Protein Alignment TTLL4B and TTLL10

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: XP_047272797.1
• Gene: TTLL10 / 254173
• HGNCID: 26693
• Length: 799
• Species: Homo sapiens
• Alignment Length: 842
• Identity: 177/842 - (21%)
• Similarity: 282/842 - (33%)
• Gaps: 258/842 - (30%)

  Fly    64 KMVMCKKLAHHNHVPASSHHLQPHLAAPNRNHGRIVQSSTPQHRSSAG-GGSAAGATASDSVSAR 127
            |.:.|.  ::...|...|.||      .:|:.||    :.|..:|.:| ||.|.....:::.|
Human     3 KSLFCS--SYRGAVSCRSFHL------TSRHPGR----AQPHLKSRSGQGGHARQRQGAETAS-- 53

  Fly   128 YSPPGQKQRSPPSPRKRLTPEKVANLGGGGGG---SKVGAQRIIIRGTPPNSSTPKVAATPSNVP 189
             .|.|.:..|  ..|....|...|...|.|..   .:||.....|:...|.      ||..|:..
Human    54 -PPHGARPHS--CHRDGSQPHAEAQAHGPGRRPFLGRVGLTACSIQALGPR------AARRSHRR 109

  Fly   190 VVANSVLQ----SEPYKKVQMLLKRAREEAFAK--HTAGNSAANGNGPKRSAHSPPIQAK----- 243
            |.|.|.||    ..|         |..:.:..:  |..|.......|.||... |.||.:
Human   110 VRAASSLQGPRPGTP---------RPMDHSCTRFIHRRGPPTRTRAGFKRGKR-PRIQQRPRARV 164

  Fly   244 ---VPPSNM-SCPSTQTLKPSP---PSKIVVNSFHGSSMLSTQQQEEKSRLLTQNGLTKSAATAL 301
               :|.|.: ..|::|   |.|   |....|...|...|.|:|::          ||
Human   165 SGTIPASRLHPAPASQ---PGPCPAPGHCPVGPAHERPMGSSQEE----------GL-------- 208

  Fly   302 ETSLYASLYANAPQNSQPQFHS-----PRISGGDHVASYVGVS--LNKGAGHDNDRKHEDDPCAA 359
                       ..|.|||...:     |.:.|.:..::..|..  ||.....|:|..:...|.||
Human   209 -----------RCQPSQPDHDADGHCGPDLEGAERASATPGPPGLLNSHRPADSDDTNAAGPSAA 262

  Fly   360 -IDDINYYDDSDSEEEYVGTPFF-LEEDNTETRQSKHTRLLPQKTPSKESVRTTDSEASVYFRPE 422
             ::.:.......|.......||| :...|..|..|.:.:       ||...|..||....|
Human   263 LLEGLLLGGGKPSPHSTRPGPFFYIGGSNGATIISSYCK-------SKGWQRIHDSRRDDY---- 316

  Fly   423 AILSPSLFPHVPPYLNFTSHADKGPPMPAALHRVLKW----------------KLSPVMPK---I 468
                                             .|||                :|...:|.   :
Human   317 ---------------------------------TLKWCEVKSRDSYGSFREGEQLLYQLPNNKLL 348

  Fly   469 VKRVVLNSGFRIIKNTTDWMAVWEKHMKSPGFRTIRSHQKYNHIPGSFRI---------GRKDTM 524
            ..::.|.|..|                     ...|:..|.:.:||..:.         ..:|..
Human   349 TTKIGLLSTLR---------------------GRARAMSKASKVPGGVQARLEKDAAAPALEDLP 392

  Fly   525 WRSI-YNNMKKFGKKEFGFMQKSYIMPDDLESLRQVWPKNASKLTKWIVKPPASARGTGIRIVNK 588
            |.|. |...::..:.| .|..::|.:  ||:..|:.:.....:...||.||.||.:|.||.::..
Human   393 WTSPGYLRPQRVLRME-EFFPETYRL--DLKHEREAFFTLFDETQIWICKPTASNQGKGIFLLRN 454

  Fly   589 WSQFP---------KDRPL------------VVQKYIERPLLINDNKFDMRLYVVLTSINPLRIY 632
            ..:..         :|.|:            |||:||:.|||::..|||:|.|:::....|..|:
Human   455 QEEVAALQAKTRSMEDDPIHHKTPFRGPQARVVQRYIQNPLLVDGRKFDVRSYLLIACTTPYMIF 519

  Fly   633 MYKDGLARFASVKYSSELSNLDERCMHLTNYSINKFSQNYAKNEDFNACQGHKWTLQSL------ 691
             :..|.||.....|....|:|..   ||||..:.|.|..|...::...     |:::.|
Human   520 -FGHGYARLTLSLYDPHSSDLGG---HLTNQFMQKKSPLYMLLKEHTV-----WSMEHLNRYISD 575

  Fly   692 --WSCLENRGVNTKRLWATLRNLVIKGIVSGESGLNRMY----------RQNVNFRYNCFELFGF 744
              |..   ||:....::.||:              .||.          :..::.:...|:|.|.
Human   576 TFWKA---RGLAKDWVFTTLK--------------KRMQQIMAHCFLAAKPKLDCKLGYFDLIGC 623

  Fly   745 DVLLDENLVPWLLEINISPSLHSELPLDLHVKGPLIQAVLNTALYQVPPKLNERQQADILEE 806
            |.|:|:|...||||:|.:|:||:...:...|...::...|:..|......|..::...:|.:
Human   624 DFLIDDNFKVWLLEMNSNPALHTNCEVLKEVIPGVVIETLDLVLETFRKSLRGQKMLPLLSQ 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	81/342 (24%)
TTLL10	XP_047272797.1	PHA03247	<54..283	CDD:223021	59/278 (21%)
		CPSase_L_D2	408..674	CDD:473076	72/294 (24%)