|.::..:..:|.|.:          ||   
Mouse   284 CAEAW----ARGGYAAEKEERRQWESREHKKITDSLEALAMIKRRAEERK----------KA--- 331

  Fly   294 QRQLQEEIMDNANSSASTSPSSHRKKPTSRIQ--------------------SPRFSR------L 332
             |...|..:.::..|..|||.:..|:|...||                    :|...:      :
Mouse   332 -RDRGETPLPDSEGSIPTSPEAEEKQPMGEIQKKMELFVEESFEAKDELFPETPGGEKELHVVVV 395

  Fly   333 SGRQGSPESMVNSYHGNS--------SNNSIVSDNGSTNHSLQ-MSISLIENI-------KNDGE 381
            :|...:|:...:..|..:        |.:.:.:.:|:....:: :::.:.|.:       ..|.|
Mouse   396 NGAVENPDLSGSLAHNQTPVVVTPEESTSPVAATDGARTEDIEAVAVEIKERLFIDDLPDLEDAE 460

  Fly   382 GFSLAGSGMSSSVTTKTYNSTESTPR-------NITPNPYNDQTFIS---QTPSG---------- 426
            |         :.|:.:........||       :...:|..|:..:|   .||:|          
Mouse   461 G---------TDVSVEDQIKETDIPRIQAISSLSDDSDPELDELSLSTSEATPTGATGALSHIFA 516

  Fly   427 ---GPLAAASKMVPVPETLMSPDVCP--------------AAVAQRVTVTALNPQLHKTKINKNK 474
               ||..||:    ||.|    |:|.              .|.|.|..:..||.:..:...|:  
Mouse   517 ISKGPSTAAT----VPFT----DICKPIATTDLESQGQDCGAAASRPLIQELNDEPAEEAANQ-- 571

  Fly   475 DNKLNLPRVRSPQLKRNQSPTSSPRRMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGE 535
                .||    ||...:....:.|        :::..:..:|..:.:|.|    ..:|:.|
Mouse   572 ----PLP----PQTCASDPALAHP--------SEDGDSDSQLPAATLLGD----GAEDEAE 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cep97NP_608811.2 leucine-rich repeat 11..31 CDD:275380 6/19 (32%)
PPP1R42 13..229 CDD:455733 63/228 (28%)
leucine-rich repeat 32..53 CDD:275380 5/27 (19%)
leucine-rich repeat 76..97 CDD:275380 10/20 (50%)
leucine-rich repeat 98..119 CDD:275380 8/20 (40%)
leucine-rich repeat 120..141 CDD:275380 9/20 (45%)
leucine-rich repeat 142..165 CDD:275380 9/28 (32%)
leucine-rich repeat 166..190 CDD:275380 6/23 (26%)
IQ 581..599 CDD:197470
Dnaaf1NP_080924.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..80 5/20 (25%)
LRR 1 101..123 4/21 (19%)
leucine-rich repeat 105..124 CDD:275380 5/18 (28%)
PPP1R42 106..290 CDD:455733 62/219 (28%)
LRR 2 124..145 10/42 (24%)
LRR 3 146..167 8/20 (40%)
leucine-rich repeat 147..168 CDD:275380 8/20 (40%)
LRR 4 168..189 8/20 (40%)
leucine-rich repeat 169..190 CDD:275380 9/20 (45%)
LRR 5 190..211 6/20 (30%)
leucine-rich repeat 191..215 CDD:275380 9/28 (32%)
LRR 6 215..236 5/20 (25%)
leucine-rich repeat 216..237 CDD:275380 6/20 (30%)
leucine-rich repeat 241..268 CDD:275380 7/31 (23%)
Borrelia_P83 <280..479 CDD:114011 36/225 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 326..358 10/45 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..505 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..634 13/76 (17%)
Blue background indicates that the domain is not in the aligned region.

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