Protein Alignment TTLL4B and TTLL4

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: XP_016860876.1
• Gene: TTLL4 / 9654
• HGNCID: 28976
• Length: 1226
• Species: Homo sapiens
• Alignment Length: 1036
• Identity: 335/1036 - (32%)
• Similarity: 502/1036 - (48%)
• Gaps: 193/1036 - (18%)

  Fly    78 PASSHHLQPH--LAAPNRNHGRIVQSSTPQHRSSAGGGSAAGATASDSVSARYSP---------- 130
            |.:|...:|:  |||...|         |..:|.|   ||........:|:.|.|
Human   173 PMASSSTEPYLCLAAAGEN---------PSGKSLA---SAISGKIPSPLSSSYKPMLNNNSFMWP 225

  Fly   131 -----------PGQKQRSPPSPRKRLTPEKVANLGGGGGGSKVGAQRIIIR--GTPPNSSTPKVA 182
                       .|.|..|||    ::.|....:.||.|..:.......:.:  ||.|..::..:|
Human   226 NSTPVPLLQTTQGLKPVSPP----KIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIA 286

  Fly   183 -ATPSNVPVVANSVLQS-------------------------EPYKKVQMLLKRAREEAFAKHTA 221
             :|.|:......||..|                         :|.|:::.      .||..|.||
Human   287 LSTASSHDTSTTSVASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRF------TEAVRKLTA 345

  Fly   222 G------------------NSAANGNGPKRSAHSPPIQAKVPPSNMSCP-----STQTLKPSPPS 263
            .                  |.:...|...||....|     |..|...|     |.:.:.|....
Human   346 RGFEKMPRQGCQLEQSSFLNPSFQWNVLNRSRRWKP-----PAVNQQFPQEDAGSVRRVLPGASD 405

  Fly   264 KI-VVNSFHGSSMLSTQQQEEKSRLLTQNGLTKSAATALETSLYASLYANAPQNSQPQFHSPRIS 327
            .: :.|:...:..:|.......:..|..|...:|   .:::|.:..  ..||   .|.|  |:..
Human   406 TLGLDNTVFCTKRISIHLLASHASGLNHNPACES---VIDSSAFGE--GKAP---GPPF--PQTL 460

  Fly   328 GGDHVASYVGVSLNKGAGHDNDRKHE-------DDPCAAIDDI--NYYDDSDSEEEYVGTPFFLE 383
            |..:||:.:. |:..|.. :.:|..|       |...::..|:  :..:..|:|||.|..   ||
Human   461 GIANVATRLS-SIQLGQS-EKERPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDG---LE 520

  Fly   384 -----EDNTETRQSKHTRLLPQKTPSKESVRTTDSEASVYFRP----EAILSP----SLFPHVPP 435
                 ::|.|.........|...:||:.....:.|...:..:|    |.::.|    ||||:|||
Human   521 DCCSRDENEEEEGDSECSSLSAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPP 585

  Fly   436 YLNFTSHADKGPPMPAALHRVLKWKLSPVMPKIVKRVVLNSGFRIIKNTTDWMAVWEKHMKSPGF 500
            .:.|.:..::...:|....::|:||:|.|.|.|||:.:..|.|:|.|...||:..|..|||||.|
Human   586 TIYFGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSF 650

  Fly   501 RTIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKSYIMPDDLESLRQVWPKNAS 565
            |:||.|||.||.||||:|||||.:||::.....:||||||.|..:|:|:|.|.:.||:.|  .:|
Human   651 RSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAW--ESS 713

  Fly   566 KLTKWIVKPPASARGTGIRIVNKWSQFPKDRPLVVQKYIERPLLINDNKFDMRLYVVLTSINPLR 630
            ...||||||||||||.||::::||||.||.|||:||:|:.:|.||:.:|||:|:||.:||.:|||
Human   714 SRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLR 778

  Fly   631 IYMYKDGLARFASVKYSSELSNLDERCMHLTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCL 695
            ||::.|||.||||.|||..:.:|..:.|||||||:||.:..|..|.|..|||||||.|::||:.|
Human   779 IYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALWNYL 843

  Fly   696 ENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYRQNVNFRYNCFELFGFDVLLDENLVPWLLEIN 760
            ..:|||:..:|..::::|:|.|:|.|..:..:.:..|...|:|.||||||::|||||.||:||:|
Human   844 SQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENLKPWVLEVN 908

  Fly   761 ISPSLHSELPLDLHVKGPLIQAVLNTALYQVPPKLNERQQADILEELNL---------TGPLCHD 816
            |||||||..|||:.:||.:|:.:||.|.:.:|      ...||:...:.         |.|  .|
Human   909 ISPSLHSSSPLDISIKGQMIRDLLNLAGFVLP------NAEDIISSPSSCSSSTTSLPTSP--GD 965

  Fly   817 K-RIFTTCLTAEEVRKHNQYTNRSIEFREEYVDTILDNLLPDDVRCLIVAEDELARCQPLERIFP 880
            | |:....:||::::|....|.:..:  :::..::||.|.|||||.|:..|||.:|....|||||
Human   966 KCRMAPEHVTAQKMKKAYYLTQKIPD--QDFYASVLDVLTPDDVRILVEMEDEFSRRGQFERIFP 1028

  Fly   881 TAGTHVYLRYVENARYYNRLLDAWETKYAKNREMGIALLSRYCRDKYHL-QVSDAAMEKEPNVAL 944
            :..:..|||:.|..||:|.|...||.||..|:..|:.||..:|...:|: .|||:|    |.|:.
Human  1029 SHISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSA----PVVSA 1089

  Fly   945 TEID--------------------------MLHVRKDEV-LDGATTLAILKPVVQEGCEVA 978
            ..::                          :|.:.||:| |:..:.....|...|..|||:
Human  1090 ASVEDSSFSGPSLLCLMSAAGVGLWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVS 1150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	153/293 (52%)
TTLL4	XP_016860876.1	TTL	654..946	CDD:397308	154/299 (52%)