DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4B and TTLL15

DIOPT Version :9

Sequence 1:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	NP_650021.1	Gene:	TTLL15 / 41300	FlyBaseID:	FBgn0037838	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	139/598 - (23%)
Similarity:	235/598 - (39%)	Gaps:	139/598 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 DINYYDDSDSEEEYVGTPFFLEEDNTETRQSKHTRLLPQKTPSKESVRTTDSEASVYFRPEAILS 426
            |.:..:::.:::|..|.....||..   :.|....|||.......:|.|.             :.
  Fly     2 DASVVENAPNQKEVDGKMATTEESE---KPSNSIGLLPIMIFLAATVATA-------------VV 50

  Fly   427 PSLFPH---VPPYLNFTSHAD--KGPPMPAALHRVLKWKLSPVMPKIVKRV-VLNS-GFRIIKNT 484
            ..:.||   |.|:....|.||  :.||..|...|      ||....:|..| ||:. |::.:...
  Fly    51 VEVLPHASRVFPWKLADSSADQLQPPPTYAIFGR------SPTEEHLVHVVNVLHKFGYKRVGVN 109

  Fly   485 TDWMAVWEKHMKSPGFRTIRS---HQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKS 546
            ..|..:|........|..:::   ||..||.||...:..|..:..:           :..|:.::
  Fly   110 DSWNLLWAHDYPFLSFANLKNLGQHQVVNHYPGCGYLTNKVDLCTT-----------QLPFLPRA 163

  Fly   547 YIMPDDLESLRQVWPKNASKLTKWIVKPPASARGTGIRIVNKWSQFPKD-----RPLVVQKYIER 606
            :.:|.:.|.......:|...|   .|:.....|...:|.       |.|     ....||::::|
  Fly   164 FRLPAEREEFLDYARENPQAL---FVQKHNEHRHIKVRA-------PADIAFGSNDSFVQEFVQR 218

  Fly   607 PLLINDNKFDMRLYVVLTSINPLRIYMYK-DGLARFASVKYSS-ELSNLDERCM---HLTNYSIN 666
            |.|::.:|||:.:|||:||:||||:|:|. |.|.|:..|||.. :..|:|:..:   :|..:.:.
  Fly   219 PYLVDGHKFDIGVYVVITSVNPLRVYIYTGDVLFRYCPVKYHPFDAENVDKYIVGDDYLPTWEVP 283

  Fly   667 KFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGES---GLNRMY 728
            ...:.|      |...|...|:...:  :.::|.:..::|..:.::|...|.:.|.   .:.|.|
  Fly   284 SLRKYY------NRFGGSMRTVFEAY--VRDQGKDPAQIWPQVEHIVRTTIAAKEKDIVNILRSY 340

  Fly   729 RQNVNFRYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQAVLNTALY-QVP 792
            |     .:|.|:|..||:.:||:|..:|:|.|:||:|.|     .|.|.       |:.|| ||
  Fly   341 R-----THNFFDLMRFDLFIDEDLKVFLMEANMSPNLSS-----AHFKP-------NSLLYEQV- 387

  Fly   793 PKLNERQQADILEELNLTG--PLCH---------------DKRIFT---TCLTAEEVRKHNQYTN 837
                      :....||.|  ||..               ||.:.|   .|...:..:..|
  Fly   388 ----------LYSVFNLVGIRPLTSTSGALLGESSEMITTDKNLSTDLNKCAAHDCDKSCN---- 438

  Fly   838 RSIEFREEYVDTILDNLLPDDVRCLIVAEDELARCQPLERIFPTAGTHVYLRY---VENARYYNR 899
                  :|..|..|..|...:.:.|..|..|......::||||.. ....:|:   .|.|....:
  Fly   439 ------KEECDLCLQCLSGSEYKMLQQAHQEHLHRVDMKRIFPKP-IRDPMRFDVMAETANMSKK 496

  Fly   900 LLDAWETKYAKNR 912
              :||.|::..|:
  Fly   497 --NAWMTRWFHNK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	79/311 (25%)
TTLL15	NP_650021.1	TTL	134..395	CDD:281171	80/317 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2156
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740