DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and Foxj2

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_068699.1	Gene:	Foxj2 / 60611	MGIID:	1926805	Length:	565	Species:	Mus musculus

Alignment Length:	351	Identity:	103/351 - (29%)
Similarity:	135/351 - (38%)	Gaps:	125/351 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 GETTDGDAENKSNDGKPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRD 219
            |..||.:|....::....:|    .||.|||..||..||..|..|::||:.||.:|..|.|||::
Mouse    45 GSPTDPNATLSKDEAAVHQD----GKPRYSYATLITYAINSSPAKKMTLSEIYRWICDNFPYYKN 105

  Fly   220 NKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRL 284
            ...||:|||||||||||||.||||..||||||:||.:| :..|:                ||.|
Mouse   106 AGIGWKNSIRHNLSLNKCFRKVPRPRDDPGKGSYWTID-TCPDI----------------SRKR- 152

  Fly   285 AAFKRSLIGPMFPGLAAYPQFGQFLTYPP------TAPSLLASMYQRYNPFAPKGG-PG------ 336
                                     .:||      .:|...||.       :|:|| ||
Mouse   153 -------------------------RHPPDDDLSQDSPEQEASK-------SPRGGVPGSGEASL 185

  Fly   337 -HPGLP----------------PG-LPG---LPGPPGPQGPPGPPPPPFVAPPTSSEL---YQRL 377
             |.|.|                || :.|   ..|.||.:...|.||    ...|:.:.   |..:
Mouse   186 SHEGTPQMSLQSPSSVANYSQGPGSVDGGAVAAGAPGQESTEGAPP----LYNTNHDFKFSYSEI 246

  Fly   378 QYQQL----------------LHQHAAAAALA---------AHQRQLSVAAASAASQPPPTHHHP 417
            .:|.|                ..||..::.|.         .:|:| .........||||....|
Mouse   247 NFQDLSWSFRNLYKSMLERSSSSQHGFSSLLGDMPPSNNYYVYQQQ-QQQQPPPQPQPPPQQPQP 310

  Fly   418 HLAVGQAPLSPGGDSPGPSPQPLHKP 443
            ...  ||| :.|..:.|.:| |||.|
Mouse   311 QQQ--QAP-TQGPSNVGGAP-PLHTP 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	49/84 (58%)
Foxj2	NP_068699.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..61		4/15 (27%)
		Forkhead	66..143	CDD:278670	47/76 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..233		39/161 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..399		17/48 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820