Protein Alignment TTLL4B and TTLL2

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_114155.4
• Gene: TTLL2 / 83887
• HGNCID: 21211
• Length: 592
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 154/515 - (29%)
• Similarity: 247/515 - (47%)
• Gaps: 79/515 - (15%)

  Fly   369 SDSEEEYVG-----TPFFLEEDNTETRQSKHTRLLPQKTPSKESVRTTDSEASV---YFRPEAIL 425
            |.::.:.:|     ||.|.....:|   :.||    ::.|:....|..::..|:   ..||...|
Human     8 SSTQSQALGSLRTTTPAFTLNIPSE---ANHT----EQPPAGLGARLQEAGVSIPPRRGRPTPTL 65

  Fly   426 SPSLFPHVPPYLNFTSHADKGPPMPAALHRVLKWKLSPVMPKIVKRVVLNSGFRII----KNTTD 486
            .....||:        .|:..|  ..||.:.|.:::....|.:|:.|:|..|:...    :|..|
Human    66 EKKKKPHL--------MAEDEP--SGALLKPLVFRVDETTPAVVQSVLLERGWNKFDKQEQNAED 120

  Fly   487 WMAVWEKHMKSPGFR-----TIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKS 546
            |...|    ::..||     :::..|:.||.||:.::.|||.:.:.:.:..:.:|...:.|:..:
Human   121 WNLYW----RTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRRMYGTSLYQFIPLT 181

  Fly   547 YIMPDDLESL-------RQVWPKNASKLTKWIVKPPASARGTGIRIVNKWSQFPKDRPLVVQKYI 604
            ::||:|....       ||:.   .:|.:.||.||...:||.||.|.:.:..|..|...:|||||
Human   182 FVMPNDYTKFVAEYFQERQML---GTKHSYWICKPAELSRGRGILIFSDFKDFIFDDMYIVQKYI 243

  Fly   605 ERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVKYSSELSNLDERCMHLTNYSINKFS 669
            ..||||...|.|:|:||.:|...||.||:|::||.|||:.|:  :||||.....||||.||||..
Human   244 SNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLVRFATEKF--DLSNLQNNYAHLTNSSINKSG 306

  Fly   670 QNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYRQNVNF 734
            .:|.|.::... .|.||||...:|.|.:..|:...||..:..:||..|::        ...:|.|
Human   307 ASYEKIKEVIG-HGCKWTLSRFFSYLRSWDVDDLLLWKKIHRMVILTILA--------IAPSVPF 362

  Fly   735 RYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQAVLNTALYQVPPKLNERQ 799
            ..|||||||||:|:|:||.|||||:|.||:|..:...|:.||..|:..:::  |..:....||.:
Human   363 AANCFELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKRKLVHDIID--LIYLNGLRNEGR 425

  Fly   800 QADILEELN------------LTGPLC--HDKRIFTTCLTAEEVRKHNQYTNRSIEFREE 845
            :|......|            |..|.|  :|...||:.:..|:    :....:::..|.|
Human   426 EASNATHGNSNIDAAKSDRGGLDAPDCLPYDSLSFTSRMYNED----DSVVEKAVSVRPE 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	110/300 (37%)
TTLL2	NP_114155.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		2/14 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..77		7/33 (21%)
		TTL	140..412	CDD:397308	108/285 (38%)