Protein Alignment Cep97 and CNTRL

DIOPT Version :9

• Sequence 1: NP_608811.2
• Gene: Cep97 / 33610
• FlyBaseID: FBgn0031575
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_011516468.1
• Gene: CNTRL / 11064
• HGNCID: 1858
• Length: 2340
• Species: Homo sapiens
• Alignment Length: 860
• Identity: 169/860 - (19%)
• Similarity: 319/860 - (37%)
• Gaps: 257/860 - (29%)

  Fly     4 DESGEEKH--VLNLSKQKLKKVPKQDDAHSIRQLILD-----ENELQKIDNIDSYLKIETLSLAR 61
            |..|.:.|  |..:::..:||:.|||:...|:.|.|.     ..:.:.|:|::..:|:|.|:|:.
Human    70 DHKGADSHAGVRYITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSY 134

  Fly    62 NQLLRMYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLA 126
            |.:.::..:.:|..|||||||:|.|..|||::...:|:.|||.||.   |||:
Human   135 NLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNE---IEHI------------ 184

  Fly   127 DNSIGSISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNL 191
                             .::| |.:|           .||..|.|..|.|:.|.:|..|..|.:|
Human   185 -----------------PVWL-GKKL-----------KSLRVLNLKGNKISSLQDISKLKPLQDL 220

  Fly   192 LSISIADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGE 256
            :|:.:.:||.||:          |..|.:.:       |.:..:|||:.:.:.:|.|...|   |
Human   221 ISLILVENPVVTL----------PHYLQFTI-------FHLRSLESLEGQPVTTQDRQEAF---E 265

  Fly   257 QQGLAKYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEI--MDNANSSASTSPSSHRKK 319
            :..|.:.         :.||.:.::|: :...:.:..|.:..|||  .|..|.|.
Human   266 RFSLEEV---------ERLERDLEKKM-IETEELKSKQTRFLEEIKNQDKLNKSL---------- 310

  Fly   320 PTSRIQSPRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSL-QMSISLIENIKNDGEGF 383
                              ..|:|:.    ..|...:.||..:.|..| |.:|.|
Human   311 ------------------KEEAMLQ----KQSCEELKSDLNTKNELLKQKTIEL----------- 342

  Fly   384 SLAGSGMSSSVTTKTYN----------STESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPV 438
                    :....|.|.          ..:..|.|..|:.|.:   |.:.|...|....|:   .
Human   343 --------TRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAE---IDKAPDESPYIGKSR---Y 393

  Fly   439 PETLMSPDVCPAAVAQRVTVTALNP--QLHKTKIN-----------KNKDNKLNLPRVRSPQLKR 490
            ...:.:.:......||.|.:..:.|  ||....:|           ::|:.|::..:.|..:|
Human   394 KRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL-- 456

  Fly   491 NQSPTSSPRRMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQI-------NIEKLRAIRKM 548
             ........:...:.:.:..|..|.:|...:         .:.|:.:       .::.:..:|:.
Human   457 -HDEIEKAEQQILRATEEFKQLEEAIQLKKI---------SEAGKDLLYKQLSGRLQLVNKLRQE 511

  Fly   549 AAQKQQQMHQEQLKQQVD-------------NNLNCQDRLIEHVTESSAVTIQKMWRGYHTRKKT 600
            |...:.||  |:.||::.             ::|:.:|....|:            :...:.|:.
Human   512 ALDLELQM--EKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHM------------KAQKSGKEQ 562

  Fly   601 NKDIAERLQRR---RTQEYIEQLGKDMLLTKAQLENERKIQQLQMQAINALWKKVSTMEVDPKGI 662
            ..||..:..::   |..|.:.::.|:   |:...:.|.::.:.|:.|..||.|       |.:|:
Human   563 QLDIMNKQYQQLESRLDEILSRIAKE---TEEIKDLEEQLTEGQIAANEALKK-------DLEGV 617

  Fly   663 PAAAEQGEDSNGGGSGHLSLDQNSAAVVNDLAKRCTMLTDQVQMLQSSIGTIVNCLTMVCNLPQD 727
            .:..   ::..|...|..:..||          .|..|.|:.:       |::..||.|     :
Human   618 ISGL---QEYLGTIKGQATQAQN----------ECRKLRDEKE-------TLLQRLTEV-----E 657

  Fly   728 AIKKQAEII--DCSSTQTDLIAVHTP-QIEDLTNFPFTKTRPSTLALESKHEAALACPKIDELND 789
            ..:.|.||:  |..:.:.:|..:.:. |.:...|....:|:....|.|::.||.|      .|.|
Human   658 QERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARL------NLRD 716

  Fly   790 VDLKETQEDSENLDK 804
            .:..:.:|:.|.:.:
Human   717 AEANQLKEELEKVTR 731

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	7/21 (33%)
		leucine-rich repeat	32..53	CDD:275380	5/25 (20%)
		LRR_RI	<49..189	CDD:238064	39/139 (28%)
		LRR_4	76..115	CDD:289563	21/38 (55%)
		leucine-rich repeat	76..97	CDD:275380	12/20 (60%)
		LRR_8	97..152	CDD:290566	11/54 (20%)
		LRR_4	97..137	CDD:289563	9/39 (23%)
		leucine-rich repeat	98..119	CDD:275380	9/20 (45%)
		leucine-rich repeat	120..141	CDD:275380	0/20 (0%)
		LRR_8	140..200	CDD:290566	15/59 (25%)
		leucine-rich repeat	142..165	CDD:275380	3/22 (14%)
		leucine-rich repeat	166..190	CDD:275380	9/23 (39%)
		IQ	581..599	CDD:197470	0/17 (0%)
CNTRL	XP_011516468.1	leucine-rich repeat	100..119	CDD:275378	3/18 (17%)
		LRR_4	126..167	CDD:289563	18/40 (45%)
		leucine-rich repeat	127..148	CDD:275380	5/20 (25%)
		LRR_8	148..205	CDD:290566	29/100 (29%)
		leucine-rich repeat	149..170	CDD:275380	12/20 (60%)
		LRR_4	169..213	CDD:289563	20/87 (23%)
		leucine-rich repeat	171..194	CDD:275380	12/66 (18%)
		leucine-rich repeat	195..219	CDD:275380	9/23 (39%)
		leucine-rich repeat	220..246	CDD:275380	9/42 (21%)
		SMC_prok_B	<435..1119	CDD:274008	61/364 (17%)
		DUF342	<513..610	CDD:302792	18/113 (16%)
		Pro-rich	<1176..1299	CDD:291893
		COG4372	1320..>1602	CDD:226809
		Mplasa_alph_rch	1525..2221	CDD:275316

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910