DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and foxa3

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_571374.1	Gene:	foxa3 / 30559	ZFINID:	ZDB-GENE-980526-423	Length:	441	Species:	Danio rerio

Alignment Length:	444	Identity:	119/444 - (26%)
Similarity:	170/444 - (38%)	Gaps:	129/444 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PSSEISAHSLHFQHHHHPLPPTTHHSALQSPHP-VGLNLTNLMKMARTPHLKSSFSINSILPETV 72
            ||:..|..||   :.:..|......|::...:| .|||.:.|..|...|:..|...:.|.|
Zfish    29 PSAMNSVSSL---NSYINLNSACSTSSMNMGYPSAGLNSSPLSSMGGGPNHMSLSPVGSSL---- 86

  Fly    73 EHHDEDEEEDVEKKSPAKFPPNHNNNNLNTTNWGS------PEDH-EAESDPESDLDVTSMSPAP 130
                                     |..:.|..||      |..| ::...|.|.:..    |:|
Zfish    87 -------------------------NPSSLTQLGSSASTLGPLSHYQSMGQPMSQISY----PSP 122

  Fly   131 VA-NPNESDPDEVDEEFVEEDIECDGETTDGDAENKSNDGKPVKDKKGNEKPPYSYNALIMMAIR 194
            .: |..:..|                              ||.:....:.||||||.:||.|||:
Zfish   123 TSLNRTKEMP------------------------------KPYRRSLTHAKPPYSYISLITMAIQ 157

  Fly   195 QSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPS 259
            ||..|.||||.||::||...||||:|:|.|||||||:||.|.|||||.|..|.||||:||.|.|:
Zfish   158 QSQSKMLTLNEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPN 222

  Fly   260 AEDVFIGGSTGKLRRRTTAASRSRLAAFKRSLIGPMFPGLAAYPQFGQFLTYPPTAPSLLASMYQ 324
            :.::|..|...:.::|.....::...:..:|..|....|  .:...|....:.||..|..|.
Zfish   223 SGNMFENGCYLRRQKRFKIEEKAGKKSSSKSQDGSSTKG--THSSEGMQEEHSPTTGSDGAE--- 282

  Fly   325 RYNPFAPKGGPGHPGLPPGLPGLPGPPGPQGPPGPPPPPFVAPPTSSELYQRLQYQQLLHQHAAA 389
                 :......|.|                             ::||..||...|  |...:.|
Zfish   283 -----SAHSDSSHAG-----------------------------STSEEQQRSLVQ--LDCPSQA 311

  Fly   390 AALAAHQRQLSVAAASAASQPPPTHH-HPHLAVGQAPLSPG-GDSPGPSPQPLH 441
            ..| .|...:.:.::.:||.||.:.| |          |.| |:||.....|:|
Zfish   312 PNL-LHSSPVPIPSSVSASMPPSSSHLH----------SQGMGNSPHLLGSPMH 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	53/84 (63%)
foxa3	NP_571374.1	Forkhead_N	17..142	CDD:254796	31/178 (17%)
		FH	143..231	CDD:214627	54/87 (62%)
		HNF_C	374..>408	CDD:286443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910