DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4B and Ttll11

DIOPT Version :9

Sequence 1:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_084050.1	Gene:	Ttll11 / 74410	MGIID:	1921660	Length:	727	Species:	Mus musculus

Alignment Length:	714	Identity:	181/714 - (25%)
Similarity:	299/714 - (41%)	Gaps:	167/714 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 SAATALETSLYASLYANAPQNSQPQFHSPRISGGDHVASYVGVSLNKGAGHDNDR-KHEDDPCAA 359
            :||||..|.       :.|..::.|                 ..::.||..|.:| :.|:.|
Mouse    22 AAATAAATE-------SLPAETEKQ-----------------QGVDAGAAGDPERLELEEQP--- 59

  Fly   360 IDDINYYDDSDSEEEYVGTPFFLEEDNTETRQSKHTRLLPQKTP---SKESVRTTD--------S 413
             .|:.          .:.||  ......|..:::..|.||...|   .:.:.|...        |
Mouse    60 -KDVG----------RIPTP--TRRHAPEEGEARVVRRLPPALPLAQPRPAARALSQLVKARGRS 111

  Fly   414 EASVYFRPEAILSPSLFPHVPPYLNFTSHADKGPPMPAALH---RVLKWKLSPVMPKIVKRVVLN 475
            .:.||.|....:.|           .|..:.|......||.   |.|:||..|...::...:.
Mouse   112 RSRVYRRSAGSMRP-----------VTVDSSKARTSLDALKISLRQLRWKEFPFGRRLPCDIY-- 163

  Fly   476 SGFRIIKNTTDWMAVWEKHMKSPGFR--TIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKK 538
                       |..|        .||  .|.|.| .|..||...:.||.|:.|:: ..|:....:
Mouse   164 -----------WHGV--------SFRDSDILSGQ-VNKFPGMTEMVRKVTLSRAL-RIMQNLFPE 207

  Fly   539 EFGFMQKSYIMPDDLE----SLRQVWPKNASKLTKWIVKPPASARGTGIRIVNKWSQFPKD---- 595
            |:.|..:|:|:|::.:    .::.|...:.|....:||||.:..:|.||.::..    |.|
Mouse   208 EYNFYPRSWILPEEFQLFVSQVQTVKEGDPSWKPTFIVKPDSGCQGDGIYLIKD----PCDGRLT 268

  Fly   596 -----RPLVVQKYIERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVKYSS-ELSNLD 654
                 ||.|||:||.:||||:..|||:||||:|.|::||.||:.||||:||.:..|.. ...||.
Mouse   269 GTLHNRPAVVQEYIRKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPNPQNLH 333

  Fly   655 ERCMHLTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVS 719
            ...|||||||:|..|..:..::  :|..|.|.|..|:...|.::||:.|::|:.:.:||||.:::
Mouse   334 HVFMHLTNYSLNIHSGKFVHSD--SASTGSKRTFSSILCRLSSKGVDIKKVWSDIISLVIKTVIA 396

  Fly   720 GESGLNRMYRQNVNFRY---NCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQ 781
            ....|...|:.::....   .||::.|||:||.:||.|.|||:|.:||:..|...:
Mouse   397 LTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPMLLEVNANPSMRIEHEYE--------- 452

  Fly   782 AVLNTALYQVPPKL--NERQQADILEELNLTGPLCHDKRIFTTCLTAEEVRKHN--QYTNRSIEF 842
              |:..:::..|.|  .|.:.|.|.:.|.|..||...|.|....:..:  |||.  ..::|...:
Mouse   453 --LSPGVFENIPSLVDEEVKVAVIRDTLRLMDPLKKKKEIHFPDIYMD--RKHRIPPVSDRMSSW 513

  Fly   843 REEYVDTILDNLLPDDVRCLIVAEDELARCQP-----------------LERIFPT-AGTHVYLR 889
            :.:  .:.|..:....:.....::::| .|.|                 |:::||. |....|||
Mouse   514 KHK--GSSLSIVRSQQMEKSFTSKEDL-NCDPTGGDSEPNPEAHLPSICLKQVFPKYAKQFNYLR 575

  Fly   890 YVEN-ARYYNRLLDAWETKYAKNREMGIALLSRYCRDKYHLQVSDAAMEKEPNVALTEIDMLHV 952
            .|:. |..:.|.|....|  .|....|.....|.|:      :|.:::      ::..:|:|::
Mouse   576 LVDRMANLFIRFLGIKGT--MKLGPTGFRTFIRNCK------LSSSSL------SMAAVDILYI 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	105/313 (34%)
Ttll11	NP_084050.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		20/105 (19%)
		ATP-grasp_4	178..445	CDD:302634	98/274 (36%)
		c-MTBD region. /evidence=ECO:0000250\|UniProtKB:Q8NHH1	464..566		20/106 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	530..551		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920