DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TTLL4B and TTLL6

DIOPT Version :10

Sequence 1:NP_722946.1 Gene:TTLL4B / 33609 FlyBaseID:FBgn0031574 Length:989 Species:Drosophila melanogaster
Sequence 2:NP_001124390.1 Gene:TTLL6 / 284076 HGNCID:26664 Length:891 Species:Homo sapiens


Alignment Length:620 Identity:180/620 - (29%)
Similarity:284/620 - (45%) Gaps:75/620 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 RQSKHTRLLPQKTPSKESVRTTDSEA---SVYFRPEAILSPSLFPHVPPYLNFTSHADKGPPMPA 451
            |.|...|.:|| .|:.||....:||.   |....|:..::.:.....|...|...:|.:......
Human    41 RASSQAREMPQ-CPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKR 104

  Fly   452 ALHRVLKWKLSPVMPKIVKRVVLNSGFRIIKNTTDWMAVWEKHMKS-PGFRTIRSHQKYNHIPGS 515
            ...| |...||....:.|:|.....|||......||...|..:..| .....::|:||.||.||.
Human   105 KKKR-LVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGM 168

  Fly   516 FRIGRKDTMWRSIYNNMKKFGKKEFGFMQKSYIMPDDLESLRQVWPKNASKLTKWIVKPPASARG 580
            ..|.|||.:.|::...:|.| .|:|.|..:::.:|.|...| |.:.::....| :|.||.:..:|
Human   169 SEICRKDLLARNMSRMLKMF-PKDFRFFPRTWCLPADWGDL-QTYSRSRKNKT-YICKPDSGCQG 230

  Fly   581 TGIRIVNKWSQFPKDRPLVVQKYIERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVK 645
            .||.|.....:......::.|.||.:|.:|:..|||:|:||::||.:||||::|.:||||||:..
Human   231 KGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTS 295

  Fly   646 YSSELS-NLDERCMHLTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATL 709
            ||...: |||:.|||||||||||.|.|:::    :|..|.|..|.:..:.||:...|.:::|..:
Human   296 YSRPCTDNLDDICMHLTNYSINKHSSNFSR----DAHSGSKRKLSTFSAYLEDHSYNVEQIWRDI 356

  Fly   710 RNLVIKGIVSGESGLNRMYR---QNVNFRYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPL 771
            .:::||.::|....:...|.   .|......|||:.|||:|||..|.|||||:|.|||..::..|
Human   357 EDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRL 421

  Fly   772 DLHVKGPLIQAVLNTALYQVPPKLNERQQADILEELNLTGPLCHDKRIFTTCLTAEEVRKHNQYT 836
            |..||..|        ||            |.|..:||..  |..|::.      ||.|:..|:.
Human   422 DKEVKDGL--------LY------------DTLVLINLES--CDKKKVL------EEERQRGQFL 458

  Fly   837 NR--SIEFREEYVDTILDNLLPDDVRCLIVAEDEL---ARCQPLERIFPTAGTHVYLRYVE--NA 894
            .:  |.|.|.|..         ...|.:.:.:.|.   ..|.....|:|:..:..|.::.:  |:
Human   459 QQCCSREMRIEEA---------KGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNS 514

  Fly   895 RYYNRLLDAWETKYAKN--REMGIALLSRYCRDKYHLQVSDAAMEKEPNVALTEIDMLHVR---- 953
            .:.|.:......:||:.  :|:      |..|:|...|:. ..:|.:...|..::....:|    
Human   515 LFQNTVASRAREEYARQLIQEL------RLKREKKPFQMK-KKVEMQGESAGEQVRKKGMRGWQQ 572

  Fly   954 KDEVLDGATTLAILKPVVQEGCEVAPIPDACIEIK 988
            |.:..|.|.|.| .|..:|....|:..||..:.::
Human   573 KQQQKDKAATQA-SKQYIQPLTLVSYTPDLLLSVR 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TTLL4BNP_722946.1 TTL 504..798 CDD:397308 110/297 (37%)
TTLL6NP_001124390.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..106 13/62 (21%)
TTL 154..441 CDD:397308 114/313 (36%)
c-MTBD region. /evidence=ECO:0000269|PubMed:25959773 420..499 25/115 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 546..584 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 607..636 180/620 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..711
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..820
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.