DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cep97 and Lrrc49

DIOPT Version :9

Sequence 1:	NP_608811.2	Gene:	Cep97 / 33610	FlyBaseID:	FBgn0031575	Length:	806	Species:	Drosophila melanogaster
Sequence 2:	NP_663591.3	Gene:	Lrrc49 / 102747	MGIID:	2442689	Length:	752	Species:	Mus musculus

Alignment Length:	699	Identity:	157/699 - (22%)
Similarity:	263/699 - (37%)	Gaps:	178/699 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SGEEKHV----LNLSKQKLKKVPKQDDAHSIRQLILDENELQKIDNIDSYLKIETLSLARNQLLR 66
            |.|||.:    |.|.:|||...|..|....:|.|....|.:.:|.||.:..::..|.|..||:..
Mouse   150 SSEEKTLYSDRLTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEE 214

  Fly    67 MYGVCRLHCLRELNLSFNGILSIEGLKECIHLRVLNLEGNNIKTIEHLNTNVNLECLNLADNSIG 131
            :.|:..|..||.|.|..|.|..|..|:...:|.||:|.||.|..||::|...:|..||||.|.:.
Mouse   215 ISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARNLLS 279

  Fly   132 SISDMSYLRNLKELYLHGNRLTHLRQCDKCLPTSLETLTLAKNSINDLNEICTLSHLSNLLSISI 196
            .:.:::.|.:|.||.|..|::|.:|..|. || .|:.|.|:.|:|.....:..|:..::|..|:.
Mouse   280 HVDNLNGLDSLTELNLRHNQITFVRDVDN-LP-CLQRLFLSFNNITSFESVSCLAESTSLSDITF 342

  Fly   197 ADNPCVTMINSLDGFDYRPFVLNWCMSLKYIDGFVVDPIESLKAEWLYSQGRGRQFRVGEQQGLA 261
            ..||.     :.:.: |:..||...|.|:.:|         :|             |:.|::
Mouse   343 DGNPI-----AQESW-YKHTVLQNMMQLRQLD---------MK-------------RITEEE--- 376

  Fly   262 KYLSSVCPLVGKALENENDRKLRLILSKAQHHQRQLQEEIMDNANSSASTSPSSHRKKPTSRIQS 326
               ..|..:|.|   .|.::|      :..|.|..|:|:.....|:.|.......|....:..|.
Mouse   377 ---RRVASVVAK---KEEEKK------RESHKQSLLKEKKRLTINNVARKWDLQQRVANIASTQD 429

  Fly   327 PRFSRLSGRQGSPESMVNSYHGNSSNNSIVSDNGSTNHSLQ-----MSISLIENIKNDGEGFSLA 386
            .:.|     :..|:.......||.|  :...:.||.:..|.     :|::....::.|||..||.
Mouse   430 RKDS-----ESPPQESCQLDGGNIS--AFPEEAGSLDAGLSSALQGLSVTETHLVEIDGETLSLY 487

  Fly   387 GSGMSSSVTTKTYNSTESTPRNITPNPYNDQTFISQTPSGGPLAAASKMVPVPETLMSPDVCPAA 451
            |||           :.|...||     ::.||             |..:..|..|.:..|
Mouse   488 GSG-----------ALECLDRN-----WSVQT-------------AGMVTTVSFTFIEFD----- 518

  Fly   452 VAQRVTVTALNPQLHKTKINKN---KDNKLNLPRVRS----PQLKRNQSPTSSPR---------- 499
                 .:..:.|:| |.|...:   |..:.||..::.    .||:|....|..|:
Mouse   519 -----EIVQVLPKL-KMKFPNSLHLKFRETNLVMLQQFNALAQLRRVDQLTIDPQGNPVVNFTLW 577

  Fly   500 ------RMANKCSADNMQAPEKLQQSAVLADSGGFSTDDDGEQINIEKLRAIRKMAAQKQQQMHQ 558
                  |::: .|...:...|..|...::|                |:|..|....|..:...::
Mouse   578 KYYVLFRLSH-FSMQKINGTEVTQNDMIMA----------------ERLFGILAHVASSELPQYR 625

  Fly   559 ------EQLKQQVDNNLNCQDR----LIEHVTESSAVTIQKMWRGYHTRKKTNKDIAERLQRRRT 613
                  :..|:|....|..:.:    :.|..::|      |.:.|.:|.:.|...........:.
Mouse   626 MISILGDARKKQFRYLLESKGKKPGIICEETSDS------KRFLGENTNRATLNYTTREFYHEKL 684

  Fly   614 QE----------YIEQLGKDMLLTKAQLENERKIQQLQMQAINALWKKV 652
            :|          |:|.|.|:  .|...::||         |:..||.::
Mouse   685 EEIKDKKKFCRLYVEDLVKE--ATAINMKNE---------ALQKLWPQM 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cep97	NP_608811.2	leucine-rich repeat	11..31	CDD:275380	7/23 (30%)
		leucine-rich repeat	32..53	CDD:275380	6/20 (30%)
		LRR_RI	<49..189	CDD:238064	47/139 (34%)
		LRR_4	76..115	CDD:289563	17/38 (45%)
		leucine-rich repeat	76..97	CDD:275380	8/20 (40%)
		LRR_8	97..152	CDD:290566	22/54 (41%)
		LRR_4	97..137	CDD:289563	16/39 (41%)
		leucine-rich repeat	98..119	CDD:275380	10/20 (50%)
		leucine-rich repeat	120..141	CDD:275380	7/20 (35%)
		LRR_8	140..200	CDD:290566	18/59 (31%)
		leucine-rich repeat	142..165	CDD:275380	10/22 (45%)
		leucine-rich repeat	166..190	CDD:275380	6/23 (26%)
		IQ	581..599	CDD:197470	4/17 (24%)
Lrrc49	NP_663591.3	leucine-rich repeat	160..177	CDD:275380	7/16 (44%)
		LRR_4	178..219	CDD:289563	11/40 (28%)
		leucine-rich repeat	180..201	CDD:275380	6/20 (30%)
		LRR_4	200..242	CDD:289563	14/41 (34%)
		leucine-rich repeat	202..223	CDD:275380	6/20 (30%)
		LRR_8	222..278	CDD:290566	24/55 (44%)
		LRR_4	222..264	CDD:289563	17/41 (41%)
		leucine-rich repeat	224..245	CDD:275380	8/20 (40%)
		LRR_4	244..286	CDD:289563	16/41 (39%)
		leucine-rich repeat	246..267	CDD:275380	10/20 (50%)
		LRR_8	268..322	CDD:290566	21/55 (38%)
		leucine-rich repeat	268..289	CDD:275380	7/20 (35%)
		LRR_4	289..329	CDD:289563	15/41 (37%)
		leucine-rich repeat	290..311	CDD:275380	10/22 (45%)
		leucine-rich repeat	312..336	CDD:275380	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910