DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and FOXI3

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001129121.1	Gene:	FOXI3 / 344167	HGNCID:	35123	Length:	420	Species:	Homo sapiens

Alignment Length:	296	Identity:	101/296 - (34%)
Similarity:	142/296 - (47%)	Gaps:	71/296 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 KPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRH 244
            :|||||:|||.|||:.:.|::|||:.||:::..:.|:|:.:|.|||||||||||||.||.||||.
Human   145 RPPYSYSALIAMAIQSAPERKLTLSHIYQFVADSFPFYQRSKAGWQNSIRHNLSLNDCFKKVPRD 209

  Fly   245 YDDPGKGNYWMLDPSAEDVFIGGS-TGKLRRRTTAASRSRLAA----FKRSLIGPMFPGLAAYPQ 304
            .|||||||||.|||:.|.:|..|: ..|.:||:.|::.|.:||    .:..|...:..|:...|:
Human   210 EDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRSEASNGSTVAAGTSKSEEGLSSGLGSGVGGKPE 274

  Fly   305 FGQFLTYPPTAPSLLASMYQRYNPFAPKG------GPGHPGL--PPGL----------------- 344
                    ..:||.|  :...::|..|:|      .||.|.|  .|.|
Human   275 --------EESPSTL--LRPSHSPEPPEGTKSTASSPGGPMLTSTPCLNTFFSSLSSLSVSSSVS 329

  Fly   345 --PGLPGPP--GPQGPPGPPPPPFVAPPTSSELYQRLQYQQLLHQHAAAAALAAHQRQLSVAAAS 405
              ..|||..  |.||...|....| :|.:.||              |:|..|     |||.:.::
Human   330 TQRALPGSRHLGIQGAQLPSSGVF-SPTSISE--------------ASADTL-----QLSNSTSN 374

  Fly   406 AASQPPPTHHHPHLAVGQAPLSPGGDSPGPSPQPLH 441
            :..| ..:::.|.      |.|..|....|...|.|
Human   375 STGQ-RSSYYSPF------PASTSGGQSSPFSSPFH 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	52/84 (62%)
FOXI3	NP_001129121.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..122
		Forkhead	145..231	CDD:278670	53/85 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..306		19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820