DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Lrrcc1

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001094115.3	Gene:	Lrrcc1 / 266808	RGDID:	628722	Length:	1025	Species:	Rattus norvegicus

Alignment Length:	981	Identity:	199/981 - (20%)
Similarity:	353/981 - (35%)	Gaps:	282/981 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 HVLNLSKQKLKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYGVCRLHC 75
            |.:||....:.|:...|...::|.|.|..|::.:|:.:::..|:.||:|:.|.:.|:.|:..|..
  Rat    41 HAINLHCNNISKITSIDHIWNLRHLDLSSNQISQIEGLNTLTKLCTLNLSCNLITRVEGLEALVN 105

  Fly    76 LRELNLSFN------GILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLEC---LNLADNSI- 130
            |..||||:|      |::.:.|||  ..||.::|..|.|.:|.||     |:|   |:...|.|
  Rat   106 LTRLNLSYNHISDLSGLIPLHGLK--YKLRYIDLHSNYIDSIHHL-----LQCTVGLHFLTNLIL 163

  Fly   131 ---GSISDMSYLRNLKELYLHGNRLTHLRQCDKCL-----PTSLETLTLAKNSINDLNEICTLSH 187
               |..:.:..:...:.:.|  ..|..||..| |.     |.|||       .:|..:..|....
  Rat   164 EKDGEGNPICLVPGYRAIIL--QTLPQLRILD-CKNIFGEPVSLE-------EMNSSHLQCFEGL 218

  Fly   188 LSNLLSISIADNPC-VTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQ 251
            |.||:|   :|:|. ::....:|.           ||...||  |:.|:|              :
  Rat   219 LDNLVS---SDSPLNISEDEVVDN-----------MSAPPID--VLPPLE--------------E 253

  Fly   252 FRVGEQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEE----IMDNA------- 305
            |....::.:...|.|.|....:.:.:||:.:..:.|.|......||..|    ::||.
  Rat   254 FTSTPEENVLTSLLSACSSEPEKINHENNFQNEMKLQKLDDQILQLLNETNNSLIDNVPEKDLRP 318

  Fly   306 ---NSSASTSPSSHRK----KPTSRIQSPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTN 363
               ....|.|...:||    |.:.|.:.|.::|         ::.:..|.|.:|.:.||.|....
  Rat   319 KRDTDITSESDYGNRKECSRKVSRRTKIPYYTR---------TIQSIKHHNKNNGAFVSCNRKMR 374

  Fly   364 ----HSLQMSISLI--ENIKNDGEGFSLAGSGM----SSSVTTKTYNS--------------TES 404
                ..|.:..||:  .|::...|    ..:||    .|:....||.|              .|.
  Rat   375 QPYLRDLYVRSSLVNCNNLREVDE----QKNGMIKVDKSASNDNTYRSLVEQLDQEREMRWKAEQ 435

  Fly   405 TPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAAVAQRVTVTALNPQLHKTK 469
            |.:.:.  .|.|:..        ..|...|.|.....:.:..:..|...:|.....|...:|:.:
  Rat   436 TEKKLM--DYIDELH--------KQANEKKDVHSQAIITTDRLKDAIFKERHCKAQLEVIVHRLQ 490

  Fly   470 INKNKDNKLNLPRVRSPQ---LKRNQSPTSSPRRMANKCSADNMQAPEKLQQSAVLADSGGFSTD 531
             |:.|...:.|.:.|..|   ::..::...:..:| .|..|...||..:|.|...|..|..
  Rat   491 -NEIKKLTIELMKARDQQEDHIRHLRTLERALEKM-EKQKAQQQQAQMRLIQEVELKASAA---- 549

  Fly   532 DDGEQINI---------EKLRAIRKMAAQKQQQMHQEQLKQQVDNNLNCQDRLIEHVTESS---- 583
              ..:||:         |:::.:..:.|.|:|:..||...::..|:...||.|.:.:::..
  Rat   550 --DREINLLRTSLRQEKEQVQQLHDLLALKEQEHRQEIETREFFNDAEFQDALTKRLSKEERKHE 612

  Fly   584 --------------------------AVTIQKMWRGYHTRKKTNKDIAERLQR--------RRTQ 614
                                      |:|::.  |.:...:...:|:|..|.:        :|.:
  Rat   613 QEVKEYQEKINILNQQYLDLENEFRIALTVEA--RRFKDVQDGFEDVATELAKSKHALIWAQRKE 675

  Fly   615 EYIEQLGKDML-LTKAQLENERKIQQLQMQAINALWKKVSTMEV-----DPKGIP---------- 663
            .....|.||:. :.|.|.....::.:|:.:|...|..:::|:|:     ..|.|.
  Rat   676 NESSSLIKDLTSMVKEQKTKLSEVCKLKQEAAANLQNQINTLEILIEDDKQKSIQIELLKHEKNQ 740

  Fly   664 -----AAAEQ---GEDSNGGGSGH------LSLDQNSA---AVVNDLAK---------------- 695
                 ||.|.   |..:.....||      .||.|:..   |.:..|.:
  Rat   741 LISELAAKESLIYGLRTERKVWGHELAYQGTSLSQSRGKLEAQIESLCRENESLRKTHESDCDAL 805

  Fly   696 --RCTMLTD-----------------QVQMLQSSIGTIVNCLTMVCNLPQDAIKKQAEIIDCSST 741
              :|.::.|                 |::|||..|..|..|       .|:.:.::...:|   :
  Rat   806 RIKCKIIEDQTETIRKLKDGLQEKDGQIKMLQEQITIIEKC-------SQEQLNEKTSQLD---S 860

  Fly   742 QTDLIAVHTPQIEDLTNFPFTKTRPSTLALESKHEAALACPK--------IDELNDVDLKETQED 798
            ..:.:..|..:.|.|..    :.:...|.||...:|.....|        :..| :..:||.:|.
  Rat   861 IVEKLERHNERKEKLKQ----QLKAKELELEEIRKAYSTLNKKWHDKGELLSNL-ETQVKEVKEK 920

  Fly   799 SENLDK 804
            .||.:|
  Rat   921 FENKEK 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	5/19 (26%)
		leucine-rich repeat	32..53	CDD:275380	5/20 (25%)
		LRR_RI	<49..189	CDD:238064	44/157 (28%)
		LRR_4	76..115	CDD:289563	17/44 (39%)
		leucine-rich repeat	76..97	CDD:275380	10/26 (38%)
		LRR_8	97..152	CDD:290566	15/61 (25%)
		LRR_4	97..137	CDD:289563	14/46 (30%)
		leucine-rich repeat	98..119	CDD:275380	8/20 (40%)
		leucine-rich repeat	120..141	CDD:275380	6/27 (22%)
		LRR_8	140..200	CDD:290566	17/64 (27%)
		leucine-rich repeat	142..165	CDD:275380	7/27 (26%)
		leucine-rich repeat	166..190	CDD:275380	5/23 (22%)
		IQ	581..599	CDD:197470	3/47 (6%)
Lrrcc1	NP_001094115.3	PPP1R42	25..197	CDD:411060	48/165 (29%)
		leucine-rich repeat	40..61	CDD:275378	5/19 (26%)
		leucine-rich repeat	62..83	CDD:275378	5/20 (25%)
		leucine-rich repeat	84..105	CDD:275378	7/20 (35%)
		leucine-rich repeat	106..131	CDD:275378	10/26 (38%)
		leucine-rich repeat	132..145	CDD:275378	5/12 (42%)
		leucine-rich repeat	158..188	CDD:275380	5/31 (16%)
		Smc	426..>758	CDD:224117	60/351 (17%)
		Smc	<639..1020	CDD:224117	56/305 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910