DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cep97 and T05H4.3

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_001343670.1	Gene:	T05H4.3 / 188149	WormBaseID:	WBGene00020266	Length:	1150	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	115/509 - (22%)
Similarity:	210/509 - (41%)	Gaps:	105/509 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LILDENELQKIDNIDSYLKIETLSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGL-KECIHL 98
            |.|.:.:|.|:..|...:.::.||:.:|:|..:..:.||.||:.|:.|||.|..||.| ...:|
Worm   632 LELCDQKLTKLTGIQELVSLQFLSVRKNKLTSLKKLNRLPCLKLLDASFNHISKIEQLPSSLLH- 695

  Fly    99 RVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSISDMSYLRNLKELYLHGNRLTHLRQCDKCLP 163
              ::|..|.::|:        :.|.:|.              |.:.|.||.|::..::..:.|:
Worm   696 --VDLSHNKLQTL--------VFCQSLG--------------NTRHLLLHRNQIKSMKGVESCV- 735

  Fly   164 TSLETLTLAKNSINDLNEICTLSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYID 228
             .|||..:..|.:.|.:::..|..:..|..:.:::|    :::|.:|  |||.|:.....|..:|
Worm   736 -QLETFFVNDNLLKDKSDVELLKTMPKLTHLDMSNN----ILSSAEG--YRPRVMQAAQFLISLD 793

  Fly   229 GFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHH 293
            ..:: |:|......:....||....:.|:         :||      |.:|.::|.:...|.:
Worm   794 RQII-PLEERHVNTMKQTTRGLSLELIER---------ICP------EWKNKKELMICDQKIE-- 840

  Fly   294 QRQLQEEIMDNANSSASTSPSSHRKKPTSRIQSPRFSRLSGRQGSPESM-VNSYHGNSS------ 351
            |..|::..|:..:.......|.:|......|.|...:.|.......:|: ||.  |.:|
Worm   841 QIILEKSQMEELSQIRLIDLSKNRLSSVREISSFNITHLILNNNCLKSIAVND--GQTSLQPFPY 903

  Fly   352 -NNSIVSDNGSTNHS-LQMSISLIENIKNDGEGFSLAGSGMS-------------------SSVT 395
             .|..:|:|..:|.| |::.|.|:..:||    .:|:.:.:|                   :|:.
Worm   904 LENLDISNNSISNTSILRLGIPLLLKLKN----INLSQNALSRFDCSLFDLPNLESVDLSNNSIK 964

  Fly   396 T------KTYNSTESTPRNITP-NPYNDQTFISQTPSGGPLAAASKMVPVPE--TLMSPDVCPAA 451
            |      ||..|.......:|. .|.:....:|...|...||:.:.:.|:.|  ||.:.|....:
Worm   965 TIIRRPLKTLTSLNLQNNKLTTLTPLSCPNLVSLDISNNKLASCASLKPLCECKTLENLDCRNNS 1029

  Fly   452 VAQ-RVTVTALNPQLHKTKINKNKD----NKLNLPRVRSPQLKRNQSPTSSPRR 500
            |.: ||.|..:..|:  ..:.|..|    |::.:.:.|   |.|.....|..||
Worm  1030 VTERRVYVDFIKAQV--PSVRKLDDEIMSNEIEITKRR---LSRANDLISMSRR 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		leucine-rich repeat	32..53	CDD:275380	5/17 (29%)
		LRR_RI	<49..189	CDD:238064	34/140 (24%)
		LRR_4	76..115	CDD:289563	13/39 (33%)
		leucine-rich repeat	76..97	CDD:275380	9/21 (43%)
		LRR_8	97..152	CDD:290566	11/54 (20%)
		LRR_4	97..137	CDD:289563	6/39 (15%)
		leucine-rich repeat	98..119	CDD:275380	3/20 (15%)
		leucine-rich repeat	120..141	CDD:275380	2/20 (10%)
		LRR_8	140..200	CDD:290566	13/59 (22%)
		leucine-rich repeat	142..165	CDD:275380	5/22 (23%)
		leucine-rich repeat	166..190	CDD:275380	6/23 (26%)
		IQ	581..599	CDD:197470
T05H4.3	NP_001343670.1	leucine-rich repeat	69..91	CDD:275380
		leucine-rich repeat	92..113	CDD:275380
		leucine-rich repeat	114..135	CDD:275380
		leucine-rich repeat	136..157	CDD:275380
		leucine-rich repeat	158..181	CDD:275380
		leucine-rich repeat	182..206	CDD:275380
		leucine-rich repeat	629..650	CDD:275380	5/17 (29%)
		PLN00113	645..>1005	CDD:331614	90/416 (22%)
		leucine-rich repeat	651..672	CDD:275380	6/20 (30%)
		leucine-rich repeat	673..692	CDD:275380	9/18 (50%)
		leucine-rich repeat	693..714	CDD:275380	6/45 (13%)
		leucine-rich repeat	715..761	CDD:275380	11/47 (23%)
		leucine-rich repeat	762..815	CDD:275380	14/59 (24%)
		leucine-rich repeat	816..851	CDD:275380	10/51 (20%)
		leucine-rich repeat	855..875	CDD:275380	4/19 (21%)
		leucine-rich repeat	876..903	CDD:275380	6/28 (21%)
		leucine-rich repeat	904..952	CDD:275380	12/51 (24%)
		leucine-rich repeat	953..973	CDD:275380	2/19 (11%)
		leucine-rich repeat	974..994	CDD:275380	3/19 (16%)
		leucine-rich repeat	995..1019	CDD:275380	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840