Protein Alignment TTLL4B and TTLL7

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_078962.4
• Gene: TTLL7 / 79739
• HGNCID: 26242
• Length: 887
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 162/585 - (27%)
• Similarity: 262/585 - (44%)
• Gaps: 98/585 - (16%)

  Fly   448 PMPAALHRVLKWKLSPVMPKIVKRV--------VLNSGFRIIKNTTDWMA-------------VW 491
            |.|..|:..|.:: |.:..|:.|:.        |..:.|.|::...|.|.             :|
Human    13 PSPLDLNTELPYQ-STMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDETSNLIW 76

  Fly   492 -EKHMKSPGFRTIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKK---EFGFMQKSYIMPDD 552
             :..::......::::|:.||.||...|.|||.:.|    ||.|..|.   ::.|:.:::|.|.:
Human    77 CDSAVQQEKISELQNYQRINHFPGMGEICRKDFLAR----NMTKMIKSRPLDYTFVPRTWIFPAE 137

  Fly   553 LESLRQVWPKNASKLTK---WIVKPPASARGTGIRIVNKWSQFPKDRPLVVQKYIERPLLINDNK 614
            .... |.:.|...|..|   :||||...|.|.||.::....:.|....|:||:|||:|.|:...|
Human   138 YTQF-QNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYK 201

  Fly   615 FDMRLYVVLTSINPLRIYMYKDGLARFASVKY-SSELSNLDERCMHLTNYSINKFSQNYAKNEDF 678
            ||:|:|:::||.:||:|::|.|||.|..:.|| ....|||.:..|||||||:||.::::.::|..
Human   202 FDLRIYILVTSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETE 266

  Fly   679 NACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYR-----QNVNFRYNC 738
            |  :|.|.:::.....|:....:..:.|:.:..||:|.::..|..:...||     |.......|
Human   267 N--KGSKRSIKWFTEFLQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVC 329

  Fly   739 FELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHVK-GPLIQAVLNTALYQVPPKLN-ERQQA 801
            ||:.|||:|||..|.|||||||.:||..::..:|..|| |.|:.|:....:.....:.| .:|:|
Human   330 FEVLGFDILLDRKLKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKA 394

  Fly   802 DILEELNLTGPLCHDKRIFTTCLTAEEVRKHNQYTNRSIEFREEYVDTILDNLLPDDVRCLIVAE 866
            :....|.....:   ||:.......|:.|  :|...|..|.:|...          .||..|..|
Human   395 EAQRRLYGQNSI---KRLLPGSSDWEQQR--HQLERRKEELKERLA----------QVRKQISRE 444

  Fly   867 D-ELARCQPLERIFPTAGTHVYLRYVENARYYNRLLDAWETKYAKNREMGIALLSRYCRDKYHLQ 930
            : |........||:|.....:.      .:|.|.|..|::|                     .|.
Human   445 EHENRHMGNYRRIYPPEDKALL------EKYENLLAVAFQT---------------------FLS 482

  Fly   931 VSDAAMEKE---PNVALTEIDMLHVRK-----DEVLDGATTLAI-LKPV--VQEGCEVAPIPDAC 984
            ...|:.::|   |...:.|.|:|.:.:     ||.|.|.||... .||:  :.|..|:...|..|
Human   483 GRAASFQRELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYC 547

  Fly   985  984
            Human   548  547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	106/307 (35%)
TTLL7	NP_078962.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		3/7 (43%)
		TTL	91..376	CDD:397308	105/291 (36%)
		YhaN	<384..>474	CDD:443752	22/110 (20%)
		c-MTBD region. /evidence=ECO:0000269|PubMed:25959773	388..450		17/76 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..621		9/29 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..676