DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and dtr

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_724335.2	Gene:	dtr / 318856	FlyBaseID:	FBgn0023090	Length:	1483	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	183/856 - (21%)
Similarity:	321/856 - (37%)	Gaps:	204/856 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KQKLKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYGVCRLHCLRELNL 81
            |.||.:.|:.:|.     |.|.....|.|::::.|.:::.|.|..|.:..:.|:.:|..|:.|.|
  Fly    26 KDKLYQTPRLNDV-----LYLHYQGFQCIESLEEYTELKCLWLECNAISEIQGLEKLSKLKCLFL 85

  Fly    82 SFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNV--NLECLNLADNSIGSISDMSYLRNLKE 144
            ..|.|..||.|..|..|..|||..|:|:.|:::.|||  .|..|.::.|         ||::
  Fly    86 QNNLITKIENLDPCRELDTLNLSSNHIRKIQNIGTNVLPVLNTLTISSN---------YLKD--- 138

  Fly   145 LYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADNPCVTMINSLD 209
                ...|:.|.||     .:|..|.|:.|.|:|:..:.....:.||..:.:..||.|:.:.
  Fly   139 ----SESLSDLIQC-----KTLSVLDLSNNRIDDILIVKIFEQMLNLKVLVLQGNPVVSRLP--- 191

  Fly   210 GFDYRPFVLNWCMSLKYIDGFVVDPIESLKAE-WLYSQGRGRQFRVGEQQGLAKYLSSVCPLVGK 273
              .||..::..|..|.|:|...|.|.:...|| |             ::.|..          |:
  Fly   192 --QYRKTLILACKELTYLDSRPVFPRDRACAEAW-------------KRDGYE----------GE 231

  Fly   274 ALENE-----NDRKLR-----LILSKAQHHQRQLQEEIMDNANSSASTSPSSHRKKPT--SRIQS 326
            ..||.     ..||.|     .|..:..|.....|:.::.:::|...|...:.|||..  :....
  Fly   232 RKENNRWNRAERRKTRESINCTIRMRNSHRPPDQQDPLLRSSDSEDDTCAETARKKVALENGCVD 296

  Fly   327 PRFSRLSGRQGSPESMVNS------YHGNSSNNSIVSDNGSTNHSL--------QMSISLIENIK 377
            ..:..:||.|...|...||      ..|.||.:.::::..|...:|        :..:|.:::..
  Fly   297 DLWEEVSGEQPISEDGTNSSSSLEDNDGTSSQDDLIAEKLSNRRTLEGRPTVLYETEVSNVKSAN 361

  Fly   378 NDGEGFSLAGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETL 442
            ||...|. .|.|.:|.:..:....|:....| .|:..||::.::.| |.||:...:......|..
  Fly   362 NDINIFE-EGVGKASQIIIEDKPVTKIKLIN-EPSCMNDKSAMNCT-SMGPVVKENDFDEDAEIK 423

  Fly   443 MSPDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRMANKCSA 507
            ...|:.|.                :..|..|:|  :|.....|.:||::...|.:..|...:|..
  Fly   424 NVDDMVPC----------------QNLIKSNED--INSEFGFSSKLKQDFDQTCTALRNDAECKE 470

  Fly   508 DNMQAPEKLQQSAVLADSGG-FSTDDD--GEQINIEKLRAI-------------RKMAAQKQQQM 556
            .:.:...|..:|....:... |:.:||  .|.:::......             .||.:..::.:
  Fly   471 FDEELTIKESESKPFNEMYDIFAAEDDKLNETLDLNLNETTCPHHVHDNFFSEQNKMPSFYEEDI 535

  Fly   557 HQEQLKQQVDNNLNCQDRLIEHVTESSAVTIQKMWRGYHTRKKTNKDIAERLQRRRTQEYIEQLG 621
            ....|.:..:..|..:|.:||:  |..|..:.:|.|      :..:|:||  .|:.||..|....
  Fly   536 MINLLPKTKEKTLLEKDSIIEN--EKCAHDLDEMGR------QMEEDLAE--LRQSTQNLIGISI 590

  Fly   622 KDMLLTKAQLENERKIQQ-------LQMQAINALWKKVSTME-------VDPKGIPAAAEQGEDS 672
            .:...|.::.:.|..|.|       |:.|..:...|.:.|.|       :..:.|..:.|..:|.
  Fly   591 DETARTDSETDEEDLIAQQDPYSPLLKQQFKDRRMKIMLTEETKAQEESLSDRNIALSNESDQDD 655

  Fly   673 NGGGSGHLSLDQNSAAVVND----LAKR-----CTMLTDQVQMLQSSIGTIVNCLTMVCNLPQDA 728
                    ..||..|.:::|    :.||     |..|        ||:.....||..: .||::.
  Fly   656 --------KQDQLFAKILDDATENIPKRIFGTGCDAL--------SSVWPQEECLLQL-TLPENK 703

  Fly   729 IKKQAEIIDCSSTQTDLIAVHTPQIEDLTNFPFTKTRPSTLALESKHEAALACPKIDELNDVDLK 793
                                .:|..||    .|.|:..::.:.|..:|   .|.::|:
  Fly   704 --------------------ESPAQED----TFKKSITNSTSFEKANE---ICVRMDQ------- 734

  Fly   794 ETQEDSENLDK 804
            :..|:.|.|.|
  Fly   735 KMAEEEEALGK 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	5/13 (38%)
		leucine-rich repeat	32..53	CDD:275380	5/20 (25%)
		LRR_RI	<49..189	CDD:238064	40/141 (28%)
		LRR_4	76..115	CDD:289563	16/38 (42%)
		leucine-rich repeat	76..97	CDD:275380	9/20 (45%)
		LRR_8	97..152	CDD:290566	15/56 (27%)
		LRR_4	97..137	CDD:289563	13/41 (32%)
		leucine-rich repeat	98..119	CDD:275380	10/22 (45%)
		leucine-rich repeat	120..141	CDD:275380	5/20 (25%)
		LRR_8	140..200	CDD:290566	12/59 (20%)
		leucine-rich repeat	142..165	CDD:275380	4/22 (18%)
		leucine-rich repeat	166..190	CDD:275380	6/23 (26%)
		IQ	581..599	CDD:197470	4/17 (24%)
dtr	NP_724335.2	leucine-rich repeat	38..57	CDD:275380	5/23 (22%)
		LRR_8	56..112	CDD:290566	19/55 (35%)
		LRR_4	56..98	CDD:289563	13/41 (32%)
		LRR_RI	58..>184	CDD:238064	41/146 (28%)
		leucine-rich repeat	58..79	CDD:275380	5/20 (25%)
		leucine-rich repeat	80..101	CDD:275380	9/20 (45%)
		LRR_8	100..161	CDD:290566	23/81 (28%)
		leucine-rich repeat	102..125	CDD:275380	10/22 (45%)
		leucine-rich repeat	126..147	CDD:275380	7/36 (19%)
		leucine-rich repeat	151..175	CDD:275380	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45973
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940