DRSC/TRiP Functional Genomics Resources

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Protein Alignment slp2 and FOXB2

DIOPT Version :9

Sequence 1:NP_476834.1 Gene:slp2 / 33608 FlyBaseID:FBgn0004567 Length:451 Species:Drosophila melanogaster
Sequence 2:NP_001013757.1 Gene:FOXB2 / 442425 HGNCID:23315 Length:432 Species:Homo sapiens


Alignment Length:266 Identity:98/266 - (36%)
Similarity:127/266 - (47%) Gaps:45/266 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 KPVKDKKGNEKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSL 234
            :|.|....::||||||.:|..|||:.|:||.|.|:.||::||...||||::.|.||||:|||||.
Human     3 RPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNLSF 67

  Fly   235 NKCFVKVPRHYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRR--TTAASRSRLAAFKRSLIGPMFP 297
            |.||:|:||..|.||||::|.|.|...|:|..||..:.|:|  ...|..:.|.|..........|
Human    68 NDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHTHLHAGSTKSAPGAGP 132

  Fly   298 GLAAYPQFGQFLTYPPTAPSLLASMYQRYNPFAPKGGPGHPGLPPGLPGLPGPPGP--------- 353
            |...:|....   :|        ..:..::..|......||..||     |.||.|         
Human   133 GGHLHPHHHH---HP--------HHHHHHHAAAHHHHHHHPPQPP-----PPPPPPPPHMVHYFH 181

  Fly   354 -QGPPGPPPPPFVAPPTSSELYQRLQYQQLLH----QHAAAAALAAHQRQLSVAAASAA------ 407
             |.|..|.|||.:......:..|:.|.||..|    |.|||.|.||      .|||:||      
Human   182 QQPPTAPQPPPHLPSQPPQQPPQQSQPQQPSHPGKMQEAAAVAAAA------AAAAAAAVGSVGR 240

  Fly   408 -SQPPP 412
             ||.||
Human   241 LSQFPP 246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slp2NP_476834.1 Forkhead 180..265 CDD:306709 48/84 (57%)
FOXB2NP_001013757.1 FH 13..101 CDD:214627 49/87 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..220 27/117 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..432
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2114
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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