DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Lrguk

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	XP_017448017.1	Gene:	Lrguk / 296968	RGDID:	1308226	Length:	1271	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	185/962 - (19%)
Similarity:	326/962 - (33%)	Gaps:	279/962 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KHVLNLSKQKLKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYGVCRLH 74
            |..::.|..::.::......|::.|||||.||:::|..::..:.:..||||.|::..:.|:..|.
  Rat   195 KQKVDFSSNQISEMYDLSAYHTLTQLILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGLGTLP 259

  Fly    75 CLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSISDMSYL 139
             ::.|::|.|.|.:|.||:|...|:.|:|..|.|.::..|..:..||.:||.||.|..:|::.|:
  Rat   260 -IKVLSVSNNQIETITGLEELKALQNLDLSHNQISSLHGLENHDLLEVINLEDNKIKELSEIEYI 323

  Fly   140 RN---LKELYLHGN-----------------RLTHLRQCDKCLPTSLETLTLAKNSINDLNEICT 184
            .|   |:.|.|..|                 |||.|.|    ....:|....|.|..:...|:..
  Rat   324 ENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTELDQ----QKIKVEEKVYAVNKYDPPPEVVA 384

  Fly   185 ----LSHLSNLLS---------ISIADNPCVTMI------------------------------- 205
                ::|:.|.:|         :...|.|...:|
  Rat   385 AQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPMLILTGPEACGKRELAHRLCRQFSTYFRYGACHT 449

  Fly   206 ------NSLDGFDYR--------------PFVL-------NWCMSLKYIDGFV-----------V 232
                  ...|..||.              .|:|       |:.::...::|..           :
  Rat   450 TRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNYGLNRDTVEGIARDGLASCIHMEL 514

  Fly   233 DPIESLKAEWL-----------------YSQGRGRQFRVGEQQGLAKY-----LSSVCPLVGKAL 275
            :.|.|||..:.                 |.:.:|...|...:..:::.     ::...|....|:
  Rat   515 EGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNRKFPGYFDAV 579

  Fly   276 ENENDRKLRLILSKAQHHQRQLQEEIMDNANSS----ASTSPSSHRKK-----PTSRIQSP-RFS 330
            .|.:|      |..|.....:|..|.:....::    |.|:.:|..||     |...:.|| |.:
  Rat   580 INADD------LDIAYQKLSELIREYLGLTETAKKGLAPTAGASSSKKTVSGVPAHLVPSPRRLA 638

  Fly   331 RLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSLAGSGMSSSVT 395
            ||.......|:.:     ....::::.:|  .|.:|..|..|.|    :||......|.....:.
  Rat   639 RLQADGQKTEAFL-----EVQPHAMIPEN--QNPTLPQSQDLTE----EGEAPKKEASPSHLDLP 692

  Fly   396 TKTYN------STESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETL----------MS 444
            .:|.:      ..:..|.|:.|.        ..|.:.||     :..|||..|          ..
  Rat   693 QQTQDISPKVKEEDGQPANLPPK--------ITTETEGP-----EDEPVPPVLEAGQSSTMASQE 744

  Fly   445 PDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTS-SPRRMANKCSAD 508
            |...||      ....|:|||.:.|.:.......|.|.:..|  .:...|.| ||:|:.::.:
  Rat   745 PPQHPA------PAPPLSPQLDQDKESGETKVTPNNPALSEP--AQGPDPASVSPQRVQDEGA-- 799

  Fly   509 NMQAPEKLQQSAVLADSGG-FSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQQV------- 565
                     :||.||.|.. .:..:|.....||      |.....|..:.:|..|.:|
  Rat   800 ---------ESANLASSSSTHNLPEDPSHAEIE------KPTVGSQPSLKEETPKAEVMRASTPY 849

  Fly   566 -------DNNLNCQDRLIEHVTESSAVTIQKMWRGYHTRKKTNKDIAERLQRRRTQEYIEQLGKD 623
                   |::...:::.:..:..|         |...||....:.:|....||.|.:.:....::
  Rat   850 PEIPPPQDSSTKVREQPVALLPRS---------RLAPTRLPQPQTLAPLQSRRPTPKLLSPSREE 905

  Fly   624 MLLTKAQLENERKIQQLQMQAINALWKKVSTMEVDPKGIPAAAEQGEDSNGGGSGHLSLDQNSAA 688
            .|.|.::            |..|...:.:.|.:.||..:|..:..........|.|.......|.
  Rat   906 ALGTSSE------------QTPNPSPRSLPTQDGDPSKLPPISPPQSKPPQNPSPHAVHSPQQAQ 958

  Fly   689 VVNDLAKRCTMLTD--QVQMLQSSIGTIVNCLTMVCNLPQDAIKKQAEIIDCSSTQTDLIAVHTP 751
            |......:..:::.  |.|.||              :.|:...:::|..:...:........|.|
  Rat   959 VEKGSEVKLPLISPPVQEQALQ--------------HTPKPPQEEEAPTVRLPNIPAPSTEPHLP 1009

  Fly   752 QIEDLTNFPFTKTRPSTLALESKHEAALACPKIDELND---VDLKETQEDSE 800
            |        .|:.||:     ||.......||:...:.   :||:.|....|
  Rat  1010 Q--------NTEPRPA-----SKPARERKTPKVGRASSKKVLDLQATPHSQE 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	1/19 (5%)
		leucine-rich repeat	32..53	CDD:275380	8/20 (40%)
		LRR_RI	<49..189	CDD:238064	45/163 (28%)
		LRR_4	76..115	CDD:289563	13/38 (34%)
		leucine-rich repeat	76..97	CDD:275380	8/20 (40%)
		LRR_8	97..152	CDD:290566	20/74 (27%)
		LRR_4	97..137	CDD:289563	14/39 (36%)
		leucine-rich repeat	98..119	CDD:275380	6/20 (30%)
		leucine-rich repeat	120..141	CDD:275380	9/20 (45%)
		LRR_8	140..200	CDD:290566	18/92 (20%)
		leucine-rich repeat	142..165	CDD:275380	9/39 (23%)
		leucine-rich repeat	166..190	CDD:275380	5/27 (19%)
		IQ	581..599	CDD:197470	4/17 (24%)
Lrguk	XP_017448017.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910