DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Lrriq3

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001019478.1	Gene:	Lrriq3 / 499732	RGDID:	1591943	Length:	633	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	129/620 - (20%)
Similarity:	223/620 - (35%)	Gaps:	148/620 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LSFNG--ILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSISDMSY---LR 140
            :.:||  :.|:|.|:.||.|||.....|.:..|:.|.....|..|:|..|.|.::.|.::   |:
  Rat    33 VKYNGLHLKSMENLQSCISLRVCIFSNNFVTDIQPLQGCKKLIKLDLHGNQIKTLPDRTFWNGLK 97

  Fly   141 NLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADNPCVTMI 205
            |||.||||.|....|:                        .||.||...||:.:::.|.|    :
  Rat    98 NLKLLYLHDNGFAKLK------------------------NICVLSGCVNLVGLTMFDCP----V 134

  Fly   206 NSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYLSSVC-- 268
            :...|  ||..::|....||.:|..|:.. |.:...|...:    :|:...|    ....::|
  Rat   135 SLKKG--YRHVLVNSIWPLKALDHHVISD-EEIIQNWHLPE----RFKTFSQ----SLFFNICPA 188

  Fly   269 PLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSPSSHRKKPTSRIQ-------- 325
            |:.|...|:|        :...:|...::.|.:..|:              |...||
  Rat   189 PIKGTTYEDE--------IKNIKHIISRINEILAHNS--------------PVLIIQRWIRGFIV 231

  Fly   326 ----SPRFSRLSGRQGSPESMVNSYH------GNSSNNSIVSD----------NGSTNHSLQMSI 370
                ||.|:    |:...:.|:....      |.::.:..:.|          .|...|..||..
  Rat   232 RKHLSPYFT----RKRHHDRMIRVLETKLICIGRNNEDKFLEDIFLIKPESNIKGKVAHWKQMRY 292

  Fly   371 SLIENIKNDGEGFSLAGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKM 435
            | .::.|...| :....|.:|..:.||........||:......|:....|:..........|.|
  Rat   293 S-PDDFKYSTE-YRKHISCLSYELKTKDIAGNSKQPRHHIQKGQNEMKSDSEDEEVDTKFRISAM 355

  Fly   436 VPVPETLMSPDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVR-SPQLKRNQSPTSSPR 499
             .:|       :||:...:      ....|.:.|.:...:....||..| .||:||........|
  Rat   356 -KIP-------LCPSRSLK------YRAMLKEIKWDYFPEYLQPLPATRQKPQVKRETHEELKER 406

  Fly   500 RMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQQ 564
            |        |..|.::......|     |:..|.......::....||.||....|:.||:.:..
  Rat   407 R--------NFLASQRAGMDLHL-----FNDIDKYYSEQRQQEEEARKFAATAAAQVAQERARLN 458

  Fly   565 VDNNLNCQDRLIEHVTESSAVTIQK----MWRGYHTRKKTNKDIAERLQRRRT----QEYIEQLG 621
            ...||..:..:...:.:....||||    :|       |...:..|:::.|::    ::.:....
  Rat   459 TSENLRKKISMARKLMQKDNETIQKGLRHIW-------KERLNYLEKVRERKSMFLAEKKLNAAD 516

  Fly   622 KDMLLTKAQLENERKIQQLQMQAINALWKKVSTME 656
            :.::|:   |.|||.|....:..::.|.:.:|.|:
  Rat   517 QSLVLS---LNNERSILLRGIIQVDKLKRDLSEMK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		leucine-rich repeat	32..53	CDD:275380
		LRR_RI	<49..189	CDD:238064	33/112 (29%)
		LRR_4	76..115	CDD:289563	12/35 (34%)
		leucine-rich repeat	76..97	CDD:275380	6/17 (35%)
		LRR_8	97..152	CDD:290566	21/57 (37%)
		LRR_4	97..137	CDD:289563	12/39 (31%)
		leucine-rich repeat	98..119	CDD:275380	6/20 (30%)
		leucine-rich repeat	120..141	CDD:275380	7/23 (30%)
		LRR_8	140..200	CDD:290566	16/59 (27%)
		leucine-rich repeat	142..165	CDD:275380	8/22 (36%)
		leucine-rich repeat	166..190	CDD:275380	4/23 (17%)
		IQ	581..599	CDD:197470	5/21 (24%)
Lrriq3	NP_001019478.1	PPP1R42	36..>128	CDD:411060	35/115 (30%)
		LRR 1	51..72		6/20 (30%)
		leucine-rich repeat	52..73	CDD:275378	6/20 (30%)
		LRR 2	73..94		6/20 (30%)
		leucine-rich repeat	74..98	CDD:275378	7/23 (30%)
		LRR 3	98..119		11/44 (25%)
		leucine-rich repeat	99..115	CDD:275378	8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..343		4/20 (20%)
		DUF5401	<388..>586	CDD:375164	38/184 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910