DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TTLL4B and ttll7

DIOPT Version :9

Sequence 1:	NP_001260010.1	Gene:	TTLL4B / 33609	FlyBaseID:	FBgn0031574	Length:	989	Species:	Drosophila melanogaster
Sequence 2:	XP_031755578.1	Gene:	ttll7 / 100038218	XenbaseID:	XB-GENE-489644	Length:	909	Species:	Xenopus tropicalis

Alignment Length:	612	Identity:	167/612 - (27%)
Similarity:	278/612 - (45%)	Gaps:	123/612 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 PHVPPYLNFTSHADKGPPMPAALHRVLKWKLSPVMPKIVKRV---------VLNSGFRIIKNTTD 486
            |.:|      :.:|.......:||..|.::.|..:.:.|::.         |:.:.:.|::..|:
Frog     2 PSLP------NESDHQATCSLSLHSDLPYQPSSSIKRKVRKKKKNGAITANVVGTKYEIVRLVTE 60

  Fly   487 WM-------------AVWE----KHMKSPGFRTIRSHQKYNHIPGSFRIGRKDTMWRSIYNNMKK 534
            .|             .:|.    :|.|   ...:|::|:.||.||...|.|||.:.|:: ..|.|
Frog    61 EMMFTKARDDDETANLIWNDCAVQHEK---IAELRNYQRINHFPGMGEICRKDCLARNM-TKMIK 121

  Fly   535 FGKKEFGFMQKSYIMPDDLESLRQVWPKNASKLTK---WIVKPPASARGTGIRIVNKWSQFPKDR 596
            ....|:.|:.:::|.|.:.... |.:.|...|..:   :|:||...|.|.||.:.....:.....
Frog   122 CQPHEYNFIPRTWIFPAEYTQF-QTYIKELKKKRRQKTFIIKPANGAMGHGISLTRNGEKLQAQD 185

  Fly   597 PLVVQKYIERPLLINDNKFDMRLYVVLTSINPLRIYMYKDGLARFASVKY--SSELSNLDERCMH 659
            .|:||:|:|:|.|:...|||:|:|:::||.:||||::|.|||.|..:.||  .|| |||.:..||
Frog   186 HLIVQEYLEKPFLLESYKFDLRIYILVTSCDPLRIFLYNDGLVRMGTEKYHPPSE-SNLSQLYMH 249

  Fly   660 LTNYSINKFSQNYAKNEDFNACQGHKWTLQSLWSCLENRGVNTKRLWATLRNLVIKGIVSGESGL 724
            |||||:||.::|:.::|..|  :|.|.:::.....|.....:..:.|..:.:||:|.::..|..:
Frog   250 LTNYSVNKHNENFERDETEN--RGSKRSIKWFTEFLRANDYDISKFWNDISDLVVKTLIVAEPHV 312

  Fly   725 NRMYR-----QNVNFRYNCFELFGFDVLLDENLVPWLLEINISPSLHSELPLDLHV-KGPLIQAV 783
            ...||     |:......|||:.|||::||..|.|||||||.:||..::..:|..| ||.|:.|:
Frog   313 LHAYRMCRPGQHPTSESVCFEVLGFDIILDRKLKPWLLEINRAPSFGTDQKIDHDVKKGVLLNAL 377

  Fly   784 LNTALYQVPPKLN-ERQQADILEELNLTG------PLCHD--KRIFTTCLTAEEVRKHNQYTNRS 839
            ....:.....|.| .:|:|:..:.|...|      |...|  |:..|.....||:::......:.
Frog   378 KLLNIRASDKKKNLAKQKAEAQKRLYGQGSMKRLSPASSDWEKQRHTLERRKEELKERLAQVRKQ 442

  Fly   840 IEFREEYVDTILDNLLPDDVRCLIVAEDELARCQPLERIFPTAGTHVYLRYVENARYYNRLLDAW 904
            |. ||||.:..|.|     .|.:...||:|.    ||                  :|...|..|:
Frog   443 IS-REEYENRHLGN-----YRRIYPPEDKLL----LE------------------KYEGLLATAF 479

  Fly   905 ETKYAKNREMGIALLSRYCRDKYHLQVSDAAMEKEPNVAL---TEIDMLHVRK-----DEVLDGA 961
            :|..|     |.|                |::::|.|..|   .|.|:|.:.:     ||.|.|.
Frog   480 QTFLA-----GRA----------------ASLQREMNNPLKRMKEEDILDLLEQCELDDEKLSGK 523

  Fly   962 TTLAILKPVVQEGCEVAPIPDACIEIK 988
            .|    :|  :|...::.:|::...:|
Frog   524 PT----RP--KEPRTLSSMPESTQTLK 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TTLL4B	NP_001260010.1	TTL	504..799	CDD:281171	106/306 (35%)
ttll7	XP_031755578.1	TTL	92..378	CDD:397308	104/290 (36%)
ttll7	XP_031755578.1	Smc	<375..>521	CDD:224117	42/194 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250453at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920