DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cep97 and sds-22

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_495653.1	Gene:	sds-22 / 174266	WormBaseID:	WBGene00011637	Length:	326	Species:	Caenorhabditis elegans

Alignment Length:	268	Identity:	70/268 - (26%)
Similarity:	123/268 - (45%)	Gaps:	46/268 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SIRQLILDENELQKIDNIDSYLKIETLSLARNQLLRMYGVCRLHCLRELNLSFNGILSIEGLKEC 95
            ::..|.|.||:|.:|.:::|.:.:.:|.|:.|::.::.|:.:|..|..|.|..|.|..||.|:..
Worm    82 TLTSLDLYENQLTEISHLESLVNLVSLDLSYNRIRQINGLDKLTKLETLYLVSNKIEKIENLEAL 146

  Fly    96 IHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSISDMSYLRNLKELYLHGNRLTHLRQCDK 160
            ..|::|.|..|.||.||::...|||:.|.:..|.|..:..:..|:.|..|.|.|||:..:...::
Worm   147 TQLKLLELGDNRIKKIENIGHLVNLDELFIGKNKIRQLEGVETLQKLSVLSLPGNRIVKIENVEQ 211

  Fly   161 CLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADNPCVTMINSLDGFDYRPFVLNWCMSLK 225
            .  .:|:.|.|:...:.|::.:   ..|:|||.:.:|:|                       .:|
Worm   212 L--NNLKELYLSDQGLQDIHGV---EPLTNLLLLDVANN-----------------------EIK 248

  Fly   226 YIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYLSSVCPLVGKALE---------NENDR 281
            ...|  |:.:|||...|. :..:...|...||....|.|.:|      .||         |:..|
Worm   249 TFSG--VERLESLNDFWA-NDNKVESFSEIEQLSKLKGLQTV------YLERNPFYFNDTNQYRR 304

  Fly   282 KLRLILSK 289
            |:.:.|::
Worm   305 KVMMTLTQ 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	70/268 (26%)
		leucine-rich repeat	32..53	CDD:275380	7/20 (35%)
		LRR_RI	<49..189	CDD:238064	39/139 (28%)
		LRR_4	76..115	CDD:289563	16/38 (42%)
		leucine-rich repeat	76..97	CDD:275380	8/20 (40%)
		LRR_8	97..152	CDD:290566	20/54 (37%)
		LRR_4	97..137	CDD:289563	14/39 (36%)
		leucine-rich repeat	98..119	CDD:275380	8/20 (40%)
		leucine-rich repeat	120..141	CDD:275380	5/20 (25%)
		LRR_8	140..200	CDD:290566	15/59 (25%)
		leucine-rich repeat	142..165	CDD:275380	6/22 (27%)
		leucine-rich repeat	166..190	CDD:275380	5/23 (22%)
		IQ	581..599	CDD:197470
sds-22	NP_495653.1	leucine-rich repeat	40..59	CDD:275380
		leucine-rich repeat	60..82	CDD:275380	70/268 (26%)
		LRR_8	82..137	CDD:290566	16/54 (30%)
		LRR_4	83..123	CDD:289563	11/39 (28%)
		leucine-rich repeat	83..104	CDD:275380	7/20 (35%)
		LRR_4	104..144	CDD:289563	12/39 (31%)
		leucine-rich repeat	105..126	CDD:275380	5/20 (25%)
		LRR_8	125..181	CDD:290566	21/55 (38%)
		LRR_4	125..167	CDD:289563	16/41 (39%)
		leucine-rich repeat	127..148	CDD:275380	8/20 (40%)
		leucine-rich repeat	149..170	CDD:275380	8/20 (40%)
		leucine-rich repeat	171..192	CDD:275380	5/20 (25%)
		leucine-rich repeat	193..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..236	CDD:275380	5/23 (22%)
		leucine-rich repeat	256..283	CDD:275380	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910