DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and cep97

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_009303333.2	Gene:	cep97 / 386640	ZFINID:	ZDB-GENE-031030-11	Length:	631	Species:	Danio rerio

Alignment Length:	730	Identity:	214/730 - (29%)
Similarity:	324/730 - (44%)	Gaps:	181/730 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VLNLSKQKLKKVPKQ---DDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYGVCRL 73
            ||:||.:.|:::..|   .|:|: ..||||:|:|.|:::::....::.||:|.|:|:||..||||
Zfish    38 VLDLSARGLQRLEPQLFRPDSHT-HTLILDQNQLMKLEHLEHNPDLQQLSVACNRLVRMMNVCRL 101

  Fly    74 HCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSISDMSY 138
            ..||.|:|..|.|..||||||...|..|||.|||||.:|.|:..|:|:.|:|:||:|..|.|:|.
Zfish   102 TQLRVLDLQNNSIGCIEGLKELQQLERLNLAGNNIKVMEQLHHCVSLQHLDLSDNNISQIGDVSR 166

  Fly   139 LRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADNPCVT 203
            |..|:.|.||||.:|.||.....||..|..|:||:|.|.||.|:|.|:.:..|..:|:..||||:
Zfish   167 LSALQTLLLHGNIITTLRSAPAHLPAHLRVLSLAENEIRDLTEVCYLAPVRGLQQLSLLSNPCVS 231

  Fly   204 MINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYLSSVC 268
            .::|. ..||||:||:||:.|:.:||..|...|.|||||||||||||.||.||...|.:|||..|
Zfish   232 CVSSA-VCDYRPYVLSWCLGLELLDGVAVTQKEGLKAEWLYSQGRGRVFRPGEHTQLLQYLSRTC 295

  Fly   269 PLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSPSSHRKKPTSRIQSPRFSRLS 333
            |...:....| |.||..||:|.:|||.|||.               :|.:.|:      |.:.|.
Zfish   296 PAAARQPPAE-DAKLEKILNKQRHHQNQLQH---------------THHQTPS------RPTHLD 338

  Fly   334 GRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEG-FSLAGSGMSSSVTTK 397
                     |...|.::.:                     |:.:::|:. .:.|...:..:|...
Zfish   339 ---------VQQLHQSTPD---------------------EDEEDEGDDVIAQAAVYVEPAVRVN 373

  Fly   398 TYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAAVAQRVTVTALN 462
            .:..:.|.|....|            ||..|.|.|:      :.|:..|:
Zfish   374 AWMDSVSPPLAAPP------------PSAPPPAVAA------DGLLLQDL--------------- 405

  Fly   463 PQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRMANKCSADNMQAPEKLQQSAVLADSGG 527
                                             .:|..:|::.:|....||          |||.
Zfish   406 ---------------------------------EAPGPLASESAAPPASAP----------DSGE 427

  Fly   528 FSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQQVDNNLNCQDRLIEHVTESSAVTIQKMWR 592
            ...:|.               .|......|:...::.|...::.:.:..|  .:.:||.||..||
Zfish   428 EEFEDS---------------LAPPTSTQHRAPGEEPVCGGVSSEHQQCE--PQDAAVRIQSWWR 475

  Fly   593 GYHTRKKTNKDIAER--LQRRRTQEYIEQLGKDMLLTKAQLENERKIQQLQMQAINALWKKVSTM 655
            |..||::..:..|.|  ::.||.|::|..|...:...:.|.|.||..:::|.:|:..|||::..:
Zfish   476 GQWTRQRHPQARAVRAEIRMRRMQDHIIHLSTQLDRVRRQQEEERLQRRVQEEAVKVLWKQLQVL 540

  Fly   656 -----EVDPK------------GIPA--AAEQGEDSNGGGSGHLSLD--------QNSAAVVNDL 693
                 .||.:            ..||  ||....||:.....|..|.        .||:|...|
Zfish   541 LQWQASVDQRLNTTHTPALNKTHTPADSAAHTPADSSTDTHTHADLSVPECGSPCVNSSAASGD- 604

  Fly   694 AKRCTMLTDQVQMLQ 708
            |:.|::|...:..:|
Zfish   605 AQNCSLLEQYLSSVQ 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	7/21 (33%)
		leucine-rich repeat	32..53	CDD:275380	7/20 (35%)
		LRR_RI	<49..189	CDD:238064	67/139 (48%)
		LRR_4	76..115	CDD:289563	22/38 (58%)
		leucine-rich repeat	76..97	CDD:275380	12/20 (60%)
		LRR_8	97..152	CDD:290566	28/54 (52%)
		LRR_4	97..137	CDD:289563	20/39 (51%)
		leucine-rich repeat	98..119	CDD:275380	11/20 (55%)
		leucine-rich repeat	120..141	CDD:275380	10/20 (50%)
		LRR_8	140..200	CDD:290566	24/59 (41%)
		leucine-rich repeat	142..165	CDD:275380	11/22 (50%)
		leucine-rich repeat	166..190	CDD:275380	11/23 (48%)
		IQ	581..599	CDD:197470	9/17 (53%)
cep97	XP_009303333.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595514
Domainoid	1	1.000	60	1.000	Domainoid score	I10536
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1264004at2759
OrthoFinder	1	1.000	-	-		FOG0007484
OrthoInspector	1	1.000	-	-		oto41037
orthoMCL	1	0.900	-	-		OOG6_107805
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.800