DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4B and TTLL2

DIOPT Version :9

Sequence 1:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_114155.4	Gene:	TTLL2 / 83887	HGNCID:	21211	Length:	592	Species:	Homo sapiens

Alignment Length:	515	Identity:	154/515 - (29%)
Similarity:	247/515 - (47%)	Gaps:	79/515 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 SDSEEEYVG-----TPFFLEEDNTETRQSKHTRLLPQKTPSKESVRTTDSEASV---YFRPEAIL 425
            |.::.:.:|     ||.|.....:|   :.||    ::.|:....|..::..|:   ..||...|
Human     8 SSTQSQALGSLRTTTPAFTLNIPSE---ANHT----EQPPAGLGARLQEAGVSIPPRRGRPTPTL 65

  Fly   426 SPSLFPHVPPYLNFTSHADKGPPMPAALHRVLKWKLSPVMPKIVKRVVLNSGFRII----KNTTD 486
            .....||:        .|:..|  ..||.:.|.:::....|.:|:.|:|..|:...    :|..|
Human    66 EKKKKPHL--------MAEDEP--SGALLKPLVFRVDETTPAVVQSVLLERGWNKFDKQEQNAED 120

  Fly   487 WMAVWEKHMKSPGFR-----TIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKS 546
            |...|    ::..||     :::..|:.||.||:.::.|||.:.:.:.:..:.:|...:.|:..:
Human   121 WNLYW----RTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRRMYGTSLYQFIPLT 181

  Fly   547 YIMPDDLESL-------RQVWPKNASKLTKWIVKPPASARGTGIRIVNKWSQFPKDRPLVVQKYI 604
            ::||:|....       ||:.   .:|.:.||.||...:||.||.|.:.:..|..|...:|||||
Human   182 FVMPNDYTKFVAEYFQERQML---GTKHSYWICKPAELSRGRGILIFSDFKDFIFDDMYIVQKYI 243

  Fly   605 ERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVKYSSELSNLDERCMHLTNYSINKFS 669
            ..||||...|.|:|:||.:|...||.||:|::||.|||:.|:  :||||.....||||.||||..
Human   244 SNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLVRFATEKF--DLSNLQNNYAHLTNSSINKSG 306

  Fly   670 QNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYRQNVNF 734
            .:|.|.::... .|.||||...:|.|.:..|:...||..:..:||..|::        ...:|.|
Human   307 ASYEKIKEVIG-HGCKWTLSRFFSYLRSWDVDDLLLWKKIHRMVILTILA--------IAPSVPF 362

  Fly   735 RYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQAVLNTALYQVPPKLNERQ 799
            ..|||||||||:|:|:||.|||||:|.||:|..:...|:.||..|:..:::  |..:....||.:
Human   363 AANCFELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKRKLVHDIID--LIYLNGLRNEGR 425

  Fly   800 QADILEELN------------LTGPLC--HDKRIFTTCLTAEEVRKHNQYTNRSIEFREE 845
            :|......|            |..|.|  :|...||:.:..|:    :....:::..|.|
Human   426 EASNATHGNSNIDAAKSDRGGLDAPDCLPYDSLSFTSRMYNED----DSVVEKAVSVRPE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	111/301 (37%)
TTLL2	NP_114155.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		2/14 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..77		7/33 (21%)
		TTL	140..412	CDD:281171	108/285 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920