Protein Alignment TTLL4B and TTLL13

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_001382946.1
• Gene: TTLL13 / 440307
• HGNCID: 32484
• Length: 751
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 161/571 - (28%)
• Similarity: 247/571 - (43%)
• Gaps: 98/571 - (17%)

  Fly   370 DSEEEYVGTPFFLEEDNTETRQSKHTRLLPQKTPSKESVRTTDSEASVYFRPEAILSPSLFPHVP 434
            :|||:||        :..|:.:.....:......|::::...|.:|.....|..|::..:...|.
Human    10 ESEEDYV--------EEKESEKCVKEGVTNPSNSSQQALLKADYKALKNGVPSPIMATKIPKKVI 66

  Fly   435 PYLNFTSHADKGPPMPAALHRVLKWKLSPVMPKIVKRVVLNSGFRIIKNTTDWMAVW-------E 492
            ..:: |...:.|........|.|...|:....:.|:|.....|.:.:....:|...|       |
Human    67 APVD-TGDLEAGRRKRRRKRRSLAINLTNCKYESVRRAAQMCGLKEVGEDEEWTLYWTDCAVSLE 130

  Fly   493 KHMKSPGFRTIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKSYIMPDDLESLR 557
            :.|....|      ||.||.||...|.|||.:.|:: |.|.|....|:....:::.:|.|....:
Human   131 RVMDMKRF------QKINHFPGMTEICRKDLLARNL-NRMYKLYPSEYNIFPRTWCLPADYGDFQ 188

  Fly   558 QVWPKNASKLTKWIVKPPASARGTGIRIVNKWSQFPKDRPLVVQKYIERPLLINDNKFDMRLYVV 622
            ....:.  |...:|.||.:..:|.||.|.....:......::.|:||.:||||:..|||||:||:
Human   189 SYGRQR--KARTYICKPDSGCQGRGIFITRNPREIKPGEHMICQQYISKPLLIDGFKFDMRVYVL 251

  Fly   623 LTSINPLRIYMYKDGLARFASVKY-SSELSNLDERCMHLTNYSINKFSQNYAKNEDFNACQGHKW 686
            :||.:||||:.|::||||||:..| ....:|||..|||||||:|||.::|:.:    :...|.|.
Human   252 ITSCDPLRIFTYEEGLARFATTPYMEPSHNNLDNVCMHLTNYAINKHNENFVR----DGAVGSKR 312

  Fly   687 TLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYRQNVNFRYN-----CFELFGFDV 746
            .|.:|...|:....|...||..:.:::||.|:|..|.|...||.......|     |||:.|||:
Human   313 KLSTLNIWLQEHSYNPGELWGDIEDIIIKTIISAHSVLRHNYRTCFPQYLNGGTCACFEILGFDI 377

  Fly   747 LLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQAVLNTALYQVPPKLNERQQADILEELNLTG 811
            |||..|.|||||:|.|||..::..||..||..|:                    .|.:..:||.|
Human   378 LLDHKLKPWLLEVNHSPSFTTDSCLDQEVKDALL--------------------CDAMTLVNLRG 422

  Fly   812 PLC-------HDK-----RIFTTCLTAEEVRKH-NQYTNRSIEFREEYVDTILDNLLPDDVRCLI 863
              |       .||     |:|.......|.||. .:.::.::..:|.|.|:.|..
Human   423 --CDKRKVMEEDKRRVKERLFQCYRQPRESRKEKTESSHVAMLDQERYEDSHLGK---------- 475

  Fly   864 VAEDELARCQPLERIFPTAGTHVYLRYVE-NARYYNRLLDAWETKYAKNRE 913
                       ..||:|...|..|.|:.: |...:.      ||..:|.||
Human   476 -----------YRRIYPGPDTEKYARFFKHNGSLFQ------ETAASKARE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	108/299 (36%)
TTLL13	NP_001382946.1	TTL	133..427	CDD:397308	115/328 (35%)
		HEC1	<425..615	CDD:444066	23/112 (21%)