DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and foxh1

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001017084.1	Gene:	foxh1 / 549838	XenbaseID:	XB-GENE-1194372	Length:	515	Species:	Xenopus tropicalis

Alignment Length:	202	Identity:	63/202 - (31%)
Similarity:	90/202 - (44%)	Gaps:	45/202 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DGETTDGDAENKSNDGKPV---KDKKGN----EKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIM 211
            :|..|..:....|..|...   |.||.|    .||||||.|:|.:.|:.|.||||.|:.|.:.:.
Frog    77 EGSCTQAEGTKDSLGGDETLSRKSKKKNYHRYAKPPYSYLAMIALVIQNSPEKRLKLSQILKEVS 141

  Fly   212 TNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPG----KGNYWMLDPSAEDVFIGGSTGKL 272
            |..|:::.:..||::|||||||.|.||.||.:   |||    |||:|.:|.|...:      ..:
Frog   142 TLFPFFKGDYMGWKDSIRHNLSSNDCFKKVLK---DPGKPQAKGNFWTVDVSRIPL------DAM 197

  Fly   273 RRRTTAASRSRLAAFKRSLIGPMFPGLAAYPQFGQFLTYPPTAPSLLASMYQRYN--PFAPKGGP 335
            :.:.||.:|.....|.:.|                       ||.:|.:....:|  .:||...|
Frog   198 KLQNTALTRGGSDYFVQDL-----------------------APYILHNYKYEHNVVVYAPHHMP 239

  Fly   336 GHPGLPP 342
            .|....|
Frog   240 SHASSLP 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	41/88 (47%)
foxh1	NP_001017084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..103		6/25 (24%)
		FH	110..188	CDD:238016	39/80 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..399
		SMAD-interaction domain (SID)	377..503
		Fast/FoxH1 motif 1 (FM1). /evidence=ECO:0000255	402..406
		Fast/FoxH1 motif 2 (FM2). /evidence=ECO:0000255	412..418
		SMAD-interaction motif (SIM)	467..488
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920