Protein Alignment TTLL4B and Ttll4

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_001014974.1
• Gene: Ttll4 / 67534
• MGIID: 1914784
• Length: 1193
• Species: Mus musculus
• Alignment Length: 746
• Identity: 280/746 - (37%)
• Similarity: 406/746 - (54%)
• Gaps: 94/746 - (12%)

  Fly   209 KRAREEAFAKHTAGNSAANGNGPKRSAHSPPI----QAKVPPSNMSCPSTQTLKPSPPSKIVVNS 269
            ||......|.|..|.:.:...|   ||..|.:    :|.||||        :|:|...:::....
Mouse   412 KRISIHLLASHVHGLNPSPACG---SAVDPQVLGEDRAPVPPS--------SLQPLGVAEVATRL 465

  Fly   270 FHGSSMLSTQQQEEKSRLLTQNGLTKSAATALETSLYASLYANAPQNSQPQFHSPRISGGDHVAS 334
               ||:...|..:|.......|..||...:|.:..         |...:|:.....:..|
Mouse   466 ---SSVHLDQPGKEPEEAKDLNSCTKGGGSATDLQ---------PNQVEPEDTEDELGDG----- 513

  Fly   335 YVGVSLNKGAGHD-NDRKHEDDPCAAIDDINYYDDSDSEEEYVGTPFFLEEDNTETRQSKHTRLL 398
                 |.....|| |:.:..|..|:::..:       |..|.|.    |...|.       ..|:
Mouse   514 -----LEDSCSHDENEEEEGDSECSSLSVV-------SPSESVA----LISRNC-------VDLM 555

  Fly   399 PQKTPSKESVRTTDSEASVYFRPEAILSPSLFPHVPPYLNFTSHADKGPPMPAALHRVLKWKLSP 463
            .:..|:.|.|          .||..|.  ||||:|.|.:.|.:..::...:|....|:|:||:|.
Mouse   556 SKSLPNHEKV----------VRPALIY--SLFPNVTPTIYFGTRDERVEKLPWEQRRLLRWKMST 608

  Fly   464 VMPKIVKRVVLNSGFRIIKNTTDWMAVWEKHMKSPGFRTIRSHQKYNHIPGSFRIGRKDTMWRSI 528
            |.|.|||:.:..|.|:|.|...||:..|..||||||||:||.|||.||.||||:|||||.:||::
Mouse   609 VTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPGFRSIREHQKLNHFPGSFQIGRKDRLWRNL 673

  Fly   529 YNNMKKFGKKEFGFMQKSYIMPDDLESLRQVWPKNASKLTKWIVKPPASARGTGIRIVNKWSQFP 593
            .....:||||||.|..:|:|:|.|.:.||:.|  .:|...||||||||||||.||::::||||.|
Mouse   674 SRMQSRFGKKEFSFFPQSFILPQDSKLLRKAW--ESSSRQKWIVKPPASARGIGIQVIHKWSQLP 736

  Fly   594 KDRPLVVQKYIERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVKYSSELSNLDERCM 658
            |.|||:||:|:.:|.||:.:|||:|:||.:||.:|||||::.|||.||||.|||..:.:|..:.|
Mouse   737 KRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLSNKFM 801

  Fly   659 HLTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESG 723
            ||||||:||.:..|..|.|..|||||||.|::||:.|..:|:|:..:|..::::|:|.|:|.|..
Mouse   802 HLTNYSVNKKNTEYQANADETACQGHKWALKALWNYLSQKGINSDAIWEKIKDVVVKTIISSEPY 866

  Fly   724 LNRMYRQNVNFRYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQAVLNTAL 788
            :..:.:..|...|:|.||||||::|||||.||:||:||||||||..|||:.:||.:|:.:||.|.
Mouse   867 VTNLLKLYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSNSPLDISIKGQMIRDLLNLAG 931

  Fly   789 YQVPPKLNERQQADILEELNL------------TGPLCHDK-RIFTTCLTAEEVRKHNQYTNRSI 840
            :.:|      ...||:...:.            :.|  .|| ::.....||::::|....|.:..
Mouse   932 FVLP------NMEDIISSSSSPSSSSGSSTSLPSSP--RDKCQMTPEHFTAQKMKKAYYLTQKIP 988

  Fly   841 EFREEYVDTILDNLLPDDVRCLIVAEDELARCQPLERIFPTAGTHVYLRYVENARYYNRLLDAWE 905
            :  :::..::||.|.|||||.|:..|||.:|....|||||:..:..|||:.|..||:|.|...||
Mouse   989 D--QDFYASVLDVLTPDDVRVLVEMEDEFSRRGQFERIFPSRISSRYLRFFEQPRYFNILTTQWE 1051

  Fly   906 TKYAKNREMGIALLSRYCRDKYHLQ-VSDAA 935
            .||..|:..|:.||..:|...:|.. |||:|
Mouse  1052 QKYHGNKLKGVDLLRNWCYKGFHTGIVSDSA 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	152/293 (52%)
Ttll4	NP_001014974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	468..535		15/85 (18%)
		TTL	649..941	CDD:397308	153/299 (51%)
		c-MTBD region. /evidence=ECO:0000250|UniProtKB:Q14679	913..1027		36/123 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	943..966		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1092..1193