DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slp2 and foxh1

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_571577.1	Gene:	foxh1 / 57930	ZFINID:	ZDB-GENE-000616-15	Length:	472	Species:	Danio rerio

Alignment Length:	308	Identity:	94/308 - (30%)
Similarity:	131/308 - (42%)	Gaps:	71/308 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 ETTDGDAENKSNDGKPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDN 220
            |..||:    |:.||. |:.:...||||||.|:|.|.|:.|.||:|||:.|.:.|.|..|:::.|
Zfish    78 ELQDGN----SSGGKK-KNYQRYPKPPYSYLAMIAMVIQNSPEKKLTLSEILKEISTLFPFFKGN 137

  Fly   221 KQGWQNSIRHNLSLNKCFVKVPRHYDDP-GKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRL 284
            .:||::|:|||||...|||||.:....| ||||:|.::.:...:.:      |:|:.||.||...
Zfish   138 YKGWRDSVRHNLSSYDCFVKVLKDPGKPQGKGNFWTVEVNRIPLEL------LKRQNTAVSRQDE 196

  Fly   285 AAFKRSLIGPMFPGLAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPG 349
            ..|.:.|...:|.|                        |.:.|...|        |||. ..||.
Zfish   197 TIFAQDLAPYIFQG------------------------YSQPNKSKP--------LPPE-SSLPP 228

  Fly   350 PPGPQGPPGPPPPPFVAPPTSSELYQRLQYQQLLH--QHAAAAALAAHQRQLSVAAASAASQPPP 412
            .|..|.|| |...|:     ..:|........|||  :.|::|.....:|:      |....|||
Zfish   229 VPTRQSPP-PSEDPY-----RPKLDSTFAIDSLLHSLRPASSAGEGLRERE------SWGVGPPP 281

  Fly   413 THHHPHLAVGQAP--LSPGGDSPGPSPQPLH-------KPVTVVSRNS 451
               |........|  .|..|.|...|..|..       :.||||.:.|
Zfish   282 ---HTRSTTPPRPCNASYNGSSSASSVSPASDFSDEDWRGVTVVGKRS 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	40/85 (47%)
foxh1	NP_571577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..56
		FH	97..174	CDD:238016	40/76 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..246		14/49 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..360		19/75 (25%)
		SMAD-interaction domain (SID)	339..465
		Fast/FoxH1 motif 1 (FM1)	357..361
		Fast/FoxH1 motif 2 (FM2)	367..373
		SMAD interaction motif (SIM)	428..448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820