DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slp2 and foxa1

DIOPT Version :9

Sequence 1:	NP_476834.1	Gene:	slp2 / 33608	FlyBaseID:	FBgn0004567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_571359.2	Gene:	foxa1 / 30541	ZFINID:	ZDB-GENE-990415-78	Length:	427	Species:	Danio rerio

Alignment Length:	307	Identity:	94/307 - (30%)
Similarity:	140/307 - (45%)	Gaps:	71/307 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EGLPSSEISAHSLHFQHHHHPLPPTTHHSALQSPHPVGLNLTNLMKMARTPHL-KSSFSIN---- 65
            ||..:.:.|::....|..:.|:..::.:..|.|.:    |:.:.|.|:.:.:: .|||:::
Zfish     8 EGHETPDWSSYYNDAQEVYSPMTNSSMNPGLSSMN----NMNSYMGMSTSGNMTSSSFNMSYANP 68

  Fly    66 ----SILPETVEHHDEDEEEDVEKKSPAKFPPNHNNNNL--NTTNWG---SPEDHEAESDPESDL 121
                .:.|.|:                |..|.....|.:  ..::.|   ||.:..|.:...|.:
Zfish    69 ALGAGLSPGTM----------------AGMPTGGAMNGMGGGVSSMGTALSPSNLNAMTAQHSSM 117

  Fly   122 DV----TSMSPA----PVANPNESDPDEVDEEFVEEDIECDGETTDGDAENKSNDGKPVKDKKGN 178
            :.    |||||.    ..|.||                           .|::.|.|..:....:
Zfish   118 NALNPYTSMSPTMSSMTYAQPN---------------------------LNRARDNKTFRRSYPH 155

  Fly   179 EKPPYSYNALIMMAIRQSSEKRLTLNGIYEYIMTNHPYYRDNKQGWQNSIRHNLSLNKCFVKVPR 243
            .||||||.:||.|||:|:..|.|||:.||::||...||||.|:|.|||||||:||.|.|||||.|
Zfish   156 AKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVSR 220

  Fly   244 HYDDPGKGNYWMLDPSAEDVFIGGSTGKLRRRTTAASRSRLAAFKRS 290
            ..|.||||:||.|.|.:.::|..|.  .|||:.......:|...|||
Zfish   221 SPDKPGKGSYWTLHPDSGNMFENGC--YLRRQKRFKCDKKLPDGKRS 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slp2	NP_476834.1	Forkhead	180..265	CDD:306709	51/84 (61%)
foxa1	NP_571359.2	Forkhead_N	17..156	CDD:254796	31/185 (17%)
		FH	157..245	CDD:214627	52/87 (60%)
		HNF_C	357..416	CDD:286443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910