Protein Alignment TTLL4B and TTLL3

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: NP_001021100.3
• Gene: TTLL3 / 26140
• HGNCID: 24483
• Length: 915
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 146/679 - (21%)
• Similarity: 236/679 - (34%)
• Gaps: 191/679 - (28%)

  Fly   174 PNSSTPKVAAT----PSNVPVVANSVLQSEPYKKVQMLLKRAREEAFAKHTAGNSAANGNGPKRS 234
            |.:|.|....:    |..:|....:..|||                 ..|..|...|....|.|.
Human    45 PRTSFPSARRSEFRPPRRLPWAGPASAQSE-----------------EGHAGGRCQAGSPAPARR 92

  Fly   235 AHSPPIQAKVPPSN---------MSCPSTQTLKPSPPSKIVVNSFHGSSMLSTQQQEEKSRLLTQ 290
            . |...:..||.::         :..|.|..|.|||.....| .:.|||..|...:...:::..:
Human    93 L-SGAFKTLVPGTHAQGASDTHPLGPPHTPVLDPSPQDGFPV-LWRGSSKASHMNRLRNAKIYVE 155

  Fly   291 NGLTKSAATALETSLY---------------ASLYANAPQNSQPQFHSPRISGGDHVASYVGVSL 340
            ..:.:.....:: ..|               ..::.:.|....||......:.||.       ..
Human   156 RAVKQKKIFTIQ-GCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGDS-------DT 212

  Fly   341 NKGAGHDNDRKHEDDPCAAIDDINYYDDSDSEEEYV--------GTPFFLE-------------- 383
            .:....|.|.:.:.......||:..:||.|.....:        ..|:|.|
Human   213 TEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDANSFFPRCYCLG 277

  Fly   384 ---------EDNTETRQSKHTRLLPQKTPSKESVRTTDSEASVYFRPE------AILSPSLFPHV 433
                     ||...|......:|:.:.......::..:.|||...:|:      .::||......
Human   278 AEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQPKKQEKNPVLVSPEFVDEA 342

  Fly   434 ----PPYLNFTSHADKGPPMPAALHRVLKWKLSPVMPKIVKRVVLNSGFRIIKNTTDWMAVWEKH 494
                ..||:..:|.|....:.|.|:      |:|                     ..|....:::
Human   343 LCACEEYLSNLAHMDIDKDLEAPLY------LTP---------------------EGWSLFLQRY 380

  Fly   495 MKSPGFRTIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKKFGKKEFGFMQKSYIMPD-DLESLRQ 558
                 ::.:....:..|:         ||          :..:.|....|...::|. |:|..|.
Human   381 -----YQVVHEGAELRHL---------DT----------QVQRCEDILQQLQAVVPQIDMEGDRN 421

  Fly   559 VWPKNASKLTKWIVKPPASARGTGI----------RIVNKWSQFPKDRPLVVQKYIERPLLINDN 613
            :          |||||.|.:||.||          ::||......||...||||||||||||...
Human   422 I----------WIVKPGAKSRGRGIMCMDHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGT 476

  Fly   614 KFDMRLYVVLTSINPLRIYMYKDGLARFASVKYSSELSNLDERCMHLTNYSINKFSQNYAKNEDF 678
            |||:|.:.::|..|||.::.|:|...||::..:|  |.||| ..:||.|.||.|..:
Human   477 KFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFS--LKNLD-NSVHLCNNSIQKHLE-------- 530

  Fly   679 NACQGH-------KWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMYRQNVNFRY 736
            |:|..|       .|:.|...:.|:..|  ....|:|   :::.|:........:..:..|..|.
Human   531 NSCHRHPLLPPDNMWSSQRFQAHLQEMG--APNAWST---IIVPGMKDAVIHALQTSQDTVQCRK 590

  Fly   737 NCFELFGFDVLLDENLVPWLLEINISPSL 765
            ..|||:|.|.:..|:..|||:|||.||::
Human   591 ASFELYGADFVFGEDFQPWLIEINASPTM 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	84/280 (30%)
TTLL3	NP_001021100.3	TTL	356..648	CDD:397308	90/341 (26%)