Protein Alignment Cep97 and LRRIQ3

DIOPT Version :10

• Sequence 1: NP_608811.2
• Gene: Cep97 / 33610
• FlyBaseID: FBgn0031575
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001099129.1
• Gene: LRRIQ3 / 127255
• HGNCID: 28318
• Length: 624
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 127/690 - (18%)
• Similarity: 234/690 - (33%)
• Gaps: 258/690 - (37%)

  Fly    81 LSFNG--ILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIGSISDMSY---LR 140
            :.|||  :.|:|.|:.||.|||.....|.|..|..|.:.:.|..|:|..|.|.|:.:..:   |:
Human    33 VKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTKFWNGLK 97

  Fly   141 NLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISIADNPCVTMI 205
            |||.||||.|....|:                        .||.||....|:::::.|.|    :
Human    98 NLKLLYLHDNGFAKLK------------------------NICVLSACPTLIALTMFDCP----V 134

  Fly   206 NSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLAKYLSSVCPL 270
            :...|  ||..::|....||.:|..|:.. |.:...|...:    :|:....    :...:.||.
Human   135 SLKKG--YRHVLVNSIWPLKALDHHVISD-EEIIQNWHLPE----RFKACNH----RLFFNFCPA 188

  Fly   271 VGKALENEND--------RKLRLI----------------------LSKAQHHQRQLQEEI---- 301
            :.|....|.:        .|:..|                      ||....|:::.||:|
Human   189 LRKGTTYEEEINNIKHITSKINAILAHNSPVLIVQRWIRGFLVRKNLSPVFFHKKKQQEKIIRGY 253

  Fly   302 -----------------------------------------MDNANSSASTSPSSHRKKPTSRIQ 325
                                                     :|..||      |.|||..:|.:.
Human   254 EAKWIYITKGYEDKLLKDLFFKPETNIKGKLAYWKHNIYYPVDLKNS------SEHRKHVSSILC 312

  Fly   326 SPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQMSISLIENIKNDGEGFSL----A 386
            ..:...|..:..:...::..  |..|.:.||.:...|  |.::|:            |.|    :
Human   313 ELKPKDLGMKSKTSRHLIQK--GQESEDEIVDEKLDT--SFRISV------------FKLPIYTS 361

  Fly   387 GSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAA 451
            ||..:::|..:                 ..|.|....|.  |:....     |:.::..|:
Human   362 GSLKNNAVLRE-----------------KKQHFFPAYPQ--PIYTTH-----PKPIIKKDI---- 398

  Fly   452 VAQRVTVTALNPQLHKTKINKNKDNKLNLPRVRSPQLKRNQSPTSSPRRMANKCSADNMQAPEKL 516
                                               :|:|:.....:|:|           |..||
Human   399 -----------------------------------RLERSMKEFFAPQR-----------AGMKL 417

  Fly   517 QQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQEQLKQQVDNNLN----CQDRLIE 577
            :   ..:|...:.|:...::.:.||:|.: .||     |:.:|:::..|:.:||    ...:|||
Human   418 R---TFSDIDKYYTEQKKQEYHKEKVRVV-AMA-----QVARERVRVAVNEHLNQKKYATQKLIE 473

  Fly   578 HVTESSAVTIQKMWR---GYHTRKKTNKD--IAERLQRRRTQEYIEQLGKD-MLLTKAQLENER- 635
            ...|:...:::::|:   .|..:.:..|.  :.|:.|:...:..::.|..: .|||:..|:.:|
Human   474 ENKETIQNSLRQVWQNRFNYLEKARERKALFLKEKSQKASERLLVQNLNNERTLLTRGLLKIDRL 538

  Fly   636 ------------------KIQQLQMQAINALWKKVSTMEV 657
                              |.::.:...:..: |||.:.|:
Human   539 EKNEAVLKEKSLIVKQKLKAEKYRKNLLKEM-KKVRSQEI 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380
		PPP1R42	13..229	CDD:455733	44/152 (29%)
		leucine-rich repeat	32..53	CDD:275380
		leucine-rich repeat	76..97	CDD:275380	7/17 (41%)
		leucine-rich repeat	98..119	CDD:275380	7/20 (35%)
		leucine-rich repeat	120..141	CDD:275380	7/23 (30%)
		leucine-rich repeat	142..165	CDD:275380	8/22 (36%)
		leucine-rich repeat	166..190	CDD:275380	4/23 (17%)
		IQ	581..599	CDD:197470	3/20 (15%)
LRRIQ3	NP_001099129.1	PPP1R42	33..>119	CDD:455733	33/109 (30%)
		LRR 1	51..72		7/20 (35%)
		leucine-rich repeat	52..73	CDD:275378	7/20 (35%)
		LRR 2	73..94		6/20 (30%)
		leucine-rich repeat	74..98	CDD:275378	7/23 (30%)
		LRR 3	98..119		11/44 (25%)
		leucine-rich repeat	99..123	CDD:275378	12/47 (26%)
		leucine-rich repeat	124..135	CDD:275378	3/14 (21%)