Protein Alignment TTLL4B and Ttll8

DIOPT Version :10

• Sequence 1: NP_722946.1
• Gene: TTLL4B / 33609
• FlyBaseID: FBgn0031574
• Length: 989
• Species: Drosophila melanogaster
• Sequence 2: XP_006521018.1
• Gene: Ttll8 / 239591
• MGIID: 1922902
• Length: 928
• Species: Mus musculus
• Alignment Length: 845
• Identity: 174/845 - (20%)
• Similarity: 300/845 - (35%)
• Gaps: 266/845 - (31%)

  Fly   139 PSPRK--RLTPEKVANLGGGGG-----------------GSKVG-----AQRIIIRGTPPNSSTP 179
            ||||.  ||.|....:|....|                 .|:|.     .|||.:..:||....|
Mouse     8 PSPRSRPRLHPRPSRSLDRNMGLDLEPKLSVSASNCVRTASRVSPVLRCCQRIPLSRSPPQPLPP 72

  Fly   180 KVAATPSNVPVVANSVLQSEP-YKKVQ--MLLKRAREEAFA-KHTAGNSAANGNGPKRSAHSPPI 240
            ....:|:  |.|...:.:.:| |::.:  ..:.:||..|.: :.|.|.||      :|||.:...
Mouse    73 VRPRSPT--PRVGRRLARRKPRYQRQESAQCMVQARAVALSNRKTPGRSA------RRSATAARA 129

  Fly   241 QAKVPPSNMSCPSTQ----TLKPSPPSKIVVNSFHGSSMLSTQQQEEKSRLLTQNGLTKSAATAL 301
            ..:||  .:.....|    :::.....|:       ||.||....:|:::|  :.|:.:..:::.
Mouse   130 LGRVP--GVGGQKNQLREASMENGERKKL-------SSTLSDGDHKEENKL--KQGIPQDLSSSP 183

  Fly   302 ETSLYA----------------SLYANAPQNSQPQFHSPRISGGDHVASYVGVSLN------KGA 344
            :...|.                |:|.          |.|.|........:|....|      :..
Mouse   184 KLDRYKIARQLTEKAIKERKIFSIYG----------HYPVIRATLRRKGWVEKKFNFFPKALQNL 238

  Fly   345 GHDN----DRKHEDDPCAAIDDI-----------------------------------NYYDDSD 370
            |.::    .:::::......|||                                   |:|..:.
Mouse   239 GSEDKSAETKENQEIALERFDDIHDVMSRLVKNEIPYLLWTIKRDVVDYHSLTCDQMLNHYGKTA 303

  Fly   371 SEEEYVGTPFFLEEDNTETRQSKHTRLLP---QKTPSKESVR----TTDSEASVY---FRPEAIL 425
            |....:|.             ..:.|.||   |..|:....|    .|:||...:   ||  ..:
Mouse   304 SFTTKIGL-------------CLNMRSLPWYVQANPNTFFPRCYGLCTESEKQEFLDDFR--RTV 353

  Fly   426 SPSLFPHVPPYLNFTS---------HADKGPPMPAALHRVLKWKLSPVMPKI----VKRVVLNSG 477
            :.|:...|..:.|:.|         .|....|.|         |..|..|.:    :...|:::.
Mouse   354 AASILKWVVLHQNYCSKVKGKSKKEEAKNSDPSP---------KKDPENPDLKLPSLSGQVVDTA 409

  Fly   478 FRIIKNTTDWMAVWEKHMKSPGFRTIRSHQKYNHIPGSFRI---GRKDTMWRSIYNNMKKFGKKE 539
            .::.:.....:...:..:.......: |.:::|.:...:.:   |.     .||.::...|.:.:
Mouse   410 CKVCQAYLGQLEHEDIDVSEASTEAL-SEEEWNDLTQQYYLLVHGN-----ASITDSKSYFAQCQ 468

  Fly   540 FGFMQKSYIMPD-DLESLRQVWPKNASKLTKWIVKPPASARGTGI----------RIVNKWSQFP 593
            ....:.|.:.|. :::.:|.:          ||:||.|.:||..|          .:|...||..
Mouse   469 ALLSKISSVNPQTEIDGIRNI----------WIIKPAAKSRGRDIVCMDRVENILSLVAADSQTT 523

  Fly   594 KDRPLVVQKYIERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVKYSSELSNLDERCM 658
            ||...|||||||.|:||.|.|||:|.:.::|..|||.|:.||:...||::.::|  |..||. .:
Mouse   524 KDNKWVVQKYIETPMLIYDTKFDIRQWFLVTDWNPLTIWFYKESYLRFSTQRFS--LDKLDS-AI 585

  Fly   659 HLTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESG 723
            ||.|.||.:..:|..:......|. :.||.......|:.||..     .|..:::...:....:.
Mouse   586 HLCNNSIQRRLKNDKERSPLLPCH-NMWTSTRFQEYLQKRGRG-----GTWGSIIYPSMKRAVTN 644

  Fly   724 LNRMYRQNVNFRYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPL----------------- 771
            ..|:.:.:|..|.|.|||:|.|.:|..:..|||:|||.||::|...|:
Mouse   645 AMRVAQDHVEARKNSFELYGADFILGRDFKPWLIEINSSPTMHPSTPVTAQLCAQVQEDTIKVVV 709

  Fly   772 ------------------------------DLHVKG-----------PLIQAVLNTALYQVPPKL 795
                                          ||.|:|           |:....|:.:|...|||:
Mouse   710 DRKLDRNCDIGNFELLWRQPAVELPPFNGSDLCVEGISVKKAKKQMPPIASVGLSESLLDAPPKV 774

  Fly   796  795
            Mouse   775  774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_722946.1	TTL	504..798	CDD:397308	93/364 (26%)
Ttll8	XP_006521018.1	TTL	<487..709	CDD:397308	75/240 (31%)