Protein Alignment HTR5A and tyra-2

DIOPT Version :9

• Sequence 1: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_001033537.1
• Gene: tyra-2 / 180970
• WormBaseID: WBGene00017157
• Length: 468
• Species: Caenorhabditis elegans
• Alignment Length: 455
• Identity: 128/455 - (28%)
• Similarity: 192/455 - (42%)
• Gaps: 129/455 - (28%)

Human    29 LRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALV 93
            :.|.....::|.:|..:.|..||..|...|.||...:.:......||:.||.::|.||:.:..:|
 Worm     7 MSPVDETYTLFQILKGSALFLLVLWTIFANSLVFIVLYKNPRLQTVPNLLVGNLAFSDLALGLIV 71

Human    94 MPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVS 158
            :|||.|:.::| .|.....||:::::.|:||.||||||::.:.|||||:||..:.|..:..|..:
 Worm    72 LPLSSVYAIAG-EWVFPDALCEVFVSADILCSTASIWNLSIVGLDRYWAITSPVAYMSKRNKRTA 135

Human   159 NVMIALTWALSAVISLAPLLFGWGET-------YSEGS--EECQVSREPSYAVFSTVGAFYLPLC 214
            .:||...|..||:||||||| ||.:|       |.:.:  .:|.....|||.|:|..|:|::|..
 Worm   136 GIMILSVWISSALISLAPLL-GWKQTAQTPNLIYEKNNTVRQCTFLDLPSYTVYSATGSFFIPTL 199

Human   215 VVLFVYWKIYKA-AKFR----------VGS------------RKTNSVSPIS-----EAVEVKDS 251
            ::.|||:|||:| ||.|          |.|            .:.:.|.|.|     |..|.:||
 Worm   200 LMFFVYFKIYQAFAKHRARQIYRQKLAVSSHVIRKHIESTILHEISHVLPTSDEFAKEEEEEEDS 264

Human   252 AKQPQM------------------------------VFTVRHATVTFQPEGDTWREQ-------- 278
            ....|:                              ..|...||||...|....:.:
 Worm   265 ESSGQVENGLGNGNDAIIEEDECEDEDSDEKRDDHTSMTTVTATVTGPTEAPYMKREAKISKSVP 329

Human   279 ---------------------------------------------------KEQRAALMVGILIG 292
                                                               ||:|...::||::|
 Worm   330 IEKESAIQKREAKPMRSVMAISYEKVKRHKNRKERIYRKSLQRKPKAISAAKERRGVKVLGIILG 394

Human   293 VFVLCWIPFFLTELISPLC-SCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQ 356
            .|.:||.|||...::...| .|...|..:....|||||||..||:|||.||::|..|.|..|:.:
 Worm   395 CFTVCWAPFFTMYVLVQFCKDCSPNAHIEMFITWLGYSNSAMNPIIYTVFNRDYQIALKRLFTSE 459

Human   357  356
             Worm   460  459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	123/434 (28%)
		TM helix 1	42..68	CDD:320451	8/25 (32%)
		TM helix 2	75..101	CDD:320451	11/25 (44%)
		TM helix 3	114..144	CDD:320451	15/29 (52%)
		TM helix 4	156..177	CDD:320451	9/20 (45%)
		TM helix 5	197..226	CDD:320451	14/28 (50%)
		TM helix 6	278..308	CDD:320451	12/88 (14%)
		TM helix 7	317..342	CDD:320451	13/24 (54%)
tyra-2	NP_001033537.1	7tm_1	36..>232	CDD:278431	74/197 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46042
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920