DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and LRRC49

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001185946.1	Gene:	LRRC49 / 54839	HGNCID:	25965	Length:	691	Species:	Homo sapiens

Alignment Length:	684	Identity:	163/684 - (23%)
Similarity:	272/684 - (39%)	Gaps:	148/684 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SGEEKHV----LNLSKQKLKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLR 66
            |.|||.:    |:|.:|||...|..:....:|.|....|.:.:|.||.:..|:.:|.|..||:..
Human    89 SSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEE 153

  Fly    67 MYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIG 131
            :.|:..|.|||.|.|..|.|..|..|:....|.||:|.||.|..||::|....|..||||.|.:.
Human   154 ISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLS 218

  Fly   132 SISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISI 196
            .:.:::.|.:|.||.|..|::|.:|..|. || .|:.|.|:.|:|:..:.:..|:..|:|..|:.
Human   219 HVDNLNGLDSLTELNLRHNQITFVRDVDN-LP-CLQHLFLSFNNISSFDSVSCLADSSSLSDITF 281

  Fly   197 ADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLA 261
            ..||.     :.:.: |:..||...|.|:.:|...:...|...|..|..:...:: |...:|.|.
Human   282 DGNPI-----AQESW-YKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKK-RESHKQSLL 339

  Fly   262 KYLSSVCPLVGKALENENDRKLRLILSKAQHH---QRQLQEEIMDNANSSASTSPSSHRKKPTSR 323
            |                  .|.||.::.....   |:|....|..|.:...|.||     :...:
Human   340 K------------------EKKRLTINNVARQWDLQQQRVANIATNEDRKDSDSP-----QDPCQ 381

  Fly   324 IQSPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIEN--IKNDGEGFSLA 386
            |.....|......|..:|                   ..|::|| .:|:|:.  ::.||:..||.
Human   382 IDGSTLSAFPEETGPLDS-------------------GLNNALQ-GLSVIDTYLVEVDGDTLSLY 426

  Fly   387 GSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAA 451
            |||           :.||..||     ::.||             |..:..|..|.:..|
Human   427 GSG-----------ALESLDRN-----WSVQT-------------AGMITTVSFTFIEFD----- 457

  Fly   452 VAQRVTVTALNPQLHKTKINKN---KDNKLNLPRVRS----PQLKRNQSPTSSPR---------- 499
                 .:..:.|:| |.|...:   |..:.||..::.    .||:|....|..|:
Human   458 -----EIVQVLPKL-KIKFPNSLHLKFKETNLVMLQQFNALAQLRRIDQLTIDPQGNPVVNFTLW 516

  Fly   500 ------RMANKCSADNMQAPEKLQQSAVLADS-GGFSTDDDGEQINIEKLRAIRKMAAQKQQQMH 557
                  |::: .|...:...|..|...::|:. .|........::...:|.:|...|.:||.:..
Human   517 KYYVLFRLSH-FSMQKINGTEVTQNDMIMAERLFGILAHVASSELPQYRLISILGDARKKQFRYL 580

  Fly   558 QEQLKQQ---VDNNLNCQDRLIEHVTESSAVTIQKMWRGYHTRKKTNKDIAERLQRRR-TQEYIE 618
            .|...::   ::...|...||:...|..:.:       .|.||...|:.:.|..:::: .:.|||
Human   581 LESKGKKPGIINEENNDSKRLVGENTNRATL-------NYTTRDFYNEKLEEIKEKKKFCKTYIE 638

  Fly   619 QLGKDMLLTKAQLENERKIQQLQMQAINALWKKV 652
            .|.|:  .|:..::||         |:..||.::
Human   639 DLVKE--ATEINMKNE---------ALQKLWPQM 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	6/23 (26%)
		leucine-rich repeat	32..53	CDD:275380	6/20 (30%)
		LRR_RI	<49..189	CDD:238064	49/139 (35%)
		LRR_4	76..115	CDD:289563	17/38 (45%)
		leucine-rich repeat	76..97	CDD:275380	8/20 (40%)
		LRR_8	97..152	CDD:290566	22/54 (41%)
		LRR_4	97..137	CDD:289563	16/39 (41%)
		leucine-rich repeat	98..119	CDD:275380	10/20 (50%)
		leucine-rich repeat	120..141	CDD:275380	7/20 (35%)
		LRR_8	140..200	CDD:290566	19/59 (32%)
		leucine-rich repeat	142..165	CDD:275380	10/22 (45%)
		leucine-rich repeat	166..190	CDD:275380	6/23 (26%)
		IQ	581..599	CDD:197470	3/17 (18%)
LRRC49	NP_001185946.1	LRR_8	118..173	CDD:290566	19/54 (35%)
		LRR_4	118..158	CDD:289563	12/39 (31%)
		LRR 1	118..139		6/20 (30%)
		leucine-rich repeat	119..140	CDD:275380	6/20 (30%)
		LRR_4	139..181	CDD:289563	16/41 (39%)
		LRR 2	140..161		6/20 (30%)
		leucine-rich repeat	141..162	CDD:275380	6/20 (30%)
		LRR 3	162..183		9/20 (45%)
		LRR_4	163..203	CDD:289563	17/39 (44%)
		leucine-rich repeat	163..184	CDD:275380	8/20 (40%)
		LRR 4	184..205		10/20 (50%)
		leucine-rich repeat	185..206	CDD:275380	10/20 (50%)
		LRR_4	205..247	CDD:289563	14/41 (34%)
		LRR_8	206..261	CDD:290566	21/56 (38%)
		LRR 5	206..227		6/20 (30%)
		leucine-rich repeat	207..228	CDD:275380	7/20 (35%)
		LRR_4	228..268	CDD:289563	15/41 (37%)
		LRR 6	228..249		8/21 (38%)
		leucine-rich repeat	229..250	CDD:275380	10/22 (45%)
		LRR 7	250..271		5/20 (25%)
		leucine-rich repeat	251..275	CDD:275380	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..393		6/32 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910