Protein Alignment Cep97 and LRRC9

DIOPT Version :10

• Sequence 1: NP_608811.2
• Gene: Cep97 / 33610
• FlyBaseID: FBgn0031575
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001342201.1
• Gene: LRRC9 / 341883
• HGNCID: 19848
• Length: 1494
• Species: Homo sapiens
• Alignment Length: 769
• Identity: 159/769 - (20%)
• Similarity: 272/769 - (35%)
• Gaps: 243/769 - (31%)

  Fly    51 YLKIETLSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLN 115
            ||||..|:|....|..:..:.:|..|:..:.|.|.:..:|||:.||:|..|.|:||.|..||.::
Human   886 YLKITALNLDGQHLFEITNLEKLENLKWASFSNNNLTKMEGLESCINLEELTLDGNCISKIEGIS 950

  Fly   116 TNVNLECLNLADNSIGSISDMSY--LRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSIND 178
            ....|..|::.:|.:....:.::  :.:|..|.|..||:|.|....|..  :|..|.::.|.|..
Human   951 KMTKLTRLSINNNLLTGWEEHTFDNMLHLHSLSLENNRITSLSGLQKSF--TLVELYISNNYIAV 1013

  Fly   179 LNEICTLSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWL 243
            ..|:..|..|.||:.:.:..|  :.:.|.   .:||.||:.....||.:||..::|.|:..|:.|
Human  1014 NQEMHNLKGLCNLVILDMCGN--IIIWNQ---ENYRLFVIFHLPELKALDGIPIEPSETDSAKDL 1073

  Fly   244 YSQGRGRQFRVGEQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSS 308
            :. ||.....:.|:||.:.:                               :|:||  ::..:||
Human  1074 FG-GRLTSDMIAERQGHSNF-------------------------------KQMQE--LNWTSSS 1104

  Fly   309 ASTSPSSHRKKPTSRIQSPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLI 373
            ..|         ...|...:|.             |..:.|..||.:.|.:|         :..:
Human  1105 IRT---------VDLIPVDQFR-------------NVCNVNLQNNHLTSFSG---------LIYL 1138

  Fly   374 ENIKNDGEGFSLAGSGMSSSVTTKTYNSTESTPRNITPNPY--NDQTFISQTPSGGPLAAASKMV 436
            .|:|                |....||..||....:.|..:  :.|....:.||.|
Human  1139 PNVK----------------VLCLNYNHIESIMPRLKPQTHLTSRQLLYQKVPSSG--------- 1178

  Fly   437 PVPETLMSPDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRM 501
                                     ..|...:|.|::..:..|||.:
Human  1179 -------------------------YGQQGISKTNRDIMSSENLPPI------------------ 1200

  Fly   502 ANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQQVD 566
                    |.:.|.|..        |::...:..|:.:.:||.::.:..|..:....|.|    |
Human  1201 --------MHSLEVLHL--------GYNGICNLIQLQLNRLRNLKFLFLQGNEISQVEGL----D 1245

  Fly   567 NNLNCQDRLIEHVTESSAVTIQKMWRGYHTR--KKTNKDIAERLQRRRTQEYIEQLGKDMLLTKA 629
            |.:..|:.:::|          ...|.::..  .|.:..:|..|:..|.:|    |||
Human  1246 NLVVLQELVVDH----------NRIRSFNDSAFAKPSSLLALHLEENRLRE----LGK------- 1289

  Fly   630 QLENERKIQQL-----QMQAINALWK--KVSTM-EVDPKGIPAAAEQGEDSNGGGSGHLSLDQNS 686
             |::..|:::|     ::|.|..|.|  .:||: |:...|.|
Human  1290 -LQSLVKLEKLFLGYNKIQDITELEKLDVISTLRELTVYGNP----------------------- 1330

  Fly   687 AAVVNDLAKRCTMLTDQVQMLQSSIGTIVNCLTMVCNLPQDAIKKQAEIIDCSSTQTDLIAV-HT 750
              :...:..| .||..::..||...|:.||        ..|..|.:..:.:..:.:..||.| |:
Human  1331 --ICRKMLHR-HMLIFRLPNLQMLDGSPVN--------SDDRAKAEFHLAELQAKKNSLIPVTHS 1384

  Fly   751 PQIEDLTNFPFTKTRP---STLALESKHEAALACPKIDELNDVDLKETQEDSEN 801
            |.  |..:|...||.|   :.:.|.|.....|.       :||.|....||.:|
Human  1385 PM--DGRSFGQVKTPPIEITNVLLPSGFSHYLG-------SDVTLTPEVEDKKN 1429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		PPP1R42	13..229	CDD:455733	52/179 (29%)
		leucine-rich repeat	32..53	CDD:275380	1/1 (100%)
		leucine-rich repeat	76..97	CDD:275380	7/20 (35%)
		leucine-rich repeat	98..119	CDD:275380	8/20 (40%)
		leucine-rich repeat	120..141	CDD:275380	3/22 (14%)
		leucine-rich repeat	142..165	CDD:275380	8/22 (36%)
		leucine-rich repeat	166..190	CDD:275380	7/23 (30%)
		IQ	581..599	CDD:197470	1/19 (5%)
LRRC9	NP_001342201.1	leucine-rich repeat	37..51	CDD:275380
		PPP1R42	55..236	CDD:455733
		leucine-rich repeat	56..77	CDD:275380
		leucine-rich repeat	78..99	CDD:275380
		leucine-rich repeat	100..121	CDD:275380
		leucine-rich repeat	122..143	CDD:275380
		leucine-rich repeat	144..166	CDD:275380
		leucine-rich repeat	192..223	CDD:275381
		LRR	631..1016	CDD:443914	39/131 (30%)
		leucine-rich repeat	698..717	CDD:275380
		leucine-rich repeat	718..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	762..788	CDD:275380
		leucine-rich repeat	789..846	CDD:275380
		leucine-rich repeat	847..910	CDD:275380	8/23 (35%)
		PPP1R42	878..1066	CDD:455733	55/186 (30%)
		leucine-rich repeat	911..932	CDD:275380	7/20 (35%)
		leucine-rich repeat	933..954	CDD:275380	8/20 (40%)
		leucine-rich repeat	955..978	CDD:275380	3/22 (14%)
		leucine-rich repeat	1026..1094	CDD:275380	20/104 (19%)
		PPP1R42	1116..1361	CDD:455733	68/410 (17%)
		leucine-rich repeat	1141..1166	CDD:275380	7/40 (18%)
		leucine-rich repeat	1167..1203	CDD:275380	11/95 (12%)
		leucine-rich repeat	1204..1227	CDD:275380	5/30 (17%)
		leucine-rich repeat	1228..1249	CDD:275380	5/24 (21%)
		leucine-rich repeat	1250..1273	CDD:275380	4/32 (13%)
		leucine-rich repeat	1274..1295	CDD:275380	8/32 (25%)
		leucine-rich repeat	1296..1320	CDD:275380	5/23 (22%)