DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and R02F11.4

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_504289.1	Gene:	R02F11.4 / 178871	WormBaseID:	WBGene00019842	Length:	630	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	170/711 - (23%)
Similarity:	267/711 - (37%)	Gaps:	210/711 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESGEEKHVLNLSK---QK---LKKVPKQD--DAH--SIRQLILDENELQKIDNIDSYLKIETLSL 59
            |..|.|| |.:|.   ||   :|..||..  ||.  .|.:.|.|.|          |..:| |.|
Worm    75 EYSEVKH-LKISGNCFQKFTYIKLFPKCQIIDARDCQINKFIADFN----------YNLLE-LHL 127

  Fly    60 ARNQLLRMYGVCRLHCLRELNLSFNGI-----LSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVN 119
            |||||.....:.|...|:.|:||.|.|     .|::      :|.:|||.||.:..|..|:..|.
Worm   128 ARNQLKETNQLGRFENLKILDLSNNLIEPPVSFSLK------NLEILNLSGNFLNEIPDLSKCVA 186

  Fly   120 LECLNLADNSIGSISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICT 184
            |:.::||||   .|||::.:..|                  ..||:|:.|.::.|||.||::...
Worm   187 LQTISLADN---KISDLTTITKL------------------ICPTNLKNLDISSNSIEDLSQFSV 230

  Fly   185 LSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCM-SLKYIDGFVVDPIESLKAEWLYSQGR 248
            ||....|....:|.||.:|.:...|.||||.::...|. .|..|||..::.....:.|||..||.
Worm   231 LSTFKKLEEFVVAGNPSITSVLDSDLFDYRSYIFACCSEQLHTIDGQKIEDQVQTEGEWLALQGS 295

  Fly   249 GRQFRVGEQQGLAKYLSSVCPLVG----------KALENENDRKLRLILSKAQHHQRQLQEEIMD 303
            .::...|....|.:.::|..|..|          ||||.....|:      .:.|..:..|:...
Worm   296 IKKIGPGNHDALCQQIASHFPDSGPPTPAQKSCHKALEKRRSMKV------PEKHLEEFSEDTDR 354

  Fly   304 NANSSASTSPSSHRKKPTSRIQSPRFSRLSGRQG---SPESMVNSYHGNSSNNSIVSDNGSTNHS 365
            ..||                :.|| |...:|:.|   :||:       :.|:..|     ..|.:
Worm   355 TENS----------------VYSP-FREWNGKIGALMTPEA-------SGSSRRI-----PVNKN 390

  Fly   366 LQMSISLIENIKNDGEGFSLAGSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLA 430
            |:| .|..|..||                  ||:.....|    :||.|.:    :..|.|...:
Worm   391 LRM-CSPPEARKN------------------KTFKFQNET----SPNRYPE----NFRPLGSTRS 428

  Fly   431 AASKMVPVPETLMSPDVCPAAVAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPT 495
            .:::.|          :|.:......||             ..:.....|||:....|:|.:
Worm   429 ISTETV----------ICSSRTEVSFTV-------------DGRSESTPLPRIDCAPLERKE--- 467

  Fly   496 SSPRRMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQ 560
                           |.||:....:| ||......:.|||         :::..|..::.:  ::
Worm   468 ---------------QEPEQRHTPSV-ADVTYVGEESDGE---------LKQKVAYLEKSV--DE 505

  Fly   561 LKQQVDNNLNCQDRLIEHVTESSAVTIQKMWRGYHTRKKTNKD-IAERLQRRRTQEYIEQLGKDM 624
            ||.|.:|.....|||::.:.|..|...: ||:.......|.:: |:..|.......::.|:..||
Worm   506 LKIQNENLTAINDRLVDTLEEFKAEQAE-MWKAIRNMIPTPQNVISNFLVENEDGHHVHQVRWDM 569

  Fly   625 LLTK-----------AQLE---NERKIQQL--------QMQAI--NALWKKVS-TMEVDPK 660
            ...|           .|::   |..:|..|        |:||:  |.|..::| .:.:.||
Worm   570 PAVKEFRIFVDGNQCGQIKGKNNSARITDLTSNEPHTVQIQAVGNNGLHGEISKKLHIVPK 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	10/29 (34%)
		leucine-rich repeat	32..53	CDD:275380	5/20 (25%)
		LRR_RI	<49..189	CDD:238064	46/144 (32%)
		LRR_4	76..115	CDD:289563	14/43 (33%)
		leucine-rich repeat	76..97	CDD:275380	7/25 (28%)
		LRR_8	97..152	CDD:290566	18/54 (33%)
		LRR_4	97..137	CDD:289563	17/39 (44%)
		leucine-rich repeat	98..119	CDD:275380	8/20 (40%)
		leucine-rich repeat	120..141	CDD:275380	8/20 (40%)
		LRR_8	140..200	CDD:290566	14/59 (24%)
		leucine-rich repeat	142..165	CDD:275380	2/22 (9%)
		leucine-rich repeat	166..190	CDD:275380	9/23 (39%)
		IQ	581..599	CDD:197470	4/17 (24%)
R02F11.4	NP_504289.1	leucine-rich repeat	57..78	CDD:275380	1/2 (50%)
		LRR_RI	<118..245	CDD:238064	49/164 (30%)
		leucine-rich repeat	122..143	CDD:275380	9/21 (43%)
		LRR_8	143..197	CDD:290566	21/62 (34%)
		leucine-rich repeat	144..164	CDD:275380	7/25 (28%)
		LRR_4	163..205	CDD:289563	17/50 (34%)
		leucine-rich repeat	165..186	CDD:275380	8/20 (40%)
		leucine-rich repeat	187..211	CDD:275380	10/44 (23%)
		leucine-rich repeat	212..236	CDD:275380	9/23 (39%)
		leucine-rich repeat	237..256	CDD:275380	5/18 (28%)
		DUF2730	<480..557	CDD:287743	19/88 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007484
OrthoInspector	1	1.000	-	-		oto19750
orthoMCL	1	0.900	-	-		OOG6_107805
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840