DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4B and Ttll7

DIOPT Version :9

Sequence 1:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	XP_038959801.1	Gene:	Ttll7 / 310982	RGDID:	1566117	Length:	886	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	153/546 - (28%)
Similarity:	250/546 - (45%)	Gaps:	83/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 HRVLKWKLSPVMPK-IVKRVVLNSGFRIIKNTTDWMA-------------VW-EKHMKSPGFRTI 503
            |..:|.|:.....| |:...|..:.|.|::...|.|.             :| :..::......:
  Rat    25 HCTMKRKVRKKKKKGIITANVAGTKFEIVRLVIDEMGFIKTPDEDETSNLIWCDAAVQQEKITDL 89

  Fly   504 RSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKK---EFGFMQKSYIMPDDLESLRQVWPKNAS 565
            :::|:.||.||...|.|||.:.|    ||.|..|.   ::.|:.:::|.|.:.... |.:.|...
  Rat    90 QNYQRINHFPGMGEICRKDFLAR----NMTKMIKSRPMDYTFVPRTWIFPSEYTQF-QNYVKELK 149

  Fly   566 KLTK---WIVKPPASARGTGIRIVNKWSQFPKDRPLVVQKYIERPLLINDNKFDMRLYVVLTSIN 627
            |..|   :|:||...|.|.||.::....:.|....|:||:|||:|.|:...|||:|:|:::||.:
  Rat   150 KKRKQKTFIIKPANGAMGHGISLIRNGDKIPSQDHLIVQEYIEKPFLMEGYKFDLRIYILVTSCD 214

  Fly   628 PLRIYMYKDGLARFASVKY-SSELSNLDERCMHLTNYSINKFSQNYAKNEDFNACQGHKWTLQSL 691
            ||:|::|.|||.|..:.|| ....|||.:..|||||||:||.::.:.:||..:  :|.|.:::..
  Rat   215 PLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNERFERNETED--KGSKRSIKWF 277

  Fly   692 WSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYR-----QNVNFRYNCFELFGFDVLLDEN 751
            ...|:....:..:.|:.:..||:|.::..|..:...||     |.......|||:.|||:|||..
  Rat   278 TEFLQANQHDVTKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRK 342

  Fly   752 LVPWLLEINISPSLHSELPLDLHVK-GPLIQA--VLNTALYQVPPKLNERQQADILEELNLTGPL 813
            |.|||||||.:||..::..:|..|| |.|:.|  :||.........| .:|:|:....|....|:
  Rat   343 LKPWLLEINRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRKNL-AKQKAEAQRRLYGQNPI 406

  Fly   814 CHDKRIFTTCLTAEEVRKHNQYTNRSIEFREEYVDTILDNLLPDDVRCLIVAED-ELARCQPLER 877
               :|:.......|:.|  :|...|..|.:|..:          .||..|..|: |........|
  Rat   407 ---RRLSPGSSDWEQQR--HQLERRKEELKERLL----------QVRKQISQEEHENRHMGNYRR 456

  Fly   878 IFPTAGTHVYLRYVENARYYNRLLDAWETKYAKNREMGIALLSRYCRDKYHLQVSDAAMEKEPNV 942
            |:|.....:.      .:|...|..|::| :...|           ...:|.::::      |..
  Rat   457 IYPPEDKTLL------EKYEGLLAVAFQT-FLSGR-----------ATSFHREMNN------PLK 497

  Fly   943 ALTEIDMLHVRK-----DEVLDGATT 963
            .:.|.|:|.:.:     ||.|.|.||
  Rat   498 KMREEDLLDLLEQCEIDDEKLMGKTT 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	107/309 (35%)
Ttll7	XP_038959801.1	TTL	91..376	CDD:397308	104/291 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920