DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cep97 and Lrrc6

DIOPT Version :9

Sequence 1:NP_608811.2 Gene:Cep97 / 33610 FlyBaseID:FBgn0031575 Length:806 Species:Drosophila melanogaster
Sequence 2:NP_062330.1 Gene:Lrrc6 / 54562 MGIID:1859553 Length:473 Species:Mus musculus


Alignment Length:517 Identity:113/517 - (21%)
Similarity:192/517 - (37%) Gaps:139/517 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 CRLHCLRELNLSFNGILSIEGL-KECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSIS 134
            |.:..|.||:|....|..:|.: |.|..|::|.|:.|.|..||:::....||.||||.|:|    
Mouse    18 CVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNI---- 78

  Fly   135 DMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADN 199
                           .|:.:|..|:     .|..|.|..|.|.:|:.:.||:|..:|..:.:..|
Mouse    79 ---------------ERIENLEGCE-----WLTKLDLTVNFIGELSSVKTLTHNIHLKELFLMGN 123

  Fly   200 PCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKA--------------EWLYSQGRGR 250
            ||.    ..||  ||.||:.....||::||..::..|.::|              |..|...|.:
Mouse   124 PCA----DFDG--YRQFVVVTLQQLKWLDGKEIERSERIQALQNYTSVEQQIREQEKAYCLRRAK 182

  Fly   251 QFRVG------EQQGLAKYLSS-------------VCPLVGKALENENDRKLRLILSKAQHHQRQ 296
            :....      |.:...|..||             .||   .|.||::..::.  .::.:.|..:
Mouse   183 EKEEAQRKLEEENESEDKKKSSTGFDGHWYTDIHTACP---SATENQDYPQVP--ETQEEQHNTK 242

  Fly   297 LQEEIMDNA---NSSASTSPSS------HRKKPTSRIQSPRFSRLSGRQGSPESMVN-------- 344
            ..::|.|:.   |..:..:|.|      |.:|  .|....:.|....:...|.:::.        
Mouse   243 ESDDIEDDLAFWNKPSLFTPESRLETLRHMEK--QRKAQDKLSEKKKKAKPPRTLITEDGKVLNV 305

  Fly   345 -------SYHGNSSNNSIVSDNGSTNHSLQMSISLIE--------NIKNDGEGFSLAGSGMSSSV 394
                   |...:..:|.|:.|.....:   |..||||        .:...|:.|.||        
Mouse   306 NEAKLDFSLKDDEKHNQIILDLAVYRY---MDTSLIEVDVQPTYVRVMVKGKPFQLA-------- 359

  Fly   395 TTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAAVAQRVTVT 459
                 .|||..|         |::...::.:.|.|...  |..|.|.:......|.:|  :.|.|
Mouse   360 -----LSTEVQP---------DRSSAKRSQTTGHLLIC--MPKVGEMITGGQRTPTSV--KTTST 406

  Fly   460 A----LNP---QLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRMANKCSADNMQAPE 514
            :    .||   |:.:.:::.:|.:..::..:...:..|.:...|.||...::...|....||
Mouse   407 SSREQTNPRKKQIERLEVDPSKHSCPDVSTIVQEKRHRPKRMESQPRDEPSEEDPDFEDNPE 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cep97NP_608811.2 leucine-rich repeat 11..31 CDD:275380
leucine-rich repeat 32..53 CDD:275380
LRR_RI <49..189 CDD:238064 36/118 (31%)
LRR_4 76..115 CDD:289563 15/39 (38%)
leucine-rich repeat 76..97 CDD:275380 8/21 (38%)
LRR_8 97..152 CDD:290566 15/54 (28%)
LRR_4 97..137 CDD:289563 15/39 (38%)
leucine-rich repeat 98..119 CDD:275380 7/20 (35%)
leucine-rich repeat 120..141 CDD:275380 8/20 (40%)
LRR_8 140..200 CDD:290566 13/59 (22%)
leucine-rich repeat 142..165 CDD:275380 3/22 (14%)
leucine-rich repeat 166..190 CDD:275380 9/23 (39%)
IQ 581..599 CDD:197470
Lrrc6NP_062330.1 LRR_4 22..64 CDD:289563 15/41 (37%)
LRR 1 22..43 7/20 (35%)
leucine-rich repeat 23..45 CDD:275378 8/21 (38%)
LRR 2 45..66 7/20 (35%)
LRR_8 46..98 CDD:290566 21/75 (28%)
LRR_4 46..86 CDD:289563 17/58 (29%)
leucine-rich repeat 46..67 CDD:275378 7/20 (35%)
LRR 3 67..88 10/39 (26%)
leucine-rich repeat 68..89 CDD:275378 11/44 (25%)
LRR 4 89..110 7/20 (35%)
leucine-rich repeat 90..114 CDD:275378 9/23 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 188..244 10/60 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 273..292 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 387..473 17/84 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R8601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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